Kainic acid binding sites in the developing chick optic tectum

Gómez-Barriocanal, Javier; Barat, Ana; Ramı́rez, Galo

doi:10.1016/0197-0186(82)90010-9

Cited by 9 publications

(1 citation statement)

References 20 publications

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“…Alternatively, it is possible that the inability of kainate to trigger gamma oscillations in chick hippocampus is a developmental, rather than an evolutionary, difference. Although it has not been studied specifically in the hippocampus, the expression of kainate receptors in both the optic tectum (Gomez‐Barriocanal et al ., ) and the cerebellum (Miralles et al ., ; Voukelatou et al ., ) is still increasing dramatically over the first 10 days post‐hatching in chicks. If this is the case in the hippocampus as well, it is possible that kainate expression was not mature enough in the few slices in which we attempted to induce gamma oscillations using kainate.…”

Section: Discussionmentioning

confidence: 99%

In vitro characterization of gamma oscillations in the hippocampal formation of the domestic chick

Dheerendra

Lynch

Crutwell

et al. 2018

Eur J of Neuroscience

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Avian and mammalian brains have evolved independently from each other for about 300 million years. During that time, the hippocampal formation (HF) has diverged in morphology and cytoarchitecture, but seems to have conserved much of its function. It is therefore an open question how seemingly different neural organizations can generate the same function. A prominent feature of the mammalian hippocampus is that it generates different neural oscillations, including the gamma rhythm, which plays an important role in memory processing. In this study, we investigate whether the avian hippocampus also generates gamma oscillations, and whether similar pharmacological mechanisms are involved in this function. We investigated the existence of gamma oscillations in avian HF using in vitro electrophysiology in P0-P12 domestic chick (Gallus gallus domesticus) HF brain slices. Persistent gamma frequency oscillations were induced by the bath application of the cholinergic agonist carbachol, but not by kainate, a glutamate receptor agonist. Similar to other species, carbachol-evoked gamma oscillations were sensitive to GABA A , AMPA/kainate and muscarinic (M1) receptor antagonism. Therefore, similar to mammalian species, muscarinic receptor-activated avian HF gamma oscillations may arise via a pyramidal-interneuron gamma (PING)-based mechanism. Gamma oscillations are most prominent in the ventromedial area of the hippocampal slices, and gamma power is reduced more laterally and dorsally in the HF. We conclude that similar micro-circuitry may exist in the avian and mammalian hippocampal formation, and this is likely to relate to the shared function of the two structures.

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Section: Discussionmentioning

confidence: 99%

In vitro characterization of gamma oscillations in the hippocampal formation of the domestic chick

Dheerendra

Lynch

Crutwell

et al. 2018

Eur J of Neuroscience

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Ontogeny of binding sites for [3H]kainic acid in chick and rat cerebellar membranes: A comparative study

1990

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We have analyzed the developmental properties of kainate receptors in cerebellar membranes prepared from chick and rat, two vertebrate species with contrasting patterns of functional maturation. Single populations of binding sites have been characterized in the avian and rodent membranes with apparent dissociation constants (Kd) in the 210-280 nM and 40-55 nM ranges, respectively; the number of binding sites (Bmax) increases with age in both species, reaching a maximum of 187 pmol/mg in the case of 10-day chicks vs. 1.28 pmol/mg in 75-day rats. The ontogenetic profiles of kainate receptors in chick and rat cerebella are in consonance with the patent differences in motor development at birth.

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Modulation of adenosine-induced cAMP accumulation via metabotropic glutamate receptors in chick optic tectum

et al. 1995

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Changes on cyclic adenosine monophosphate (cAMP) levels in response to adenosine and glutamate and the subtype of glutamate receptors involved in this interaction were studied in slices of optic tectum from 3-day-old chicks. cAMP accumulation mediated by adenosine (100 microM) was abolished by 8-phenyltheophylline (15 microM). Glutamate and the glutamatergic agonists kainate or trans-D, L-1-aminocyclopentane-1,3-dicarboxylic acid (trans-ACPD) did not evoke cAMP accumulation. Glutamate blocked the adenosine response in a dose-dependent manner. At 100 microM, glutamate did not inhibit the effect of adenosine. The 1 mM and 10 mM doses of glutamate inhibited adenosine-induced cAMP accumulation by 55% and 100%, respectively. When glutamatergic antagonists were used, this inhibitory effect was not affected by 200 microM 6,7-dihydroxy-2,3,dinitroquinoxaline (DNQX), an ionotropic antagonist, and was partially antagonized by 1 mM (RS)-alpha-methyl-4-carboxyphenylglycine [(RS)M-CPG], a metabotropic antagonist, while 1 mM L-2-amino-3-phosphonopropionate (L-AP3) alone, another metabotropic antagonist, presented the same inhibitory effect of glutamate. Kainate (10 mM) and trans-ACPD (100 microM and 1 mM) partially blocked the adenosine response. This study indicates the involvement of metabotropic glutamate receptors in adenylate cyclase inhibition induced by glutamate and its agonists trans-ACPD and kainate.

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Kainic acid binding sites in the developing chick optic tectum

Cited by 9 publications

References 20 publications

In vitro characterization of gamma oscillations in the hippocampal formation of the domestic chick

In vitro characterization of gamma oscillations in the hippocampal formation of the domestic chick

Ontogeny of binding sites for [3H]kainic acid in chick and rat cerebellar membranes: A comparative study

Modulation of adenosine-induced cAMP accumulation via metabotropic glutamate receptors in chick optic tectum

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