Kai-Xin-San Improves Cognitive Impairment via Wnt/β-Catenin and IRE1/XBP1s Signalings in APP/PS1 Mice

Xu, Yan; Lu, Fang-Mei; Xu, Hong-Cai; Zhang, Jie; Hei, Shangyan; Qiu, Yuhui; Cai, Yefeng; Zhang, Shijie; Zhao, Min

doi:10.1089/rej.2022.0063

Cited by 6 publications

(1 citation statement)

References 39 publications

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“…The efficacy and potential pharmacological mechanisms of KXS against AD were evaluated and proven to involve multiple targets, multi components and multiple pathways ( Luo et al, 2020 ; Yi et al, 2020 ). KXS improved cognitive function via regulating SIRT3-mediated neuronal cell apoptosis ( Su et al, 2023 ), activating the Wnt/beta-catenin signaling pathway in APP/PS1 mice and AD rats ( Shan et al, 2023 ; Xu et al, 2023 ). Network pharmacology analysis validated the multi-component and multi-target therapeutic mechanisms of KXS for treatment of AD, involving inhibiting Tau protein hyperphosphorylation, inflammation, and apoptosis ( Jiao et al, 2022 ; Wang et al, 2023 ).…”

Section: Herbal Medicine and Admentioning

confidence: 99%

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Liu,

Li,

Liang

et al. 2024

Front. Pharmacol.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. It severely affects the quality of life of victims. The prevalence of AD has been increasing in recent years. Therefore, it is of great importance to elucidate the pathogenic mechanism of AD and search for effective therapeutic approaches. Gut microbiota dysbiosis, an altered state of gut microbiota, has been well known for its involvement in the pathogenesis of AD. Much effort has been made in searching for approaches capable of modulating the composition of gut microbiota in recent years. Herbal medicines have attracted extensive attention in recent decades for the prevention and treatment of AD. Here, we gave an overview of the recent research progress on the modulatory effects of herbal medicines and herbal formulae on gut microbiota as well as the possible beneficial effects on AD, which may provide new insights into the discovery of anti-AD agents and their therapeutic potential for AD through modulating the composition of gut microbiota.

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