Kallikrein Excretion: Relationship with Maturation and Renal Function in Human Neonates at Different Gestational Ages

Vío, Carlos P.; Olavarría, Fernando; Krause, Sergio; Herrmann, Fernando; Grob, Karin

doi:10.1159/000242700

Cited by 18 publications

(5 citation statements)

References 21 publications

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“…Similar results are reported from other studies [30,32,33,36,37]. The higher U K /U Cr index in premature neonates when compared to full-term neonates is also similar to previous studies [36,38,39].…”

Section: Discussionsupporting

confidence: 91%

The urinary activity of angiotensin-converting enzyme in preterm, full-term newborns, and children

et al. 2006

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The urinary activity of the angiotensin-converting enzyme (U(ACE)) is not yet completely documented in human neonates. We measured the U(ACE) in 36 premature neonates on the 1st day and in the 1st, 2nd, 3rd, and 4th weeks of life, in 22 full-term neonates between the 1st and 2nd days, and in 30 nursing and preschool children between 1 month and 6 years of age. The urinary excretion of sodium (U(Na)/U(Cr)) and the potassium/sodium index (U(K)/U(Na)) were analyzed in the neonates. U(ACE) was greater in premature than in full-term neonates and greater in both than in older children (p<0.001). In the premature neonates, U(ACE) peaked at the 2nd week, the U(Na)/U(Cr) index decreased, and the U(K)/U(Na) index increased between the 1st day and the 2nd week (p<0.001). The U(Na)/U(Cr) index on the 1st day and in the 1st and 2nd weeks was greater in premature than in full-term neonates (p<0.001). There was no significant correlation between the U(ACE) and the U(Na)/U(Cr) index. In conclusion, the U(ACE) profile was shown to be age dependent and related to the postnatal renal development. The increase in U(ACE) activity may reflect the high activity of the neonatal intrarenal renin-angiotensin system (RAS).

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Section: Discussionsupporting

confidence: 91%

The urinary activity of angiotensin-converting enzyme in preterm, full-term newborns, and children

et al. 2006

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“…4). A similar rise in urinary kallikrein excretion is also observed during human development (Vio et al, 1987;Fig. 4).…”

Section: Developmental and Tissue-specific Expression Of The Kallikresupporting

confidence: 75%

“…Ontogeny of renal kallikrein in humans and in rats. The data in the upper panel are from Vio et al (1987), the data in lower panel are from El-Dahr and . GA, gestational age (days); PN, postnatal age (days).…”

Section: Ontogeny Of the Rat Kininogen Genesmentioning

confidence: 99%

Ontogeny of the intrarenal kallikrein-kinin system: Proposed role in renal development

El‐Dahr

1997

Microsc. Res. Tech.

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“…The urinary excretion of kallikrein, as a measure of the renal KKS activity, has been shown to exhibit a developmental increase both in humans [5,6] and in animal models [7]. Renal kallikrein gene transcription and activity was also found to be up-regulated in newborn rats [8].…”

Section: Introductionmentioning

confidence: 99%

Endogenous Bradykinin Regulates Renal Function in the Newborn Rabbit

Tóth-Heyn

Guignard²

1998

Neonatology

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The developmental changes in the activity of the renal kallikrein-kinin system (KKS) are related to the hemodynamic changes occurring in the neonatal kidney. In order to clarify the functional importance of the renal KKS in the developing kidney, the effect of the bradykinin B2 receptor antagonist HOE-140 was investigated in newborn rabbits. Effective blockade of bradykinin effect by HOE-140 was demonstrated in 10 rabbits. In 10 additional animals the subcutaneous injection of 300 µg/kg HOE-140 resulted in an increase in renal vascular resistance with a consequent decrease in renal blood flow. Glomerular filtration rate did not change significantly, while the filtration fraction rose, indicating preferential efferent arteriolar constriction. Urine flow rate increased as well as the fractional excretion of potassium. No change in sodium excretion was observed. The present data suggest a regulatory role for the renal KKS in the immature kidney under basal conditions. By inducing predominant efferent arteriolar vasodilation, the KKS appears to play a key role in regulating the neonatal glomerular microcirculation. This is in sharp contrast with the mature kidney, where the KKS predominantly acts on tubular function as a diuretic-natriuretic factor.

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Kallikrein Excretion: Relationship with Maturation and Renal Function in Human Neonates at Different Gestational Ages

Cited by 18 publications

References 21 publications

The urinary activity of angiotensin-converting enzyme in preterm, full-term newborns, and children

The urinary activity of angiotensin-converting enzyme in preterm, full-term newborns, and children

Ontogeny of the intrarenal kallikrein-kinin system: Proposed role in renal development

Endogenous Bradykinin Regulates Renal Function in the Newborn Rabbit

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