Kann eine linksventrikuläre 
pathologische Hypertrophie bei arterieller Hypertonie von einer 
physiologischen Hypertrophie durch Sport unterschieden werden?

Schannwell, C. M.; Marx, R.; Plehn, Gunnar; Perings, Ch.; Leschke, Matthias; Strauer, B. E.

doi:10.1055/s-2001-11739

Cited by 7 publications

(6 citation statements)

References 12 publications

(22 reference statements)

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“…This theory is supported by the decrease in left ventricular muscle mass after delivery. Physiological hypertrophy is also described in highly trained athletes and can be considered as a normal adaptation to a chronic pressure or volume overload [21]. The overload-induced alterations in left ventricular cells and matrix lead to the diastolic dysfunction documented in our study.…”

Section: Discussionmentioning

confidence: 57%

Left Ventricular Hypertrophy and Diastolic Dysfunction in Healthy Pregnant Women

Schannwell¹,

et al. 2002

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Objective: The purpose of this study was to examine which hemodynamic parameters change under the natural volume overload of pregnancy. Study Design: 46 healthy pregnant women were echocardiographically examined during the course of pregnancy. To evaluate left ventricular diastolic function, mitral inflow and pulmonary venous flow profiles were used. Fractional shortening and left ventricular muscle mass were calculated. Results: In the course of pregnancy the left ventricular muscle mass index increased (from 66 ± 6 to 96 ± 9 g/m²), fractional shortening decreased (from 38 ± 4 to 32 ± 6%) and a disturbed diastolic relaxation pattern was documented. Eight weeks after delivery, all left ventricular systolic and diastolic functional parameters returned to normal values. Conclusion: The natural volume overload in pregnancy leads to a reversible ‘physiological’ left ventricular hypertrophy, a short-term decrease in systolic function and a significant change in left ventricular diastolic function.

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Section: Discussionmentioning

confidence: 57%

Left Ventricular Hypertrophy and Diastolic Dysfunction in Healthy Pregnant Women

Schannwell¹,

et al. 2002

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“…This theory is supported by the decrease in left ventricular mass 8 weeks after delivery. The cardiovascular changes during pregnancy represent one of the forms of physiological hypertrophy and resemble those found with exercise training in long-distance runners [21].…”

Section: Discussionmentioning

confidence: 99%

Alterations of left ventricular function in women with insulin-dependent diabetes mellitus during pregnancy

et al. 2003

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Aims/hypothesis. During pregnancy, eminent cardiovascular changes occur. The aim of the following study was to investigate the course of haemodynamic parameters under the increased volume load during pregnancy and delivery in women with insulin-dependent diabetes mellitus. Methods. We examined 51 pregnant diabetic women and 51 healthy pregnant women. The control group consisted of 51 healthy non-pregnant women. In all women, left ventricular mass and fractional shortening were calculated. To evaluate left ventricular diastolic function, mitral inflow and pulmonary venous flow profiles were analysed. Results. During pregnancy left ventricular mass increased, fractional shortening decreased and diastolic dysfunction was found. While the healthy pregnant women developed signs of disturbed relaxation during pregnancy, pregnant diabetic women showed signs of a disturbed relaxation at the beginning of gestation. Of the pregnant diabetic women, 29 developed a restrictive filling pattern at the 24th week of gestation. The remaining 22 diabetic women had a comparable restrictive filling pattern only during vaginal delivery. In 10 of the 29 pregnant diabetic women dangerous complications were documented, while there were no complications in the healthy pregnant women and the other 22 diabetic pregnant women. Conclusion/interpretation. In healthy women pregnancy results in a reversible physiologic left ventricular hypertrophy, a disturbed relaxation pattern and a temporary decrease of left ventricular systolic function. In contrast, pregnant diabetic women showed a delayed relaxation at the beginning of pregnancy and developed a restrictive filling pattern. The early development of a restrictive filling pattern could indicate complications during delivery in pregnant diabetic women. [Diabetologia (2003) 46:267-275] Keywords Diastolic function, pregnancy, Type 1 diabetes mellitus, echocardiography. namic parameters in the maternal cardiovascular system were evaluated noninvasively by echocardiography [2,3]. In earlier studies, echocardiography was frequently applied in order to describe left ventricular systolic function and cardiac haemodynamics during pregnancy [1,4,5,6,7,8], since it allows assessment of cardiac haemodynamics without endangering the pregnancy. However little data on left ventricular diastolic function during pregnancy has been assessed. Our own working group was able to show that an uncomplicated pregnancy in healthy women with normal left ventricular function causes reversible haemodynamic changes with a passager restrictive filling pattern at delivery [8]. In patients with insulin-dependent Pregnancy causes haemodynamic changes in the cardiovascular system due to the physiological volumeoverload [1]. In former studies, changes in haemody-

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“…Dieser Begriff umfasst F stenosierende Makroangiopathie, F koronare Mikroangiopathie, F ischämische Kardiomyopathie, F linksventrikuläre Hypertrophie [29], F Störungen der Endothelfunktion, F Fibrose des perivaskulären und interstitiellen Gewebes, F erhöhten Sympathikotonus, F degenerative Veränderungen der Aortenklappe.…”

Section: Hypertensiv Bedingte Kardiovaskuläre Organmanifestationenunclassified

“…Solche Arrhythmien kommen bei arterieller Hypertonie in 25 bis 50% der Fäl-le vor [12]. Die Linksherzhypertrophie ist somit kein physiologischer Anpassungsmechanismus an eine chronische Dauerbelastung [29], sondern sie ist ein eigenständiger Risikofaktor für kardiale Ereignisse wie Myokardinfarkt, Herzinsuffizienz und plötzlicher Herztod.…”

Section: Linksventrikuläre Hypertrophieunclassified

Hochdruck und Herzinsuffizienz

2007

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Arterial hypertension is the leading cause of mortality and morbidity with a worldwide prevalence of 26%. Aging increases the incidence of arterial hypertension. Arterial hypertension is the prime example for a chronic disease with asymptomatic beginning, creeping course and fatal outcome. Arterial hypertension is a major cardiovascular risk factor and leads to vascular as well as myocardial manifestations: coronary artery disease, hypertensive microvascular disease, concentric left ventricular hypertrophy as well as perivascular and interstitial fibrosis. In the late stages of the disease, hypertrophy and cardiac failure develop. Arterial hypertension is the leading cause of coronary artery disease and cardiac failure, and coronary artery disease is the cause of heart failure in 50% of cases. Various non-invasive and invasive procedures are available for screening and follow-up. The primary therapeutic target is to reverse cardiac manifestations of arterial hypertension using specific therapeutic algorithms as well as lowering blood pressure. This article covers the pathophysiology of arterial hypertension and cardiac failure, clinical symptoms, diagnostic options and therapeutical goals as well as medicinal options.

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Kann eine linksventrikuläre pathologische Hypertrophie bei arterieller Hypertonie von einer physiologischen Hypertrophie durch Sport unterschieden werden?

Cited by 7 publications

References 12 publications

Left Ventricular Hypertrophy and Diastolic Dysfunction in Healthy Pregnant Women

Left Ventricular Hypertrophy and Diastolic Dysfunction in Healthy Pregnant Women

Alterations of left ventricular function in women with insulin-dependent diabetes mellitus during pregnancy

Hochdruck und Herzinsuffizienz

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