Kaempferol ameliorates aflatoxin B1 (AFB1) induced hepatocellular carcinoma through modifying metabolizing enzymes, membrane bound ATPases and mitochondrial TCA cycle enzymes

Kulanthaivel, Langeswaran; Rajendran, R.; Subbaraj, Gowtham Kumar; Vijayaprakash, Shanmugam; Balasubramanian, M.

doi:10.1016/s2221-1691(12)60471-7

Cited by 25 publications

(10 citation statements)

References 41 publications

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“…Similarly, enhanced hepatic hexokinase, PGI and aldolase activities in the NDEA group can be attributed to the high cell density observed. Such observations are in accordance with the available literature where enhanced glycolytic enzymes have been linked with chemically induced HCC[ 36 ]. Elevated levels of PGI have recently emerged as an excellent response to cancer and PGI level is used as a marker of metastatic growth in patients[ 37 ].…”

Section: Discussionsupporting

confidence: 93%

Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma

Gupta

Bhatia

Bansal

et al. 2016

WJH

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AIMTo investigate the effect of lycopene extracted from tomatoes (LycT) on ultrastructure, glycolytic enzymes, cell proliferation markers and hypoxia during N-Nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis.METHODSFemale BALB/c mice were randomly divided into four groups: The Control, NDEA (200 mg NDEA/kg b.w. given i.p.), LycT (5 mg/kg b.w. given orally on alternate days) and LycT + NDEA group. The mRNA and protein expression of various cell proliferation markers (PCNA, Cyclin D1, and p21) were assessed by reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay, respectively. The ultrastructure of hepatic tissue was analyzed using scanning and transmission electron microscopy. The enzymatic activity of glycolytic enzymes was estimated using standardized protocols, while glucose-6-phosphate dehydrogenase activity level was estimated using a kit obtained from Reckon Diagnostic P. Ltd. (India).RESULTSUncontrolled proliferation in the liver of NDEA (P ≤ 0.001) mice was evident from the high expression of cell-proliferation associated genes (PCNA, Cyclin D1, and p21) when compared to control and LycT mice. In addition, enhanced activities of hexokinase, phosphoglucoisomerase, aldolase, glucose-6-phosphate dehydrogenase and hypoxia-inducible factor-1α were observed in NDEA mice as compared to control (P ≤ 0.001) and LycT (P ≤ 0.001) mice. The alterations in hepatic ultrastructure observed in the NDEA group correlated with the changes in the above parameters. LycT pre-treatment in NDEA-challenged mice ameliorated the investigated pathways disrupted by NDEA treatment. Moreover, hepatic electron micrographs from the LycT + NDEA group showed increased macrophages, apoptotic bodies and well-differentiated hepatocellular carcinoma (HCC) in comparison to undifferentiated HCC as observed in the NDEA treated group.CONCLUSIONThis study demonstrates that dietary supplementation with LycT has a multidimensional role in preventing HCC development.

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Section: Discussionsupporting

confidence: 93%

Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma

Gupta

Bhatia

Bansal

et al. 2016

WJH

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“…As kaempferol has no cytotoxic effect on normal cells with reported ability to modulate both the expression and function of P‐gp, kaempferol can be a good choice for chemosensitizing the hepatocellular carcinoma cells. Kaempferol treatment at a dose of 100 mg kg/BW/day for 28 successive days ameliorated aflatoxin‐induced hepatocarcinogenesis (Langeswaran et al., 2012). In another rat model of hepatocellular carcinoma, luteolin and kaempferol exhibited significant apoptotic effect in liver cancer cells with no toxicity to healthy hepatocytes and mitochondria (Seydi et al, 2018).…”

