We have determined the transparency of the nuclear medium to kaons from A(e, e K + ) measurements on 12 C, 63 Cu, and 197 Au targets. The measurements were performed at the Jefferson Laboratory and span a range in four-momentum-transfer squared Q 2 = 1.1-3.0 GeV 2 . The nuclear transparency was defined as the ratio of measured kaon electroproduction cross sections with respect to deuterium (σ A /σ D ). We further extracted the atomic number (A) dependence of the transparency as parametrized by T = (A/2) α−1 and, within a simple model assumption, the in-medium effective kaon-nucleon cross sections. The effective cross sections extracted from the electroproduction data were found to be smaller than the free cross sections determined from kaon-nucleon scattering experiments, and the parameter α was found to be significantly larger than those obtained from kaon-nucleus scattering. We have included similar comparisons between pion-and proton-nucleon effective cross sections as determined from electron-scattering experiments and pion-nucleus and proton-nucleus scattering data.