Kaempferol Protects Ischemia/Reperfusion-Induced Cardiac Damage Through the Regulation of Endoplasmic Reticulum Stress

Kim, Do‐Sung; Ha, Ki-Chan; Kwon, Dae-Young; Kim, Myung-Sunny; Kim, Hyung‐Ryong; Chae, Soo‐Wan; Chae, Han-Jung

doi:10.1080/08923970701812530

Cited by 58 publications

(41 citation statements)

References 31 publications

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“…In ex vivo-Langendorff experiment, the kaempferol treatment regulated the expression of ER stress proteins-CHOP and GRP78. The kaempferol also improved the post-ischemic LVEDP and LVDP significantly after 20, 30, 40 and 50 min of reperfusion compared with the untreated control hearts, which showed that kaempferol offers protection against I/Rassociated cardiac dysfunction [69].…”

Section: Kaempferolmentioning

confidence: 79%

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Khalil¹,

Sulaiman²,

Boukraâ³

2010

TONUTRAJ

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Honey is being used since long time both in medical and domestic needs, but only recently its antioxidant property has come to limelight. With increasing demand for antioxidant supply in the food, honey is becoming popular as a source of antioxidant since it is rich in phenolic acids and flavonoids and other antioxidants including glucose oxidase, catalase, ascorbic acid, carotenoid derivatives, organic acids, amino acids and proteins. The antioxidants have several preventative effects against different diseases like cancer, cardiovascular diseases, inflammatory disorders, neurological degeneration, wound healing, infectious diseases and aging, which led to search for foods rich in antioxidants. Various studies on antioxidant properties of honey have been done. The present article is a short review on the antioxidant properties of honey and its role against health disorder.

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Section: Kaempferolmentioning

confidence: 79%

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Khalil¹,

Sulaiman²,

Boukraâ³

2010

TONUTRAJ

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“…From previous studies, we also know that Kae relax the cardiovascular smooth muscle and reduce the risk of cardiovascular diseases (Kim et al, 2005;Ruiz et al, 2006). Kim et al also demonstrated that Kae could alleviate I/R-induced cardiac damage (Kim et al, 2008). Thus, the cardioprotection of Kae have been widely concerned.…”

Section: Discussionmentioning

confidence: 96%

Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1

Guo

Liao

Huang

et al. 2015

European Journal of Pharmacology

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“…KM has been highlighted over the past years due to its multifunctional efficacies in various diseases such as Parkinson's disease and cancer. [33][34][35] It has been deemed as a drug for the management of inflammatory processes of airway diseases due to its potent anti-inflammatory and antioxidant characteristics. [33][34][35] In addition, other studies have also been demonstrated that KM can block not only lipopolysaccharideinduced NF-κB signaling but also suppress stress-induced MUC expression.…”

Section: )mentioning

confidence: 99%

“…[33][34][35] It has been deemed as a drug for the management of inflammatory processes of airway diseases due to its potent anti-inflammatory and antioxidant characteristics. [33][34][35] In addition, other studies have also been demonstrated that KM can block not only lipopolysaccharideinduced NF-κB signaling but also suppress stress-induced MUC expression. 31,36,37) However, the beneficial effects of KM on PQ-mediated ROS stress in BEAS-2B cells have not been well elucidated yet.…”

Section: )mentioning

confidence: 99%

Cytoprotective Effect of Kaempferol on Paraquat-Exposed BEAS-2B Cells <i>via</i> Modulating Expression of <i>MUC5AC</i>

Podder

Song

et al. 2014

Biological & Pharmaceutical Bulletin

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Mucins are highly glycosylated secretary proteins produced by most epithelial cells. Hypersecretion of mucins is one of the prominent symptoms of several airway diseases, including asthma, cystic fibrosis, nasal allergy, rhinitis, and sinusitis. Paraquat (PQ), a common herbicide, has been associated with pulmonary damage and is a potent reactive oxygen species (ROS) producer. However, until now the role of PQ on mucin overproduction has not been studied. The aim of this study is to explore how kaempferol (KM), a widely used dietary flavonoid, affects the protection of human PQ-exposed bronchial epithelium BEAS-2B cells by suppressing Mucin gene expression via nuclear factor-kappa B (NF-κB). We observed that PQ generates intracellular ROS, and also induces lipid peroxidation in BEAS-2B cells. Additionally, we found that PQ effectively induces the expression of the MUC5AC gene; however, co-treatment of PQ with KM drastically reduces its expression. Furthermore, we observed that PQ activates NF-κB, while co-treatment with KM occludes its nuclear translocation, and additionally KM repressed the PQ phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in BEAS-2B cells. Based on our data, we believe that KM can suppress the over-expression of the MUC5AC gene. This would contribute to the protection of PQ cytotoxicity to exposed BEAS-2B cells, and allow further study toward a better understanding of ROSassociated diseases.Key words MUC5AC; kaempferol; reactive oxygen species; human bronchial epithelial BEAS-2B cell; nuclear factor-kappa B Several studies have been carried out demonstrating hypersecretion of mucous from respiratory epithelial cells a major pathological event in chronic airway diseases such as chronic obstructive pulmonary diseases or asthma.1,2) These pathological manifestations are governed by the interaction between underlying genetic factors and xenobiotics, which together are responsible for intercellular reactive oxygen species (ROS) production.3) Findings have shown that ROS such as: hydrogen peroxide, superoxide anion, hydroxyl ion are responsible for the initiation and progression of chronic airway diseases via over-expression of Mucin genes.4-6) ROS is a major etiological factor in the pathogenesis of chronic inflammatory airway diseases as it triggers mucin secretion in epithelia. 7)Twenty different MUC genes have been characterized in human airway epithelia, these are then subdivided into membrane-bound and secreted forms.8-11) MUC5AC is a hallmark gene, and considered the most phenotypical gene in respiratory diseases; it accumulates in respiratory tract can lead to symptoms such as chronic cough and excessive sputum production. Previous studies showed that paraquat (PQ) is a potent ROS inducer in different epithelial cell lines [12][13][14] and is associated with cellular cytoxicity. However, there has been no study into whether PQ can induce MUC gene expression or not, so in this study we investigated the effects of PQ on Bronchial epithelial BEAS...

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Kaempferol Protects Ischemia/Reperfusion-Induced Cardiac Damage Through the Regulation of Endoplasmic Reticulum Stress

Cited by 58 publications

References 31 publications

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1

Cytoprotective Effect of Kaempferol on Paraquat-Exposed BEAS-2B Cells <i>via</i> Modulating Expression of <i>MUC5AC</i>

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