Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis

Siriphak, Saeranee; Chanakankun, Ravinnipa; Proungvitaya, Tanakorn; Roytrakul, Sittiruk; Tummanatsakun, Doungdean; Seubwai, Wunchana; Wongwattanakul, Molin; Proungvitaya, Siriporn

doi:10.3390/molecules26113105

Cited by 7 publications

(6 citation statements)

References 34 publications

(57 reference statements)

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“…Furthermore, Deng et al 10 . and Saeraneere et al 11 . reported that CCDC25 is a potential diagnostic and prognostic marker of hepatocellular carcinoma and cholangiocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…18 A study in nature found that CCDC25 is a plasma membrane-bound extracellular DNA sensor, which can be used as a target molecule for neutrophil extracellular trap (NET)-mediated metastasis to further inhibit cancer cell metastasis. 9 Furthermore, Deng et al 10 and Saeraneere et al 11 reported that CCDC25 is a potential diagnostic and prognostic marker of hepatocellular carcinoma and cholangiocarcinoma. However, the role of CCDC25 in ccRCC remains unclear.…”

Section: Ccdc25 Promotes Activation Of Ilk-nf-κb Signaling Pathwaymentioning

confidence: 99%

“…8 Recent studies have revealed that CCDC25 is a plasma membrane-bound extracellular DNA sensor that has been described as an NET-mediated cancer spread target. 9 Furthermore, Deng et al 10 and Saeraneere et al 11 reported that CCDC25 is a potential diagnostic and prognostic marker of cholangiocarcinoma and hepatocellular carcinoma. Nevertheless, the role of CCDC25 in ccRCC is currently unclear.…”

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confidence: 99%

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Coiled‐coil domain containing 25 (CCDC25) regulates cell proliferation, migration, and invasion in clear cell renal cell carcinoma by targeting the ILK‐NF‐κB signaling pathway

Qian,

Zhao,

Zhang

et al. 2024

The FASEB Journal

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Increasing evidence has demonstrated that the expression of coil domains containing 25 (CCDC25) in various malignancies is abnormally high. However, the potential regulatory role and mechanism of CCDC25 in the development of clear cell renal cell carcinoma (ccRCC) are still unclear. In this experiment, we combined in vitro experiments such as wound healing, CCK8, and transwell assay with in vivo experiments on tumor formation in nude mice to evaluate the effect of CCDC25 on the proliferation, migration, and invasion of renal cancer cells. In addition, we also used Western blotting and qPCR to evaluate the role of CCDC25 in activating the integrin‐linked kinase (ILK)‐NF‐κB signaling pathway. Here, we demonstrate that compared to normal tissues and cell lines, CCDC25 is overexpressed in both human ccRCC tissues and cell lines. After CCDC25 knockdown, it has obvious inhibitory effect on the proliferation, migration, and invasion of cancer cells in vitro and in vivo. In contrast, CCDC25 overexpression promotes these effects. Additionally, we also discovered that CCDC25 interacts with ILK and coordinates the activation of the NF‐κB signaling pathway downstream. Generally, our study suggests that CCDC25 plays a vital role in the development of ccRCC, which also means that it may be a potential therapeutic target for ccRCC.

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“…Furthermore, Deng et al 10 . and Saeraneere et al 11 . reported that CCDC25 is a potential diagnostic and prognostic marker of hepatocellular carcinoma and cholangiocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Section: Ccdc25 Promotes Activation Of Ilk-nf-κb Signaling Pathwaymentioning

confidence: 99%

mentioning

confidence: 99%

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Coiled‐coil domain containing 25 (CCDC25) regulates cell proliferation, migration, and invasion in clear cell renal cell carcinoma by targeting the ILK‐NF‐κB signaling pathway

Qian,

Zhao,

Zhang

et al. 2024

The FASEB Journal

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“…The serum has also emerged as a biospecimen towards prognostic biomarkers exploration (Table 3 ). As such, high levels of tissue Krebs von den Lungen 6 (KL-6 mucin)[ 63 ], cadherin-17 (CDH17)[ 64 ], kallikrein-11[ 65 ], uPAR[ 59 ] and high levels of serum cytokine-induced apoptosis inhibitor 1 (CIAPIN1)[ 66 ], MUC5AC[ 55 ], OPN[ 50 ], S100A6[ 67 ] and uPAR[ 59 , 68 ] were found adverse prognostic factors for CCA patient’s survival. Subjected to meta-analysis, high levels of tissue PD-L1[ 17 ] and tissue protein S100P[ 69 ] were also proposed as potential prognostic markers of CCA.…”

