Kallikrein Protease Involvement in Skin Pathologies Supports a New View of the Origin of Inflamed Itchy Skin

Eissa, Azza; Diamandis, Eleftherios P.

doi:10.1007/978-3-0348-0157-7_3

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Introduction: Skin Barrier Proteases and Their Inhibitors I1

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2014

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“…KLK5 and the majority of KLKs function as trypsin-like serine proteases, i.e., they cleave after arginine or lysine residues whereas KLK7 is a chymotrypsin-like SP that cleaves after phenylalanine or tyrosine residues. KLK14 exhibits both activities (Eissa and Diamandis, 2011). KLKs are involved in many key aspects of epidermal biology, including desquamation, permeability barrier formation, inflammation and host defense.…”

Section: Introduction: Skin Barrier Proteases and Their Inhibitors Imentioning

confidence: 99%

Netherton syndrome: defective kallikrein inhibition in the skin leads to skin inflammation and allergy

Furio¹,

Hovnanian²

2014

Biological Chemistry

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Netherton syndrome (NS) is an orphan genetic skin disease with a profound skin barrier defect and severe allergic manifestations. NS is caused by loss of function mutations in SPINK5 encoding lympho-epithelial Kazal-type inhibitor (LEKTI), a secreted multi-domain serine protease inhibitor expressed in stratified epithelia. Studies in mouse models and in NS patients have established that unopposed kallikrein 5 activity triggers stratum corneum detachment and activates PAR-2 signaling, leading to the autonomous production of pro-allergic and pro-inflammatory mediators. This emerging knowledge on NS pathogenesis has highlighted a central role for protease regulation in skin homeostasis but also in the complexity of the disease, and holds the promise of new specific treatments.

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Section: Introduction: Skin Barrier Proteases and Their Inhibitors Imentioning

confidence: 99%

Netherton syndrome: defective kallikrein inhibition in the skin leads to skin inflammation and allergy

Furio¹,

Hovnanian²

2014

Biological Chemistry

View full text Add to dashboard Cite

show abstract

Kallikrein Protease Involvement in Skin Pathologies Supports a New View of the Origin of Inflamed Itchy Skin

Cited by 1 publication

References 78 publications

Netherton syndrome: defective kallikrein inhibition in the skin leads to skin inflammation and allergy

Netherton syndrome: defective kallikrein inhibition in the skin leads to skin inflammation and allergy

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