Kaposi's sarcoma–associated herpesvirus/human herpesvirus 8 infection in reactive lymphoid tissues: a model for KSHV/HHV-8–related lymphomas?

Lazzi, Stefano; Bellan, Cristiana; Amato, Teresa; Palummo, Nazzareno; Cardone, Concetta; D’Amuri, Alessandro; Luca, Fabio De; Beyanga, Medard; Facchetti, Fabio; Tosi, Piero; Leoncini, Lorenzo

doi:10.1016/j.humpath.2005.08.020

Cited by 19 publications

(30 citation statements)

References 34 publications

(34 reference statements)

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“…The observation of a high association of HHV-8 with LPP might be explained by geographic regions of high seroprevalence of HHV-8, such as Italy or East Africa. 10 However, all included subjects in the present study were of German descent and living in Germany, where the HHV-8 prevalence is considered to be low (Ͻ5%). 12 Moreover, although not documented in the patient's files, high-risk sexual behavior and preferences that could explain the high association of HHV-8 seem to be rather unlikely in the investigated cohort.…”

Section: Commentmentioning

confidence: 98%

“…Human herpesvirus type 8 carries at least 11 ORFs that encode homologues to cellular proteins involved in signal transduction, cell cycle regulation, inhibition of apoptosis, and immune modulation. 10 Thus, HHV-8 has the genetic armamentarium of an oncogenic virus. A sexual mode of transmission has been confirmed for HHV-8, although an obvious nonsexual horizontal mode of transmission exists in endemic regions.…”

Section: Commentmentioning

confidence: 99%

See 1 more Smart Citation

High Association of Human Herpesvirus 8 in Large-Plaque Parapsoriasis and Mycosis Fungoides

Kreuter

Bischoff²,

Skrygan³

et al. 2008

Arch Dermatol

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Section: Commentmentioning

confidence: 98%

Section: Commentmentioning

confidence: 99%

High Association of Human Herpesvirus 8 in Large-Plaque Parapsoriasis and Mycosis Fungoides

Kreuter

Bischoff²,

Skrygan³

et al. 2008

Arch Dermatol

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“…The exact oncogenic mechanism of KSHV infection in the pathogenesis of these lymphoproliferative disorders is partially clear [25][26][27]. Unlike other viruses, HHV-8 encodes several human homologues genes including cytokines (IL-6, MIPs, IRFs) and regulatory proteins (cyclin D) [26].…”

Section: Discussionmentioning

confidence: 99%

“…Unlike other viruses, HHV-8 encodes several human homologues genes including cytokines (IL-6, MIPs, IRFs) and regulatory proteins (cyclin D) [26]. These proteins may play significant roles in the pathogenesis of HHV-8-associated diseases.…”

Section: Discussionmentioning

confidence: 99%

Lymph node-based disease and HHV-8/KSHV infection in HIV seronegative patients: report of three new cases of a heterogeneous group of diseases

D’Antonio

Addesso²,

Memoli

et al. 2011

Int J Hematol

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We describe three cases of lymph proliferative diseases characterized by the presence of lymphoma cells expressing the KSHV/HHV-8 antigen with or without EBV expression. The patients were HIV seronegative without serous effusions. One case was diagnosed as KSHV-germinotropic lymphoproliferative disorder due to the presence of atypical plasmablasts involving germinal centers. These plasmablasts were positive for MUM1 and vIL6, co-expressed EBV and LNA-1 of HHV-8/KSHV, and showed a polyclonal pattern of Ig gene rearrangements on PCR. The disease was localized and the prognosis was good. In two other cases, a diagnosis of KSHV/HHV-8-related diffuse large cell B-lymphoma morphology was made. The lymphoma cells were anaplastic or frankly pleomorphic, expressed KSHV but not EBV, and were positive for CD20, MUM1, PAX-5, and vIL6. In both cases the prognosis was poor. On the basis of the features observed, we raise three considerations: (1) KSHV-related lymphoproliferative disorders represent a distinctive and heterogeneous group of diseases with variable clinico-pathologic findings and immunophenotypes (BCL6-/MUM1+/CD138- and BCL6+/MUM1+/CD138- or BCL6-/MUM1+/CD138+). (2) Although the pathogenic mechanism of HHV8 in lymphomagenesis is unclear, the presence the viral DNA in lymph nodes of HIV- patients is not a simply opportunistic infection, but is directly implicated in the pathogenesis of KSHV-related diseases; the activation of IL-6 receptor signalling may play an important role in most cases. (3) The different prognoses among different diseases with KSHV etiology may be related to the fact that the pathogenic potential appears to be constrained by a competent immune system.

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“…First, during primary infection, the host develops innate responses based on natural antibodies, the complement system, and innate cytotoxic cells. Second, neutralizing antibodies are produced, and during latency, the virus yields different proteins that escape the cytotoxic response and enable its persistence in a relatively silent mode [44]. In a third step, the virus is present in infected cells (peripheral blood mononuclear cells/blood reservoir) and in tumors.…”

Section: Immune Responsementioning

confidence: 99%

Human herpesvirus 8 infections in patients with immunodeficiencies

2008

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Kaposi's sarcoma–associated herpesvirus/human herpesvirus 8 infection in reactive lymphoid tissues: a model for KSHV/HHV-8–related lymphomas?

Cited by 19 publications

References 34 publications

High Association of Human Herpesvirus 8 in Large-Plaque Parapsoriasis and Mycosis Fungoides

High Association of Human Herpesvirus 8 in Large-Plaque Parapsoriasis and Mycosis Fungoides

Lymph node-based disease and HHV-8/KSHV infection in HIV seronegative patients: report of three new cases of a heterogeneous group of diseases

Human herpesvirus 8 infections in patients with immunodeficiencies

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