Given an ACM set X of points in a multiprojective space P m × P n over a field of characteristic zero, we are interested in studying the Kähler different and the Cayley-Bacharach property for X. In P 1 × P 1 , the Cayley-Bacharach property agrees with the complete intersection property and it is characterized by using the Kähler different. However, this result fails to hold in P m × P n for n > 1 or m > 1. In this paper we start an investigation of the Kähler different and its Hilbert function and then prove that X is a complete intersection of type (d 1 , ..., dm, d 1 , ..., d n ) if and only if it has the Cayley-Bachrach property and the Kähler different is non-zero at a certain degree. When X has the ( )-property, we characterize the Cayley-Bacharach property of X in terms of its components under the canonical projections.