Kaempferol has osteogenic effect in ovariectomized adult Sprague–Dawley rats

Trivedi, Ritu; Kumar, Sudhir; Kumar, Avinash; Siddiqui, Jawed A.; Swarnkar, Gaurav; Gupta, Varsha; Kendurker, Amruta; Dwivedi, Anil Kumar; Romero, José R.; Chattopadhyay, Naibedya

doi:10.1016/j.mce.2008.02.027

Cited by 135 publications

(126 citation statements)

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“…Kaempferol has been reported to promote the ALP activity and differentiation of cultured osteoblastic cells in vitro (Miyake et al, 2003;Prouillet et al, 2004), and have osteogenic effect in ovariectomized rats (Trivedi et al, 2008). It has also been found that rutin and its metabolite quercetin and isorhamnetin play a role in inhibiting ovariectomy-induced osteopenia in rats (Horcajada-Molteni et al, 2000), and our result about isorhamnetin further supports its role in anti-osteoporosis.…”

Section: Discussionsupporting

confidence: 77%

Antiosteoporotic compounds from seeds of Cuscuta chinensis

Yang

Chen

Wang

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 77%

Antiosteoporotic compounds from seeds of Cuscuta chinensis

Yang

Chen

Wang

et al. 2011

Journal of Ethnopharmacology

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“…Kaempferol is a flavanoid associated with good skeletal health [43,44]. It has been demonstrated to overcome the deleterious effect on bone density in oestrogen deficiency [43], to exhibit an antiosteoclastogenic effect [45,46] and to promote osteoblast differentiation [42]. Layer-by-layer nano-matrix was prepared by the sequential absorption of two bilayers of sodium alginate and protamine sulphate over the CaCO 3 loaded kaempferol microparticles.…”

Section: Nanotechnology For Osteoporosismentioning

confidence: 99%

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Shukla

Dasgupta

Ranjan

et al. 2017

Biotechnology & Biotechnological Equipment

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The application of nanotechnology in medicine, diagnostics, therapeutics, drug delivery, etc. in order to overcome the limitations faced by these fields has already been established. Anaemia and osteoporosis are two of the most widely prevalent iron and calcium deficiency diseases among women. Conventional drugs for both have their inherent limitations which can be overcome by nanotechnology. Nanonization of drugs has been established as a very efficient way to enhance the bioavailability and absorption of the drug in the gastrointestinal tract. In addition to this, encapsulation of drugs in solid lipid nanoparticles is also employed to increase the stability of the drug in the gastrointestinal tract and to facilitate its controlled release. Nanotechnology is also applied in bone tissue engineering to prepare bone grafts for bone injury. Nanotechnology-based bone grafts have shown to possess enhanced mechanical properties and better biocompatibility and osteoconduction than the conventional bone grafts. This review article highlights the research trends and challenges of nanotechnology based drugs to combat iron deficiency anaemia and osteoporosis. This review outlines the recent research trends in nano-drugs and touches on issues concerning the market, industries and patents pertaining to drugs for anaemia and osteoporosis. To provide the safety and risk factors of nanomaterials, we have briefly highlighted the toxicological aspects of nanomaterials used in drugs.

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“…O kaempferol estimula os osteoblastos induzindo neoformação óssea (Trivedi et al, 2008). Na osteoporose secundária ao uso de glicocorticóides há redução do volume ósseo por mecanismos ainda não bem conhecidos, porém estudos in vitro sugerem efeitos diretos sobre as células osteoblásticas, reduzindo sua população por mecanismos de indução de apoptose (Weinstein et al, 1998;Silvestini et al, 2000), que pode ter sido recuperada pela ação osteogênica do EGb e seus componentes.…”

Section: Resultsunclassified

Efeito do extrato de Ginkgo biloba L., Ginkgoaceae, na osteoporose induzida em ratas Wistar

Lucinda¹,

Vieira²,

Salvador³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:Este trabalho investigou os efeitos do tratamento por vinte dias com extrato de Ginkgo biloba (EGb) na osteoporose induzida por glicocorticóides. Foram utilizadas 36 ratas divididas em seis grupos (n=6): Controle, osteoporose, controle positivo, EGb1 (14 mg EGb/mg/kg/dia), EGb2 (28 mg EGb/kg/dia) e EGb3 (56 mg EGb/kg/dia). Os tratamentos foram realizados por vinte dias, após a indução da osteoporose. Após a eutanásia foram removidos o fêmur e a mandíbula de todos os animais. A mandíbula esquerda foi radiografada digitalmente para avaliação da cortical e do suporte ósseo periodontal (SOP). A análise histomorfométrica foi realizada no fêmur e mandíbula direitos. O grupo controle foi comparado ao grupo osteoporose (Teste t de Student) e os demais grupos foram submetidos a ANOVA, seguido do teste post-hoc de Dunnett. Houve redução significava do SOP mesial, percentual ósseo alveolar (POA) mandibular, percentual ósseo trabecular (POT) do fêmur no grupo osteoporose. Houve aumento do SOP mesial no grupo controle positivo, EGb2 e EGb3. O POA da mandíbula e o POT do fêmur aumentaram nos grupos EGb2 e EGb3. O EGb nas doses de 28 mg/kg e 56 mg/kg recuperou de forma significativa o SOP mesial, o POA da mandíbula e o POT do fêmur. Unitermos:Ginkgo biloba, osteoporose, radiografia, histomorfometria, alendronato de sódio, ratos.ABSTRACT: "Effect of the aqueous extract of Ginkgo biloba L., Ginkgoaceae, in induced osteoporosis in Wistar rats." The objective of this study was to investigate the effect of a 20 day treatment with extract of Ginkgo biloba (EGb) in glucocorticoid-induced-osteoporosis. 36 rats were divided into six groups (n=6): control, osteoporosis, positive control, EGb1 (14 mg EGb/kg/day), EGb2 (28 mg EGb/kg/day) and EGb3 (56 mg EGb/kg/day). Treatments were conducted for twenty days, after osteoporosis was induced. Following euthanasia the femur and mandible of all animals were removed. The left mandible was radiographed to evaluate the cortical and the periodontal bone support (PBS). The histomorphometric analysis was performed on the right mandible and the right femur. The control group was compared with the osteoporosis group (Student's t-test). The other groups were analyzed through ANOVA test followed by Dunnett post-hoc test. There was a significantly reduction in the mesial PBS, in the percentage of the alveolar bone (PAB) of the mandible and percentage of the trabecular bone (PTB) of the femur in the osteoporosis group. There was an increase in the mesial PBS in the positive control group, EGb2 and EGb3. The PAB of the mandible and the PTB of the femur increased in the EGb2 and EGb3 groups. The EGb in the 28 mg/kg and 56 mg/kg doses were effective to increase the mesial PBS, the PAB of the mandible and the PTB of the femur.Keywords: Ginkgo biloba, osteoporosis, radiography, histomorphometric, sodium alendronate, rats. INTRODUÇÃOA osteoporose é caracterizada por uma redução na quantidade de tecido ósseo por unidade de volume (Hallworth, 1998) e por uma deteriorização da microarquitetura deste tecido...

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Kaempferol has osteogenic effect in ovariectomized adult Sprague–Dawley rats

Cited by 135 publications

References 28 publications

Antiosteoporotic compounds from seeds of Cuscuta chinensis

Antiosteoporotic compounds from seeds of Cuscuta chinensis

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Efeito do extrato de Ginkgo biloba L., Ginkgoaceae, na osteoporose induzida em ratas Wistar

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