Kaempferol mediated synthesis of gold nanoparticles and their cytotoxic effects on MCF-7 cancer cell line

Raghavan, Bhuvanasree Srinivas; Kondath, Sindhu; Rajaram, A.; Rajaram, Rama

doi:10.1016/j.procbio.2015.08.003

Cited by 68 publications

(29 citation statements)

References 60 publications

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“…These problems in using phytochemicals can be by-passed by conjugating them to gold nanoparticles. For example, kaempferol (a phytochemical) conjugated to gold nanoparticles displayed both significantly higher apoptosis and inhibition of angiogenesis in MCF-7 breast cancer cells as compared to kaempferol alone [ 38 ]. Table 1 lists some of the studies performed to investigate the anti-tumor applications of gold nanoparticles in drug delivery.…”

Section: Gold Nanoparticles As Drug Carriersmentioning

confidence: 99%

Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer

Singh

Pandit

Mokkapati

et al. 2018

IJMS

795

512

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The application of nanotechnology for the treatment of cancer is mostly based on early tumor detection and diagnosis by nanodevices capable of selective targeting and delivery of chemotherapeutic drugs to the specific tumor site. Due to the remarkable properties of gold nanoparticles, they have long been considered as a potential tool for diagnosis of various cancers and for drug delivery applications. These properties include high surface area to volume ratio, surface plasmon resonance, surface chemistry and multi-functionalization, facile synthesis, and stable nature. Moreover, the non-toxic and non-immunogenic nature of gold nanoparticles and the high permeability and retention effect provide additional benefits by enabling easy penetration and accumulation of drugs at the tumor sites. Various innovative approaches with gold nanoparticles are under development. In this review, we provide an overview of recent progress made in the application of gold nanoparticles in the treatment of cancer by tumor detection, drug delivery, imaging, photothermal and photodynamic therapy and their current limitations in terms of bioavailability and the fate of the nanoparticles.

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Section: Gold Nanoparticles As Drug Carriersmentioning

confidence: 99%

Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer

Singh

Pandit

Mokkapati

et al. 2018

IJMS

795

512

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“…The diffraction peaks at 45° and 65° corresponded to the (200) and (220) lattice planes. The diffraction peak at 38° and 78° was indexed to the (111) and (311) reflection of the face-centered cube (fcc) structure of gold 10,22. FTIR analyses were carried out to identify the functional groups present in the products and the chemical interaction between kaempferol and K-AuNCs in Figure 2B.…”

Section: Resultsmentioning

confidence: 99%

“…Among the recently found polyphenols, kaempferol has demonstrated to regulate several types of tumor progression. Many studies have reported the potential anticancer therapy of kaempferol, and it has proven to cause cell cycle arrest in various cancer types including lung, breast, pancreatic, ovarian, chronic myelogenous leukemia, and colon cancer 9,10. Kaempferol elicits anticancer activity by inhibiting phosphatidylinositol-3-kinase (PI3K) and ribosomal s6 kinase.…”

Section: Introductionmentioning

confidence: 99%

<p>Kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells</p>

Govindaraju¹,

Arivazhagan²,

Lee³

et al. 2019

IJN

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Background: Kaempferol (K) is a recognized anticancer drug that can conjugate with small-size gold nanoclusters (AuNCs). Materials and methods: K-AuNCs were synthesized and their use as an anticancer drug was explored using A549 lung cancer cells. Colony formation and cell migration assays were carried out. The morphology of the K-AuNCs treated A549 cells was explored using bio-atomic force microscopy. Results: The K-AuNCs were 1-3 nm in diameter and emitted strong fluorescent at 650 nm following excitation at 550 nm. The stretching and bending nature of the K-AuNCs were analyzed by the Fourier transform infrared spectroscopy. The presence of kaempferol in the AuNCs were confirmed by the PL spectroscopy. Conclusion: The synthesized K-AuNCs mainly targeted and damaged the nuclei of the cancer cells. This composite nanocluster was less toxicity to the normal human cell and higher toxicity to the A549 lunch cancer cell and these material is potential for anticancer drug delivery and bio imaging applications.

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“…Several authors demonstrated that kaempferol and myricetin, found on Bryophyllum spp. hydroethanolic extracts, showed a potent cytotoxic effect against MCF-7 cell line, thus suggesting that both molecules may be the major responsible for such effects observed for this cell line (Jiao and Zhang, 2016;Srinivas Raghavan et al, 2015). Specifically, myricetin has been shown to exert a 7-fold higher cytotoxic activity against MCF-7 than the HeLa cell line (Semwal et al, 2016).…”

Section: Cytotoxic and Hepatotoxic Activitymentioning

confidence: 95%