Kainate receptor gene expression in the developing rat brain

Bahn, Sabine; Volk, Benedikt; Wisden, William

doi:10.1523/jneurosci.14-09-05525.1994

Cited by 361 publications

(305 citation statements)

References 57 publications

(99 reference statements)

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“…GluR7 is not expressed in high levels in the hippocampus, but dentate gyrus granule cells show moderate levels of mRNA for GluR7 (Bettler et al, 1992;Lomeli et al, 1992;Wisden and Seeburg, 1993b;Bahn et al, 1994). GluR5 is expressed in low levels in CA1 subregion and is almost absent in other subregions of the hippocampus (Bettler et al, 1990;Wisden and Seeburg, 1993b;Bahn et al, 1994). However, the scattered pattern of the in situ hybridization labeling for the GluR5 mRNA indicates that some interneurons may express high levels of mRNA for GluR5 (Bahn et al, 1994).…”

Section: Distribution Of Mrna For Kainate Receptor Subunits In the Hmentioning

confidence: 99%

“…High levels of KA2 subunits are expressed in all hippocampal subregions (Herb et al, 1992;Wisden and Seeburg, 1993b);Bahn et al, 1994). The presence ofmRNA for KA~ subunits is characteristic of CA3 pyramidal cells, since this kainate receptor subunit is specially abundant in the CA3 subregion, with lower levels in the dentate gyrus (Werner et al, 1991;Herb et al, 1992;Wisden and Seeburg, 1993b;Bahn et al, 1994).…”

Section: Distribution Of Mrna For Kainate Receptor Subunits In the Hmentioning

confidence: 99%

“…Low-affinity kainate receptor subunits are also expressed in the hippocampus. For GluR6, the mRNA is abundant in the dentate gyrus and also in the CA3 subregion (Egebjerg et al, 1991;Wisden and Seeburg, 1993b;Bahn et al, 1994). GluR7 is not expressed in high levels in the hippocampus, but dentate gyrus granule cells show moderate levels of mRNA for GluR7 (Bettler et al, 1992;Lomeli et al, 1992;Wisden and Seeburg, 1993b;Bahn et al, 1994).…”

Section: Distribution Of Mrna For Kainate Receptor Subunits In the Hmentioning

confidence: 99%

“…For GluR6, the mRNA is abundant in the dentate gyrus and also in the CA3 subregion (Egebjerg et al, 1991;Wisden and Seeburg, 1993b;Bahn et al, 1994). GluR7 is not expressed in high levels in the hippocampus, but dentate gyrus granule cells show moderate levels of mRNA for GluR7 (Bettler et al, 1992;Lomeli et al, 1992;Wisden and Seeburg, 1993b;Bahn et al, 1994). GluR5 is expressed in low levels in CA1 subregion and is almost absent in other subregions of the hippocampus (Bettler et al, 1990;Wisden and Seeburg, 1993b;Bahn et al, 1994).…”

Section: Distribution Of Mrna For Kainate Receptor Subunits In the Hmentioning

confidence: 99%

“…GluR5 is expressed in low levels in CA1 subregion and is almost absent in other subregions of the hippocampus (Bettler et al, 1990;Wisden and Seeburg, 1993b;Bahn et al, 1994). However, the scattered pattern of the in situ hybridization labeling for the GluR5 mRNA indicates that some interneurons may express high levels of mRNA for GluR5 (Bahn et al, 1994).…”

Section: Distribution Of Mrna For Kainate Receptor Subunits In the Hmentioning

confidence: 99%

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Kainate receptors in hippocampal CA3 subregion: evidence for a role in regulating neurotransmitter release

Malva

Carvalho

1998

Neurochemistry International

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The hippocampal CA3 subregion of the rat is characteristically enriched in kainate receptors. At the synaptic level, the subcellular localization of these receptors is still a matter of debate. The CA3 pyramidal cells are particularly sensitive to excitotoxicity induced by kainate, which is in agreement with the high levels of kainate receptors in the stratum lucidum of the hippocampal CA3 subregion. Immunocytochemical studies, using antibodies against kainate receptor subunits, clearly demonstrated the presence of postsynaptic kainate receptors. However, it was not possible at the time to identify the activity of postsynaptic kainate receptors as mediators of the synaptic transmission. There are also reports showing the labeling of unmyelinated axons and nerve terminals with antibodies against kainate receptor subunits. The evidence for the presence of presynaptic kainate receptors in the hippocampus is further substantiated by the demonstration that stimulation of kainate receptors in synaptosomes isolated from the rat hippocampal CA3 subregion increases the intracellular free Ca 2÷ concentration ([Ca2+]~) coupled to the release of glutamate. These results support the model proposed by Coyle (1983), in which the excitotoxicity induced by kainate involves the activation of presynaptic kainate receptors, causing the release of glutamate. According to this model, the neurotoxic effect of kainate in the rat hippocampal CA3 subregion involves a direct effect on presynaptic kainate receptors and an indirect effect on postsynaptic glutamate receptors due to the enhanced release of glutamate.

