Kaposi's sarcoma complicating corticosteroid therapy for temporal arteritis

Leung, Frances; Fam, Adel G.; Osoba, David

doi:10.1016/0002-9343(81)90135-2

Cited by 72 publications

(13 citation statements)

References 11 publications

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“…The immunosuppressive effects of corticosteroid medications could induce KSHV reactivation and dissemination of the virus or the malignant cells. For example, glucocorticoids have been shown to enhance KS cell growth, possibly by blocking TGF-β[Cai, Zheng, Lotz, Zhang, Masood, and Gill, 1997], and remission of KS has been reported with reductions in corticosteroid medication usage[Kroumpouzos, Delaney, and Phillips, 2000;Leung, Fam, and Osoba, 1981]. Together these studies support a role of corticosteroids in the development of cKS.…”

Section: Discussionmentioning

confidence: 94%

Risk Factors for Classical Kaposi Sarcoma in a Population-based Case-control Study in Sicily

Anderson

Lauria

Romano

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Classical Kaposi sarcoma is a rare complication of Kaposi sarcoma-associated herpes virus (KSHV) infection. We conducted a population-based, frequency-matched case-control study in Sicily to further investigate the reported inverse relationship between smoking and classical Kaposi sarcoma and to identify other factors associated with altered risk. Methods: All incident, histologically confirmed classical Kaposi sarcoma cases in Sicily were eligible. A two-stage cluster sample design was applied to select population controls. KSHV seropositivity was determined using four antibody assays (K8.1 and orf73 enzyme immunoassays and two immunofluorenscence assays). Using SAS-callable SUDAAN, we compared the characteristics of classical Kaposi sarcoma cases and KSHV-seropositive controls. Odds ratios (OR) and 95% confidence intervals (CI) are presented. Results: In total, 142 classical Kaposi sarcoma cases and 123 KSHV-seropositive controls were recruited. Current cigarette smoking was associated with reduced risk of

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Section: Discussionmentioning

confidence: 94%

Risk Factors for Classical Kaposi Sarcoma in a Population-based Case-control Study in Sicily

Anderson

Lauria

Romano

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Little et al (1983) controlled Kaposi's lesions without rejection in a renal transplant recipient after reducing cyclosporine to 100 mg per day. Kaposi 's sarcoma has been noted under other conditions of immunosuppression, for example, as a complication of corticosteroid therapy in temporal arteries (Leung et al, 1981).…”

Section: Relationship Of Human CMV To Cancermentioning

confidence: 99%

Cytomegalovirus

1991

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All rights reserved 90-14345 CIP No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher Preface to the First EditionAlthough there are a number of excellent current reviews on one or another aspect of cytomegalovirus, the last comprehensive treatment of this subject was that of Krech et al. (197la). In view of the amazing advances in the virological, epidemiologic, and clinical knowledge of cytomegaloviruses, an up-to-date book is needed. Such a work should cover many areas of expertise and a voluminous technical literature. Each area might have been reviewed and analyzed by workers more expert than myself. However, I have embarked on the entire venture alone in order to attain unity and continuity in this book, characteristics that are not easily achieved in the more popular multiauthored works. I have tried to review the Iiterature and provide a critical summary for each area discussed. To do this, I provide as much of the primary data of the relevant works as needed and not just the qualitative conclusions. Inevitably, the flow of the narrative may be interrupted by dry facts and figures. However, such information is essential to make this a meaningful reference work. But for those not interested in such details, I have provided at what I hope are crucial points critiques and summaries.This book is not an exhaustive review of all the literature. This is probably no Ionger possible or even desirable. By selection, however, one runs the risk of having missed or ignored important papers. I am keenly aware of this, and I wish to apologize for such oversight, if that is possible.I visualize this work as being useful for physicians, scientists, and students interested in the biology of and infection by human cytomegalovirus. I feel that to understand these, the basic virology of this virus and related herpesviruses must be included. Topics that have not advanced a great deal and that are adequately described in available works, such as the anatomic pathology, have not been reviewed in detail. The emphasis has been placed on newer insights in the virology, immunology, serology, epidemiology, and especially clinical aspects of human cytomegalovirus. I wish tobring out the interactions of knowledge in these areas. Part II is a much shorter treatment of the nonhuman cytomegaloviruses, reviewed primarily from the point of view of their contribution to the understanding of the human virus. V vi Preface to the First Edition Finally, I wish to thank Drs. Charles R. Rinaldo, Jr., John A. Armstrong, and Donald N. Medearis for their critical review of the manuscript. Their suggestions were invaluable. Dr. John N. Dowling's thorough review of CMV infection in patients with malignancies was the basis of Section 13.4. I also acknowledge the indispensable and patient secretarial assistance of Ms.The remarkable medical events and advances in knowle...

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“…3) Kaposi's sarcoma in individuals receiving immunosuppressive drug therapy is now well-documented (26,28,42,53). In organ transplant recipients, Kaposi's sarcoma compromises 3% of all de novo neoplasms.…”

Section: Clinical Categoriesmentioning

confidence: 99%

Neurological complications of Kaposi's sarcomat

et al. 1983

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We analyzed the neurological complications in 25 patients with Kaposi's sarcoma, 5 encountered at Memorial Sloan-Kettering Cancer Center and 20 culled from the literature. Patients with all clinical forms of Kaposi's sarcoma [14 classical cases, 2 African cases, 5 cases associated with immunosuppressive therapy and 4 cases associated with acquired immunodeficiency syndrome (AIDS)] suffered neurological dysfunction which included neoplastic involvement of the nervous system (Kaposi's sarcoma or another primary), autoimmune disorders and opportunistic infections. Neoplastic involvement was recorded most frequently in patients with classical and African Kaposi's sarcoma and was favored in a setting of extensive tumor dissemination. Opportunistic infections (cryptococcal meningitis and cerebral toxoplasmosis) were observed in all forms of Kaposi's sarcoma but were most frequent in AIDS cases and correlated with the degree of immune dysfunction. Our data suggest that more diverse opportunistic central nervous system infections, neurological disorders of an autoimmune nature, and neoplastic involvement of the nervous system are to be anticipated in AIDS.

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Kaposi's sarcoma complicating corticosteroid therapy for temporal arteritis

Cited by 72 publications

References 11 publications

Risk Factors for Classical Kaposi Sarcoma in a Population-based Case-control Study in Sicily

Risk Factors for Classical Kaposi Sarcoma in a Population-based Case-control Study in Sicily

Cytomegalovirus

Neurological complications of Kaposi's sarcomat

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