Kank proteins: A new family of ankyrin-repeat domain-containing proteins

Zhu, Yun; Kakinuma, Naoto; Wang, Yong; Kiyama, Ryoiti

doi:10.1016/j.bbagen.2007.09.017

Cited by 47 publications

(61 citation statements)

References 22 publications

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“…Kank1 protein was found to form a new family of proteins with three other members, Kank2, Kank3, and Kank4, based on domain and phylogenetic analyses [2]. The names of the family members and their official symbols (all upper-case letters for human genes and upper-case followed by lower-case letters for other or unspecified species) approved by the Human Genome Organisation (HUGO; http://www.hugo-international.org) are summarized in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Kank proteins: structure, functions and diseases

Kakinuma

Zhu

Wang

et al. 2009

Cell. Mol. Life Sci.

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The Kank family of proteins, Kank1-Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors. Their relationship to diseases such as cancer, and to neuronal and developmental disorders, will be an important subject of future study.

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Section: Introductionmentioning

confidence: 99%

Kank proteins: structure, functions and diseases

Kakinuma

Zhu

Wang

et al. 2009

Cell. Mol. Life Sci.

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“…KANK2 localized to podocyte cell bodies as well as nuclei in rat glomeruli ( Figure 2B and Supplemental Figure 2B). KANK proteins contain a KN motif, which includes potential nuclear localization and export signals (8), and were shown to shuttle between the nucleus and the cytoplasm via a process mediated by nuclear localization and export signals (13). KANK4 localized to podocyte cell bodies and primary processes ( Figure 2C and Supplemental Figure 2C).…”

Section: Mutations In Kank2 Cause Ns In Humansmentioning

confidence: 99%

“…The KANK family proteins, KANK1-KANK4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, ankyrin repeats in the C-terminal region, and an additional motif, the KN motif, at the N-terminus (8).…”

Section: Mutations In Kank2 Cause Ns In Humansmentioning

confidence: 99%

“…In addition, we also discovered rare mutations in the related genes KANK1 and KANK4 in families with NS. KANK proteins are characterized by conserved ankyrin-repeat and coiled-coil domains and a motif (KN motif) at the N-terminus containing potential motifs for nuclear localization and export signals (8). In parallel, we the regulation of small GTPases (1).…”

Section: Introductionmentioning

confidence: 99%

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KANK deficiency leads to podocyte dysfunction and nephrotic syndrome

Gee¹,

et al. 2015

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“…Previously, these proteins have been shown to be involved in the regulation of actin cytoskeleton assembly. By RT-PCR, Zhu et al [20] detected ankrd25 expression in all human tissues studied. This is in line with our RT-PCR results.…”

Section: Discussionmentioning

confidence: 99%

Expression of Novel Podocyte-Associated Proteins sult1b1 and ankrd25

Patrakka

Sistani

et al. 2010

Nephron Exp Nephrol

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Background/Aims: Podocytes have a unique function in the renal ultrafiltration that is achieved by expressing proteins that are highly specific to podocytes. In this study, we identified two novel podocyte-associated proteins. Methods: The expression of sult1b1 and ankrd25 in mouse tissues was studied by RT-PCR. The protein expression was studied by generating polyclonal antibodies that were used in Western blotting and immunohistochemistry. Results: By RT-PCR we detected sult1b1 expression only in glomerular, liver and brain tissues. By immunohistochemistry, sult1b1 was detected in the kidney exclusively in the Golgi apparatus of the podocyte. No expression outside the glomerulus was observed in the kidney. The ankrd25 transcript was detected in most mouse tissues analyzed by RT-PCR. In the kidney, however, immunohistochemistry showed that this protein was expressed only by podocyte, mesangial, and smooth muscle cells. In podocytes, ankrd25 was localized to foot processes. Conclusions: Identification of these two novel glomerulus-associated proteins opens up possibilities to investigate their role in the renal filter physiology and diseases. We speculate that sult1b1 may be involved in the sulfonylation of podocyte protein podocalyxin, whereas ankrd25 may contribute to controlling actin dynamics in podocyte foot processes.

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Kank proteins: A new family of ankyrin-repeat domain-containing proteins

Cited by 47 publications

References 22 publications

Kank proteins: structure, functions and diseases

Kank proteins: structure, functions and diseases

KANK deficiency leads to podocyte dysfunction and nephrotic syndrome

Expression of Novel Podocyte-Associated Proteins sult1b1 and ankrd25

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