Section: Proteinsmentioning

confidence: 99%

Novel approaches in search for biomarkers of cholangiocarcinoma

Mocan¹,

Ilieș²,

Melincovici³

et al. 2022

WJG

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Cholangiocarcinoma (CCA) arises from the ductular epithelium of the biliary tree, either within the liver (intrahepatic CCA) or more commonly from the extrahepatic bile ducts (extrahepatic CCA). This disease has a poor prognosis and a growing worldwide prevalence. The poor outcomes of CCA are partially explained by the fact that a final diagnosis is challenging, especially the differential diagnosis between hepatocellular carcinoma and intrahepatic CCA, or distal CCA and pancreatic head adenocarcinoma. Most patients present with an advanced disease, unresectable disease, and there is a lack in non-surgical therapeutic modalities. Not least, there is an acute lack of prognostic biomarkers which further complicates disease management. Therefore, there is a dire need to find alternative diagnostic and follow-up pathways that can lead to an accurate result, either singlehandedly or combined with other methods. In the "-omics" era, this goal can be attained by various means, as it has been successfully demonstrated in other primary tumors. Numerous variants can reach a biomarker status ranging from circulating nucleic acids to proteins, metabolites, extracellular vesicles, and ultimately circulating tumor cells. However, given the relatively heterogeneous data, extracting clinical meaning from the inconsequential noise might become a tall task. The current review aims to navigate the nascent waters of the non-invasive approach to CCA and provide an evidence-based input to aid clinical decisions and provide grounds for future research.

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“…The IHC was conducted according to the previously reported procedures [15]. The rabbit polyclonal antibody against human CIAPIN1 (Cat#orb377996, Biorbyt, Cambridge, UK) was used for IHC staining at 1:150 dilution.…”

Section: Immunohistochemistry and Evaluation Of Ciapin1 Expression In...mentioning

confidence: 99%

Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis

Truong

Wongwattanakul

Proungvitaya

et al. 2022

JCM

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Cholangiocarcinoma (CCA), a malignancy of the biliary epithelium, can arise at any point in the biliary system. We previously reported that CIAPIN1 is detectable in the sera and that its overexpression was associated with poor prognosis and metastasis of CCA patients. In this study, we investigated further its expression in CCA tissues, biological functions, and related signaling pathways in CCA cells. First, we examined CIAPIN1 expression in CCA tissues of 39 CCA patients using immunohistochemistry (IHC). Then, CIAPIN1-related proteins expressed in CCA cells were identified using RNA interference (siRNA) and liquid chromatography–mass spectrometry (LC–MS/MS). To predict the functions and signaling pathways of CIAPIN1 in CCA cells, the identified proteins were analyzed using bioinformatics tools. Then, to validate the biological functions of CIAPIN1 in the CCA cell line, transwell migration/invasion assays were used. CIAPIN1 was overexpressed in CCA tissues compared with adjacent noncancerous tissues. Its overexpression was correlated with lymph node metastasis. Bioinformatic analyses predicted that CIAPIN1 is connected to the TGF-β/SMADs signaling pathway via nitric oxide synthase 1 (NOS1) and is involved in the metastasis of CCA cells. In fact, cell migration and invasion activities of the KKU-100 CCA cell line were significantly suppressed by CIAPIN1 gene silencing. Our results unravel its novel function and potential signaling pathway in metastasis of CCA cells. CIAPIN1 can be a poor prognostic factor and can be a promising target molecule for CCA chemotherapy.

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Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis

Cited by 7 publications

References 34 publications

Coiled‐coil domain containing 25 (CCDC25) regulates cell proliferation, migration, and invasion in clear cell renal cell carcinoma by targeting the ILK‐NF‐κB signaling pathway

Coiled‐coil domain containing 25 (CCDC25) regulates cell proliferation, migration, and invasion in clear cell renal cell carcinoma by targeting the ILK‐NF‐κB signaling pathway

Novel approaches in search for biomarkers of cholangiocarcinoma

Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis

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