Kaempferol protects against cardiovascular abnormalities induced by nitric oxide deficiency in rats by suppressing the TNF-α pathway

Maneesai, Putcharawipa; Potue, Prapassorn; Khamseekaew, Juthamas; Sangartit, Weerapon; Rattanakanokchai, Siwayu; Poasakate, Anuson; Pakdeechote, Poungrat

doi:10.1016/j.ejphar.2023.176112

Cited by 5 publications

(1 citation statement)

References 47 publications

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“…The potential mechanism of rutin in preventing L-NAME-induced cardiovascular changes is due to inhibition of the TNF-α pathway. [ 49 ] AGE, a metabolic byproduct in a high-sugar environment, frequently interacts with the receptor for advanced glycation end products (RAGE). This interaction causes oxidative stress, inflammation, and fibrosis in myocardial and vascular tissue, resulting in a variety of peripheral vascular and cardiovascular issues.…”

Section: Discussionmentioning

confidence: 99%

Exploring the potential mechanism of Simiao Yongan decoction in the treatment of diabetic peripheral vascular disease based on network pharmacology and molecular docking technology

Cao,

Zhang,

Zong

et al. 2023

Medicine

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The study aims to investigate the potential action targets and molecular mechanisms of Simiao Yongan decoction (SMYAD) in treating diabetic peripheral vascular disease (DPVD) by utilizing network pharmacology analysis and molecular docking technology. The components and targets of SMYAD were screened using the TCMSP database, while DPVD-related genes were obtained from the GeneCards, OMIM, and Disgenet databases. After intersecting the gene sets, a Protein-Protein Interaction (PPI) network was established, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were carried out. The practical chemical components and core targets identified were molecularly docked using AutoDock software. A total of 126 active compounds were screened from which 25 main components included quercetin, rutoside, hesperidin, naringin, and β-sitosterol were determined to be the active components most associated with the core targets. A total of 224 common target genes were obtained. Among them, JUN, AKT1, MAPK3, TP53, STAT3, RELA, MAPK1, FOS, and others are the expected core targets of traditional Chinese medicine. The top-ranked GO enrichment analysis results included 727 biological processes (BP), 153 molecular functions (MF), and 102 cellular components (CC). KEGG pathway enrichment analysis involved mainly 178 signaling pathways, such as cancer signaling pathway, AGE-RAGE signaling pathway, interleukin-17 signaling pathway, tumor necrosis factor signaling pathway, endocrine resistance signaling pathway, cell aging signaling pathway, and so on. The molecular docking results demonstrate that the principal chemical components of SMYAD exhibit considerable potential for binding to the core targets. SMYAD has the potential to treat DPVD through various components, targets, and pathways. Its mechanism of action requires further experimental investigation.

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Section: Discussionmentioning

confidence: 99%

Exploring the potential mechanism of Simiao Yongan decoction in the treatment of diabetic peripheral vascular disease based on network pharmacology and molecular docking technology

Cao,

Zhang,

Zong

et al. 2023

Medicine

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The Interplay between Dietary Flavonoids and Gut Microbiota in Protecting against Heart Failure

Zhao,

Gai,

Zhang

et al. 2024

Trends in Food Science & Technology

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Kaempferol Ameliorates Renal Remodelling by Inhibiting the Renin‐Angiotensin System Cascade in Hypertensive Rats

Maneesai,

Iampanichakul,

Potue

et al. 2024

Journal of Food Biochemistry

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Background. Kaempferol is a natural flavonoid with a wide range of pharmacological effects. The current study tested whether kaempferol prevents hypertension‐induced renal remodelling in rats. During the 5 weeks of experiments, rats (n = 7/group) were administered Nω‐nitro‐L‐arginine methyl ester hydrochloride (L‐NAME) (40 mg/kg/day) with either vehicle or kaempferol (20 mg/kg/day) or kaempferol (40 mg/kg/day) or lisinopril (5 mg/kg/day). Results. Kaempferol treatment alleviated haemodynamic changes occurring in hypertensive rats, including increases in systolic and diastolic blood pressure, pulse pressure, mean arterial pressure, and heart rate (p < 0.05). Kaempferol treatment prevented glomerular hypertrophy by reducing the increased glomerular cross‐sectional area, glomerular tuft area, Bowman’s space area, glomerular volume, and the extent of renal tubulointerstitial fibrosis induced by hypertension (p < 0.05). Furthermore, animals in the L‐NAME group showed elevated angiotensin‐converting enzyme (ACE) activity and angiotensin II (Ang II) levels compared to those in the kaempferol‐treated group (p < 0.05). Kaempferol treatment also reverted the elevations in levels of superoxide anions and malondialdehyde and reduced catalase and superoxide dismutase activity in hypertensive rats (p < 0.05). L‐NAME‐treated rats showed overexpression of angiotensin II receptor type 1 (AT1), nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4), and matrix metalloproteinase‐9 (MMP‐9) proteins; conversely, the expression of these proteins was reduced in the kaempferol‐treated group (p < 0.05). Conclusion. Kaempferol treatment alleviated renal remodelling induced in rats by chronic hypertension. These mechanisms may be associated with the inhibition of ACE activity and suppression of the Ang II/AT1 receptor/NOX4/MMP‐9 cell signalling pathway in renal tissue.

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Kaempferol protects against cardiovascular abnormalities induced by nitric oxide deficiency in rats by suppressing the TNF-α pathway

Cited by 5 publications

References 47 publications

Exploring the potential mechanism of Simiao Yongan decoction in the treatment of diabetic peripheral vascular disease based on network pharmacology and molecular docking technology

Exploring the potential mechanism of Simiao Yongan decoction in the treatment of diabetic peripheral vascular disease based on network pharmacology and molecular docking technology

The Interplay between Dietary Flavonoids and Gut Microbiota in Protecting against Heart Failure

Kaempferol Ameliorates Renal Remodelling by Inhibiting the Renin‐Angiotensin System Cascade in Hypertensive Rats

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