Section: Flavonoids In the Chemoprevention And Treatment Of Hepatocellular Carcinomamentioning

confidence: 99%

Cogent role of flavonoids as key orchestrators of chemoprevention of hepatocellular carcinoma: A review

et al. 2021

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Chemopreventive approaches with food‐derived phytochemicals are progressively rising as a significant aspect of tumor management and control. Herein, we have showcased the major phytoconstituents belonging to the group of flavanoid, as anti‐cancer agents used for the treatment and prevention of hepatocellular carcinoma (HCC). Sorafenib is the sole drug used for the treatment of advanced HCC, but its clinical application is limited because of its severe adverse effects and drug resistance. Diet‐based chemoprevention seems to be the way forward for this disease of malignant nature. As HCC is derived from a chronic inflammatory milieu, the regular incorporation of bioactive phytochemicals in the diet will confer protection and prevent progression to hepatocarcinogenesis. Many preclinical studies proved that the health benefits of flavonoids confer cytotoxic potential against various types of cancers including hepatocellular carcinoma. As flavonoids with excellent safety profile are abundantly present in common vegetables and fruits, they can be better utilized for chemoprevention and chemosensitization in such chronic condition. This review highlights the plausible role of the eight most promising flavonoids (Curcumin, Kaempferol, Resveratrol, Quercetin, Silibinin, Baicalein, Galangin and Luteolin) as key orchestrators of chemoprevention in hepatocellular carcinoma with preclinical and clinical evidence. An attempt to address the challenges in its clinical translation is also included. This review also provides an insight into the close association of HCC and metabolic disorders which may further decipher the chemopreventive effect of dietary bioactive from a proof of concept to extensive clinical translation. Practical applications According to GLOBOCAN 2020 database, it is estimated that 905,677 new cases of liver cancer and approximately 830,180 deaths related to that. The cancer incidence and mortality are almost similar as it is diagnosed at an advanced stage in patients where systemic drug therapy is the sole approach. Due to the emergence of multidrug resistance and drug‐related toxicities, most of the patient can not adhere to the therapy regimen. Flavonoids are known to be a potential anticancer agent with an excellent safety profile. These are found to be effective preclinically against hepatocellular carcinoma through modulation of numerous pathways in hepatocarcinogenesis. But, the bioavailability issue, lack of well designed‐validated clinical evidence, the possibility of food–drug interaction etc limit its clinical utility. The research inputs mainly to overcome pharmacokinetic issues along with suitable validation of efficacy and toxicity will be a critical point for establishing flavonoids as an effective, safe, affordable therapeutics.

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“…It might be just a remarkable label sequential digit, or might be item narrated data, for example, a volume quantity understudy digit, or extra particular data. RFID labels enclose no less than 2 sections: a coordinated course for putting away and handling data, balancing and demodulating RF sign, gathering DC control as of the occurrence bookworm sign, supplementary specific capacities; and a receiving wire for accepting and transmitting the gesture [3][4]. Repaired bookworms are locating to make a particular cross examination region which may be firmly proscribed.…”

Section: Radio Frequency Identification Methodsmentioning

confidence: 99%

Elegant System for Library Management using RFID

D¹,

Valarmady²,

Rajasekar³

2018

IJET

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Radio Frequency Identification (RFID) implies a system that exchanges the data remotely, utilizing radio frequency waves. It is programmed identification innovation. This paper is about RFID based system for library management that permits quick exchange stream and will make simple to deal with the exercises like issue and return of books from the library absent much manual intercession. This system depends on RFID readers and detached RFID tags that can store the data electronically which can be perused by the RFID readers. This system will influence clients to issue to and return of books through RFID tags simple and furthermore ascertain the comparing fine connected with the timeframe the nonappearance of the book from the library.

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Kaempferol ameliorates aflatoxin B1 (AFB1) induced hepatocellular carcinoma through modifying metabolizing enzymes, membrane bound ATPases and mitochondrial TCA cycle enzymes

Cited by 25 publications

References 41 publications

Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma

Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma

Cogent role of flavonoids as key orchestrators of chemoprevention of hepatocellular carcinoma: A review

Elegant System for Library Management using RFID

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