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Section: Distribution Of Mrna For Kainate Receptor Subunits In the Hmentioning

confidence: 99%

Section: Distribution Of Mrna For Kainate Receptor Subunits In the Hmentioning

confidence: 99%

Section: Distribution Of Mrna For Kainate Receptor Subunits In the Hmentioning

confidence: 99%

Section: Distribution Of Mrna For Kainate Receptor Subunits In the Hmentioning

confidence: 99%

Section: Distribution Of Mrna For Kainate Receptor Subunits In the Hmentioning

confidence: 99%

See 3 more Smart Citations

Kainate receptors in hippocampal CA3 subregion: evidence for a role in regulating neurotransmitter release

Malva

Carvalho

1998

Neurochemistry International

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Differential distribution of AMPA receptors and glutamate during pre- and postnatal development in the visual cortex of ferrets

Herrmann

1996

J. Comp. Neurol.

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Immunohistochemical methods were used to study the distribution and time-course of appearance of cells expressing glutamate and alpha-amino-3-hydroxy-5-methyl-4-isoaxazole propionic acid (AMPA)-type glutamate receptors (GluR1 and GluR2/3) during development of the ferret visual cortex. Glutamate is present in many neurons in the ventricular zone, intermediate zone, developing cortical plate, and marginal zone as early as embryonic day (E) 34 (birth is at E41 in ferrets). Glutamate attains its adult distribution coincident with the completion of cellular migration. By contrast, GluR1 immunoreactivity emerges more slowly. By birth, GluR1 immunoreactivity is present only in a few neurons in the marginal zone and ventricular zone but is abundant in the marginal zone and subplate, where synaptogenesis commences. The number and staining intensity of GluR1-positive cells increases dramatically during the first two postnatal weeks and is maximal between the second and third week, before slowly declining to adult levels. Cortical cells immunopositive for GluR2/3 follow a similar pattern, although their distribution differs: GluR2/3-positive cells are mainly pyramidal cells. During the first postnatal week, GluR2/3 is also transiently present in fibers in the intermediate zone, which at this stage contains many thalamocortical and callosal and corticofugal axons. The abundance of glutamate at fetal stages, especially in the ventricular zone, is consistent with the previously proposed role of glutamate in mediating trophic effects in vivo, as previously demonstrated in vitro. The expression of AMPA receptors, as well as their transient overexpression, confirms the results of in situ hybridization studies and may imply a developmental role in neuronal differentiation for these receptors, in addition to their mature role in mediating cortical transmission.

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Synchronized overproduction of AMPA, kainate, and NMDA glutamate receptors during human spinal cord development

Kalb

Fox

1997

J. Comp. Neurol.

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Quantitative receptor autoradiography was used to map the distribution in the developing human spinal cord of the three types of ionotropic glutamate receptors. N-methyl-D-Aspartate (NMDA) receptors were labeled with [3H]glutamate, kainic acid (KA) receptors were labeled with [3H]KA, and alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionate (AMPA) receptors were labeled with [3H]AMPA. In the adult, labeling of all three receptor subtypes is largely restricted to the substantia gelatinosa (SG) in the dorsal horn, with very low level labeling elsewhere in the spinal gray matter. In marked distinction, in late fetal life, high level ligand binding is seen throughout the spinal gray matter. In early postnatal life, binding sites diminish in all regions, but least so in the SG, until the adult pattern emerges. Thus a coordinated transient high level of ionotropic glutamate receptor expression occurs within the developing spinal cord. Saturation analysis of ligand binding shows that the affinity of [3H]KA and [3H]AMPA binding is not developmentally regulated. In contrast, the affinity of [3H]glutamate binding to the NMDA receptor in the fetal ventral horn is three-fold greater than in the adult ventral horn. Thus, in addition to quantitative changes in glutamate receptor expression, qualitative changes occur in the expression of NMDA receptors during development. The distinct glutamate receptor phenotype of fetal and early postnatal spinal cord cells suggests that alterations in the excitable properties of these cells plays an important role in activity-dependent development and in susceptibility to excitotoxic injury.

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Kainate receptor gene expression in the developing rat brain

Cited by 361 publications

References 57 publications

Kainate receptors in hippocampal CA3 subregion: evidence for a role in regulating neurotransmitter release

Kainate receptors in hippocampal CA3 subregion: evidence for a role in regulating neurotransmitter release

Differential distribution of AMPA receptors and glutamate during pre- and postnatal development in the visual cortex of ferrets

Synchronized overproduction of AMPA, kainate, and NMDA glutamate receptors during human spinal cord development

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