Kaposi’s sarcoma after liver transplantation

Benedetto, Fabrizio Di; Sandro, Stefano Di; Ruvo, N. De; Berretta, Massimiliano; Masetti, Michele; Montalti, Roberto; Ballarin, Roberto; Cocchi, Stefania; Potenza, Leonardo; Luppi, Mario; Gerunda, G.E.

doi:10.1007/s00432-007-0329-3

Cited by 40 publications

(36 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Distinct from most other European studies [16], [17], [18] with the exception of the series of Collett and Al. (19), the follow-up of our patients is quite long, as our first liver transplant was performed in 1983, allowing a broader perspective on this problem.…”

Section: Discussionmentioning

confidence: 69%

“…In immunocompetent subjects, cervical cancer has been linked to Human Papilloma Virus infections, and Kaposi's sarcoma with Human Herpes Virus 8. Infection with Epstein Barr Virus is the main risk factor for developing lymphoproliferative disorders [12], [13], [18], nasopharyngeal cancer and some types of leiomyosarcoma. HCV has a controversial role [12].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

et al. 2013

View full text Add to dashboard Cite

BackgroundDe novo tumors (DNT) after liver transplantation (LT) represent a growing concern.Patients and MethodsWe analyzed the incidence of DNT, type, time of onset, risk factors and mortality (as of 2010) in 494 adult patients transplanted in the last 26 years (1983–2009).ResultsDNT occurred in 41 (8.3%) of the patients. The Standardized Incidence Ratio (SIR) compared with the Italian population was 1.8. There was a higher incidence in males (SIR 2.0), an expected extremely high rate of Kaposi’s sarcoma (SIR 127.95) and unexpected higher rates of tumors of the bladder in males (SIR 3.3). The incidence of DNT was higher within the first two years of LT (SIR 2.7) for Kaposi’s sarcoma (SIR 393.3) and after 10 years (SIR 1.7) for bladder tumors (SIR 10.6). Multivariate analysis identified alcoholic cirrhosis (HR = 3.0, 95% CI = 1.2–7.8) and sclerosing cholangitis (HR = 3.5, 95% CI = 1.1–11.3) in the recipient as main risk factors for the occurrence of DNT.ConclusionsSurveillance protocols for DNT must be specifically oriented to patients transplanted for alcoholic cirrhosis and sclerosing cholangitis. They should focus on early detection of Kaposi’s sarcomas, and more remarkably, on late development bladder tumors in men after LT.

show abstract

Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Kaposi’s sarcoma, thought to be driven at least in part by HHV8 proliferation related to the immunosuppression that accompanies transplantation, was recently reported to occur at a rate of approximately 2% after LT [13], similar to that in the HIV-TR report. All de novo KS lesions in the HIV-TR study were cutaneous, and all were treated successfully with the addition of rapamycin to the immunosuppressive regimen.…”

Section: Neoplasia After Transplantation In the Hiv Patientmentioning

confidence: 84%

Malignancy in the HIV-infected patients undergoing liver and kidney transplantation

Nissen

Barin

Stock

2012

Current Opinion in Oncology

View full text Add to dashboard Cite

Purpose of review The transplant community has seen gradual acceptance of liver and kidney transplantation (LT, KT) in carefully selected HIV positive patients. The addition of transplant immunosuppressants to an already immunocompromised state, however, may increase the risk of malignancy. Recent findings KT and LT have been successful in large series of carefully selected HIV infected patients, with graft and patient survival approaching those of non-HIV infected patients. The incidence of acute cellular rejection (KT) and of recurrent hepatitis C (LT) remains challenging. Hepatocellular carcinoma, which is a common indication for LT, seems to occur at a younger age and to have a generally worse outcome in the HIV+ patient. LT outcomes for HCC in these patients, however, do not seem to be compromised. Rates of Kaposi’s sarcoma (KS) and other de novo malignancies such as skin cancer are relatively low after transplant. KS may regress with use of the mTOR inhibitor sirolimus. In HIV+ patients followed closely for HPV-related anal neoplasia after transplantation there may be an increased risk of progression to high grade squamous intraepithelial lesions. Summary The risk of recurrent or de novo malignancy after solid organ transplantation in HIV patients is low. HPV-related neoplasia, however, requires further study.

show abstract

“…4 Algunos informes de SK en trasplante hepático describen buena evolución con quimioterapia, con antivirales 14 o con conversión del tratamiento inmunosupresor a sirolimus. 6 En receptores adultos de trasplante renal, el sirolimus inhibió la progresión de SK y mantuvo, además, una inmunosupresión adecuada.…”

Section: Discussionunclassified

Sarcoma de Kaposi por virus del herpes humano de tipo 8 en un receptor de trasplante hepático pediátrico. Caso clínico

Malla¹,

Perez²,

Cheang³

et al. 2013

Arch Argent Pediat

View full text Add to dashboard Cite

Arch Argent Pediatr 2013;111(5):e125-e128 / e125Presentación de casos clínicos RESUMEN Los pacientes que reciben tratamiento inmunosupresor están en riesgo de desarrollar tumores malignos. La infección primaria o reactivación del virus del herpes humano de tipo 8 (HHV-8) puede predisponer al sarcoma de Kaposi después del trasplante de un órgano sólido. En los receptores de trasplantes pediátricos, este sarcoma tiene baja incidencia y mal pronóstico. Se informa la presentación clínica de un sarcoma de Kaposi en un ganglio linfático luego de una infección por HHV-8 en un niño a los 4 meses del trasplante hepático. El paciente tuvo buena evolución con suspensión del tacrolimus y conversión a sirolimus un mes después del diagnóstico. En nuestro conocimiento, este es el primer caso de sarcoma de Kaposi en un receptor pediátrico de trasplante hepático informado en nuestro país y creemos que esta entidad debería considerarse como diagnóstico diferencial en las complicaciones postrasplante. Palabras clave: trasplante hepático, pediatría, virus del herpes humano de tipo 8, malignidad, sarcoma de Kaposi.

show abstract

Kaposi’s sarcoma after liver transplantation

Abstract: KS should be treated by a multidisciplinary approach to obtain an early diagnosis and best management. Effective treatment with immunosuppression reduction or switch to sirolimus is mandatory and can induce complete regression.

Cited by 40 publications

References 24 publications

Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

Malignancy in the HIV-infected patients undergoing liver and kidney transplantation

Sarcoma de Kaposi por virus del herpes humano de tipo 8 en un receptor de trasplante hepático pediátrico. Caso clínico

Contact Info

Product

Resources

About