Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation

Abstract

Acetaminophen (APAP)-induced liver injury (AILI) has become a growing public health problem. Ferroptosis, an iron-dependent form of cell death associated with lipid peroxide accumulation, has been recently implicated in AILI....

Characterization of PKCα-rutin interactions and their application as a treatment strategy for pulmonary arterial hypertension by inhibiting ferroptosis

“…It is well-known that ROS serve as another pivotal index to evaluate ferroptosis. 43 So, in this study, we also checked the effect of rutin on the ROS level, and found that the ROS levels were increased in the PASMCs under hypoxia, but rutin suppressed the overproduction of ROS, as shown in Fig. 2L.…”

Ferroptosis-Regulated Cell Death as a Therapeutic Strategy for Neurodegenerative Diseases: Current Status and Future Prospects

“…This indicates that KF suppresses ferroptosis via the Nrf2/SLC7A11/GPX4 signaling pathway . Additionally, KF has been found to reverse liver injury and iron overload induced by acetaminophen through its effects on Nrf2 …”

“…76 Additionally, KF has been found to reverse liver injury and iron overload induced by acetaminophen through its effects on Nrf2. 130 Puerarin is an active ingredient found in Pueraria, with several pharmacological activities, such as being anti-inflammatory and an . 131 Recent studies have shown that puerarin protects against myocardium injury via the TLR (Toll-like receptor)4/NF-κB/ JNK signaling pathway.…”

Network pharmacology prediction and molecular docking analysis reveal the mechanism of modified Bushen Yiqi formulas on chronic obstructive pulmonary disease

“…38 The anti-inflammatory pathways of kaempferol include inhibition of NF-κB binding activity, inhibition of IL-6, IL-1β, IL-18, and TNF-α release by myeloid activators, and inhibition of Toll-like receptors by increasing nRF2 regulatory gene mRNA and protein expression. [39][40][41] Luteolin is derived from epimedium, and Chen et al 42 showed that luteolin effectively blocked the activation of NF-κB and AP-1 and inhibited the gene expression of TNF-a, IL-6, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 to achieve the F I G U R E 8 KEGG enrichment analysis of MBYF core targets for COPD.…”

“…Quercetin has also been shown to inhibit the production of inflammatory cytokines and chemokines such as IL‐1β and TNF‐a via mitogen‐activated protein kinase (MAPK) and nuclear factor‐kappa B (NF‐κB) signaling pathways in cells 38 . The anti‐inflammatory pathways of kaempferol include inhibition of NF‐κB binding activity, inhibition of IL‐6, IL‐1β, IL‐18, and TNF‐α release by myeloid activators, and inhibition of Toll‐like receptors by increasing nRF2 regulatory gene mRNA and protein expression 39–41 . Luteolin is derived from epimedium, and Chen et al 42 showed that luteolin effectively blocked the activation of NF‐κB and AP‐1 and inhibited the gene expression of TNF‐a, IL‐6, inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 to achieve the effect of treating inflammatory diseases in the lung.…”