Kaposi’s sarcoma-associated herpesvirus seropositivity is associated with type 2 diabetes mellitus: A case–control study in Xinjiang, China

Cui, Meng; Fang, Qiwen; Zheng, Jun; Shu, Zhanjun; Yin, Chen; Fan, Yage; Zhao, Jin; Wood, Charles; Zhang, Tiejun; Zeng, Yan

doi:10.1016/j.ijid.2019.01.003

Cited by 9 publications

(9 citation statements)

References 31 publications

(41 reference statements)

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“…The KSHV pathway contains genes related to IFN antiviral response, inflammatory cytokines, and cell proliferation pathways [ ]. Interestingly, the association between KSHV and DM was previously reported by observational studies ( 107 , 108 ). Cui et al described that patients with T2DM had an elevated risk of KSHV ( 107 ).…”

Section: Discussionsupporting

confidence: 51%

“…Interestingly, the association between KSHV and DM was previously reported by observational studies (107,108). Cui et al described that patients with T2DM had an elevated risk of KSHV (107). Accordingly, Piras et al showed 58% of T2DM patients were seropositive for KSHV vs. 27% of the healthy subjects (108).…”

Section: Discussionmentioning

confidence: 86%

“…html]. Interestingly, the association between KSHV and DM was previously reported by observational studies (107,108). Cui et al described that patients with T2DM had an elevated risk of KSHV (107).…”

Section: Discussionmentioning

confidence: 87%

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The Impact of lncRNAs in Diabetes Mellitus: A Systematic Review and In Silico Analyses

et al. 2021

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Long non-coding RNAs (lncRNAs) are non-coding transcripts that have emerged as one of the largest and diverse RNA families that regulate gene expression. Accumulating evidence has suggested a number of lncRNAs are involved in diabetes mellitus (DM) pathogenesis. However, results about lncRNA expressions in DM patients are still inconclusive. Thus, we performed a systematic review of the literature on the subject followed by bioinformatics analyses to better understand which lncRNAs are dysregulated in DM and in which pathways they act. Pubmed, Embase, and Gene Expression Omnibus (GEO) repositories were searched to identify studies that investigated lncRNA expression in cases with DM and non-diabetic controls. LncRNAs consistently dysregulated in DM patients were submitted to bioinformatics analysis to retrieve their target genes and identify potentially affected signaling pathways under their regulation. Fifty-three eligible articles were included in this review after the application of the inclusion and exclusion criteria. Six hundred and thirty-eight lncRNAs were differentially expressed between cases and controls in at least one study. Among them, six lncRNAs were consistently dysregulated in patients with DM (Anril, Hotair, Malat1, Miat, Kcnq1ot1, and Meg3) compared to controls. Moreover, these six lncRNAs participate in several metabolism-related pathways, evidencing their importance in DM. This systematic review suggests six lncRNAs are dysregulated in DM, constituting potential biomarkers of this disease.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 86%

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The Impact of lncRNAs in Diabetes Mellitus: A Systematic Review and In Silico Analyses

et al. 2021

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Section: Effects Of T2dm On the Susceptibility Of Patients To Infectimentioning

confidence: 99%

“…Cui et al have recently reported that T2DM patients have an increased risk of infection with Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) ( 241 ). They further showed that the viral load and antibody titers are positively correlated with blood glucose levels ( 241 ). Diabetic patients also have been shown to have an increased risk of infection with the severe acute respiratory syndrome coronavirus (SARS-CoV) ( 242 ), Middle East respiratory syndrome coronavirus (MERS-CoV) ( 243 ), SARS coronavirus 2 (SARS-CoV-2) ( 21 , 22 ), hepatitis C virus (HCV) ( 244 – 246 ), and West Nile virus encephalitis (WNVE) ( 247 ).…”

Section: Effects Of T2dm On the Susceptibility Of Patients To Infectimentioning

confidence: 99%

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

et al. 2020

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Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM). The field of immunometabolism implies a bidirectional link between the immune system and metabolism, in which inflammation plays an essential role in the promotion of metabolic abnormalities (e.g., obesity and T2DM), and metabolic factors, in turn, regulate immune cell functions. Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM. Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. Hyperglycemia and the subsequent inflammation are the main causes of micro-and macroangiopathies in the circulatory system. They also promote the gut microbiota dysbiosis, increased intestinal permeability, and fatty liver disease. The impaired immune system together with metabolic imbalance also increases the susceptibility of patients to several pathogenic agents such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, the need for a proper immunization protocol among such patients is granted. The focus of the current review is to explore metabolic and immunological abnormalities affecting several organs of T2DM patients and explain the mechanisms, whereby diabetic patients become more susceptible to infectious diseases.

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Association between human herpesvirus 8 and lipid profile in northwest China: A cross‐sectional study

Zhang,

Wang,

et al. 2024

Journal of Medical Virology

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Human herpesvirus 8 (HHV‐8) infection shows obvious regional and ethnic differences. Although studies have shown that these differences may be associated with lipid metabolism, to date, no large‐scale studies have explored this. This study explored the seropositivity rate of HHV‐8 among 2516 residents from 10 regions of northwest China and then the correlates of HHV‐8 infection with lipid profile. The HHV‐8 serological positivity rate was 15.6% among all residents. The HHV‐8 seroprevalence ranged 11.2–27.6% among different ethnicities. Across different BMI levels, the positive rates of HHV‐8 were 27.6%, 16.9%, and 13.6% for a BMI < 18.5, 18.5–24.9, and ≥25, respectively. HHV‐8 seropositivity rate was lower for hypertensive people (12.6%) than for non‐hypertensive people (16.7%). Univariate logistic regression analyses revealed that age, hypertension, systolic blood pressure, BMI, total cholesterol, and high‐density lipoprotein cholesterol (HDL‐C) significantly correlated with HHV‐8 seropositivity (p < 0.05). Multivariate logistic regression analysis after adjusting for confounding factors showed that HDL‐C (odds ratio [OR]: 0.132, 95% confidence interval [CI], 0.082–0.212; p < 0.001) and BMI (OR: 0.959, 95% CI 0.933–0.986; p = 0.003) were associated with HHV‐8 seropositivity. Subgroup analyses concerning ethnicity, sex, or age demonstrated a consistent relationship with HDL‐C. The results of HHV‐8 seropositivity and BMI were inconsistent in the subgroups. However, Spearman's correlation analysis between HHV‐8 serum antibody titer and HDL‐C levels showed no linear relationship among HHV‐8 seropositive individuals (ρ = −0.080, p = 0.058). HHV‐8 serum antibody titers were also not significantly correlated with BMI (ρ = −0.015, p = 0.381). Low HDL‐C levels may be an independent risk factor for HHV‐8 infection, but there is no significant correlation between HDL‐C levels and HHV‐8 antibody titers.

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Kaposi’s sarcoma-associated herpesvirus seropositivity is associated with type 2 diabetes mellitus: A case–control study in Xinjiang, China

Cited by 9 publications

References 31 publications

The Impact of lncRNAs in Diabetes Mellitus: A Systematic Review and In Silico Analyses

The Impact of lncRNAs in Diabetes Mellitus: A Systematic Review and In Silico Analyses

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Association between human herpesvirus 8 and lipid profile in northwest China: A cross‐sectional study

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