Kaennacowanols A–C, three new xanthones and their cytotoxicity from the roots of Garcinia cowa

Kaennakam, Sutin; Siripong, Pongpun; Tip‐pyang, Santi

doi:10.1016/j.fitote.2015.03.008

Cited by 41 publications

(33 citation statements)

References 27 publications

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“…54S, Supporting Information), which showed that the num-bers and locations of the hydroxyl groups were key features for xanthones to exhibit cytotoxicity. This observation fitted partly with cell proliferation inhibition activities previously reported [40,41]. The isoprenyl group also played an important role in the cytotoxicity of naturally occurring xanthones [14,42].…”

Section: Resultssupporting

confidence: 88%

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Zhang

et al. 2019

Planta Med

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Six new prenylated xanthones (1–6) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1 and 15–17 showed moderate inhibitory effects on tumor cell growth, with IC50s ranging from 3.7 to 14.7 µM.

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Section: Resultssupporting

confidence: 88%

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Zhang

et al. 2019

Planta Med

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“…α-Mangostin ( 23 ), cowanin ( 24 ), cowanol (25) , garcinone D ( 26 ), β-mangostin ( 27 ), fuscaxanthone C ( 28 ), fuscaxanthone I ( 29 ), kaennacowanol A ( 30 ), jacareubin ( 31 ), fuscaxanthone A ( 32 ), and 1-isomagostin ( 33 ) ( Figure 3 ) were obtained from G. cowa [ 179 ]. To cervical cancer Hela cell line, IC 50 value of cytotoxicities were 13.69, 11.68, 12.19, 22.58, 12.78, inactive, 17.20, 16.70, 11.43, inactive, 34.04 μM, respectively.…”

Section: Bioactivities Of Xanthonesmentioning

confidence: 99%

Chemical and Biological Research on Herbal Medicines Rich in Xanthones

Ruan¹,

Zheng²,

Liu³

et al. 2017

Molecules

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Xanthones, as some of the most active components and widely distributed in various herb medicines, have drawn more and more attention in recent years. So far, 168 species of herbal plants belong to 58 genera, 24 families have been reported to contain xanthones. Among them, Calophyllum, Cratoxylum, Cudrania, Garcinia, Gentiana, Hypericum and Swertia genera are plant resources with great development prospect. This paper summarizes the plant resources, bioactivity and the structure-activity relationships (SARs) of xanthones from references published over the last few decades, which may be useful for new drug research and development on xanthones.

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“…Roots no [47] Kaennacowanol A Garcinia cowa Roots yes [103] Kaennacowanol B Garcinia cowa Roots yes [103] Kaennacowanol C Garcinia cowa Roots yes [103] Kouitchenside A Swertia kouitchensis Whole plant no [104] Kouitchenside B Swertia kouitchensis Whole plant no [104] Kouitchenside C Swertia kouitchensis Whole plant no [104] Kouitchenside D Swertia kouitchensis Whole plant no [104] Kouitchenside E Swertia kouitchensis Whole plant no [104] Kouitchenside F Swertia kouitchensis Whole plant no [104] Kouitchenside G Swertia kouitchensis Whole plant no [104] Kouitchenside H Swertia kouitchensis Whole plant no [104] Kouitchenside I Swertia kouitchensis Whole plant no [104] Kouitchenside J Swertia kouitchensis Whole plant no [104] Mangaxanthone A…”

Section: Hypericum Japonicummentioning

confidence: 99%

Xanthones and Cancer: from Natural Sources to Mechanisms of Action

Klein‐Júnior

Campos

Niero

et al. 2020

Chemistry & Biodiversity

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Xanthones are a class of heterocyclic natural products that have been widely studied for their pharmacological potential. In fact, they have been serving as scaffolds for the design of derivatives focusing on drug development. One of the main study targets of xanthones is their anticancer activity. Several compounds belonging to this class have already demonstrated cytotoxic and antitumor effects, making it a promising group for further exploration. This review therefore focuses on recently published studies, emphasizing their natural and synthetic sources and describing the main mechanisms of action responsible for the anticancer effect of promising xanthones.

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Kaennacowanols A–C, three new xanthones and their cytotoxicity from the roots of Garcinia cowa

Cited by 41 publications

References 27 publications

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Chemical and Biological Research on Herbal Medicines Rich in Xanthones

Xanthones and Cancer: from Natural Sources to Mechanisms of Action

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