Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes

Leung, Henry W.C.; Lin, Chia‐Der; Hour, Mann Jen; Yang, Wenhui; Wang, M.-Y.; Lee, H.-Z.

doi:10.1016/j.fct.2007.04.023

Cited by 122 publications

(82 citation statements)

References 23 publications

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“…Kaempferol induced apoptosis in H460 cells which was accompanied by significant DNA condensation and increasing ATP levels. It also changed the expression of Caspase 3 and Apoptosis Inducing Factor (AIF) levels [49]. Bestwick et al reported recently that kaempferol growth inhibitory effect on HL-60 leukemia cells is due to heterogeneous response mainly dominated by cell cycle alternation although some degree of cytotoxicity results from apoptotic as well as nonapoptotic process [50].…”

Section: Role Of Antioxidant In Preventing Cancermentioning

confidence: 99%

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Khalil¹,

Sulaiman²,

Boukraa³

2010

TONUTRAJ

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Honey is being used since long time both in medical and domestic needs, but only recently its antioxidant property has come to limelight. With increasing demand for antioxidant supply in the food, honey is becoming popular as a source of antioxidant since it is rich in phenolic acids and flavonoids and other antioxidants including glucose oxidase, catalase, ascorbic acid, carotenoid derivatives, organic acids, amino acids and proteins. The antioxidants have several preventative effects against different diseases like cancer, cardiovascular diseases, inflammatory disorders, neurological degeneration, wound healing, infectious diseases and aging, which led to search for foods rich in antioxidants. Various studies on antioxidant properties of honey have been done. The present article is a short review on the antioxidant properties of honey and its role against health disorder.

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Section: Role Of Antioxidant In Preventing Cancermentioning

confidence: 99%

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Khalil¹,

Sulaiman²,

Boukraa³

2010

TONUTRAJ

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“…A number of mechanisms underlie the beneficial effects of those compounds, such as oxidative stress reduction [1,2], interactions with various signal transduction pathways [3][4][5], immunomodulation [6,7], and inhibition of certain enzymes [8,9]. Considerable interest in the biological activities of polyphenols has been aroused by, inter alia, the increasing incidence of such civilization diseases as cancer, and the need for efficient and safe prophylaxis and therapy.…”

Section: Introductionmentioning

confidence: 99%

Differentiated impact of procyanidins from evening primrose on human breast cancer cells

et al. 2014

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This study examines some of the biological activities of an evening primrose flavanol preparation (EPFP) against non-invasive human breast cancer cells (MCF-7). The results are compared with those obtained for highly invasive human breast cancer cells (MDAMB-231). The results show, for the first time, that EPFP reduces MCF-7 cell number, IC50 = 75 µM gallic acid equivalents/GAE for 72 h incubation, and reduces migration to 52% of the control value at 100 µM L−1 GAE. EPFP caused favorable changes in Bcl-2/Bax mRNA ratio, which rendered MCF-7 cells more sensitive to apoptosis: the number of apoptotic cells increased 2.2-fold vs. control at 100 µM GAE. Furthermore, 100 µ M L−1 GAE EPFP caused a 1.8-fold reduction in the activity of metalloproteinase-9 (MMP-9) secreted to the culture medium by MCF-7 cells. Moreover, EPFP suppressed the expression of selected genes of matrix metalloproteinases (MMPs), a proliferation marker (Ki67), and vascular endothelial growth factor (VEGF). In conclusion, the results of this study suggest that EPFP may exhibit proapoptotic, antiproliferative, antimigratory, and antimetastatic potential towards both selected human breast cancer cell lines, which is more pronounced in the case of the highly invasive MDA-MB-231 cells.

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“…En la tabla 2 se presenta un resumen de los principales estudios realizados en modelos celulares y animales al respecto 51,52,[54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70] . Un estudio in vivo con ratones a los que se induce cáncer mediante la molécula benzo(a)pireno, presente en el humo del tabaco, muestra la capacidad de la fisetina, un flavonol presente en frutas y hortalizas (fresa, manzana, caqui, uva, cebolla y pepino), para inhibir la proliferación celular y el desarrollo de tumores, gracias a sus propiedades antioxidantes 68 .…”

Section: Flavonoides Y Cáncer De Pulmónunclassified

“…La quercetina, un flavonol presente en gran número de frutas y verduras (tabla 1) ha mostrado in vitro una acción inhibitoria de esta vía 58 . En un estudio in vitro se observó que el kaempferol, flavonol que podemos encontrar en hortalizas como la col rizada o el brócoli (tabla 1), podría inducir apoptosis en células cancerígenas del pulmón H460 afectando a las dos vías metabóli-cas en la apoptosis, las denominadas dependientes e independientes de caspasa 60 . Las caspasas son un grupo de cisteinproteasas (más de 14 en esta familia) involucradas en diversos procesos de muerte celular programada.…”

Section: Flavonoides Y Cáncer De Pulmónunclassified

Flavonoides como agentes quimiopreventivos y terapéuticos contra el cáncer de pulmón

Cabrera

Mach

2012

Rev Esp Nutr Hum Diet

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El objetivo de la presente revisión es estudiar la relación entre los flavonoides y el cáncer de pulmón, postulando que su consumo habitual en la dieta occidental podría resultar beneficioso para proteger a los pacientes contra el cáncer de pulmón. Se realizó una extensa búsqueda de publicaciones científicas recientes en las siguientes bases de datos electrónicas especializadas: PubMed central (PMC)-NCBI, Elsevier Journal, SciELO España, Scirus y Science Direct, incluyendo estudios en células, animales y humanos sobre el efecto de los flavonoides en la prevención y el desarrollo de cáncer de pulmón. Pese a que los estudios in vitro y en modelos animales muestran la capacidad potencial de los flavonoides para actuar contra diferentes tipos de cáncer, y en especial contra el riesgo de padecer cáncer de pulmón, la presencia de datos contradictorios en los estudios epidemiológicos y la falta de estudios clínicos en humanos actualmente impiden realizar recomendaciones dietéticas basadas en la evidencia científica para los pacientes con cáncer de pulmón. Así, los autores del presente artículo recomiendan seguir los consejos de las guías de alimentación saludable, las cuales promocionan el consumo de alimentos ricos en flavonoides y reflejan el conocimiento necesario para tratar a los pacientes con cáncer de pulmón.Erratum in: Rev Esp Nutr Hum Diet. 2013;17(2):91-92Link: http://www.renhyd.org/index.php/renhyd/article/view/6/17

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Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes

Cited by 122 publications

References 23 publications

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Differentiated impact of procyanidins from evening primrose on human breast cancer cells

Flavonoides como agentes quimiopreventivos y terapéuticos contra el cáncer de pulmón

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