Kaempferol: A flavonoid with wider biological activities and its applications

Bangar, Sneh Punia; Chaudhary, Vandana; Sharma, Nitya; Bansal, Vasudha; Özoğul, Fatih; Lorenzo, José M.

doi:10.1080/10408398.2022.2067121

Cited by 51 publications

(36 citation statements)

References 165 publications

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“…So far, research on flavonols has focused mainly on isolation and structure identifi cation, pharmacological activity and signaling pathways and structure-activity relation ship, as well as on the molecular mechanisms of interaction with biological macromole cules [29][30][31]. Although natural flavonols, which are biocompatible and show ESIPT, are particularly suitable as fluorescence-based sensors and biological imaging agents, there has been little research in this area.…”

Section: Discussionmentioning

confidence: 99%

Silver@quercetin Nanoparticles with Aggregation-Induced Emission for Bioimaging In Vitro and In Vivo

Xiao

et al. 2022

IJMS

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Fluorescent materials based on aggregation-induced emission luminogens (AIEgens) have unique advantages for in situ and real-time monitoring of biomolecules and biological processes because of their high luminescence intensity and resistance to photobleaching. Unfortunately, many AIEgens require time-consuming and expensive syntheses, and the presence of residual toxic reagents reduces their biocompatibility. Herein, silver@quercetin nanoparticles (Ag@QCNPs), which have a clear core–shell structure, were prepared by redox reaction of quercetin (QC), a polyphenolic compound widely obtained from plants, including those used as foods, and silver ions. Ag@QCNPs show both aggregation-induced luminescence and the distinct plasma scattering of silver nanoparticles, as well as good resistance to photobleaching and biocompatibility. The Ag@QCNPs were successfully used for cytoplasmic labeling of living cells and for computerized tomography imaging in tumor-bearing mice, demonstrating their potential for clinical applications.

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Section: Discussionmentioning

confidence: 99%

Silver@quercetin Nanoparticles with Aggregation-Induced Emission for Bioimaging In Vitro and In Vivo

Xiao

et al. 2022

IJMS

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“…KMP (3,4′,5,7‐tetrahydroxyflavone), also well‐known as indigo yellow, is a nutritional compound that is amply present in a broad range of plants, including Delphinium, Camellia, berberis, Citrus, Equisetum spp, Sophora japonica, and fruits or vegetables, such as teas, cabbage, broccoli, apples, grapes, citrus fruits, strawberries, beans, tomatoes, and onions (Bangar et al, 2022 ; Imran, Rauf, et al, 2019 ; Imran, Salehi, et al, 2019 ). The presence of phenolic compounds in the chemical structure of the above‐mentioned nutrients has been connected to their therapeutic capacities, especially their antioxidant activity (Bangar et al, 2022 ). The presence of a connection between molecular structure and pharmacological activity always manifests noteworthy information.…”

Section: Kmpmentioning

confidence: 99%

“…The presence of a connection between molecular structure and pharmacological activity always manifests noteworthy information. KMP has been the subject of various empirical and theoretical research among several compounds (Bangar et al, 2022 ). The biological activities of polyphenols stem largely from their molecular shape and relative spatial orientation of phenolic rings and hydroxyl groups.…”

Section: Kmpmentioning

confidence: 99%

“…Flavonoids are one of these most important compounds among polyphenolic secondary metabolites and nutrients which are further categorized into six subclasses as a result of their some extra modifications, including glycosylation and hydroxylation (Dai & Mumper, 2010 ; D'archivio et al, 2007 ). Flavonols, the most popular flavonoids in plant food, are the main subgroup of flavonoids that have appealing biological roles, especially their antioxidative, antibacterial, anti‐inflammatory, and anticancer functions (Bangar et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Kaempferol: A potential agent in the prevention of colorectal cancer

Nejabati

Roshangar

2022

Physiological Reports

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Colorectal cancer (CRC) is the third most prevalent cancer in relation to incidence and mortality rate and its incidence is considerably increasing annually due to the change in the dietary habit and lifestyle of the world population. Although conventional therapeutic options, such as surgery, chemo‐ and radiotherapy have profound impacts on the treatment of CRC, dietary therapeutic agents, particularly natural products have been regarded as the safest alternatives for the treatment of CRC. Kaempferol (KMP), a naturally derived flavonol, has been shown to reduce the production of reactive oxygen species (ROS), such as superoxide ions, hydroxyl radicals, and reactive nitrogen species (RNS), especially peroxynitrite. Furthermore, this flavonol inhibits xanthine oxidase (XO) activity and increases the activities of catalase, heme oxygenase‐1 (HO), and superoxide dismutase (SOD) in a wide range of cancer and non‐cancer cells. Based on several studies, KMP is also a hopeful anticancer which carries out its anticancer action via suppression of angiogenesis, stimulation of apoptosis, and cell cycle arrest. Due to various applications of KMP as an anticancer flavonol, this review article aims to highlight the current knowledge regarding the role of KMP in CRC.

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“…Natural components have been gradually introduced for the treatment of tumors in clinic, not only improving the life quality of cancerous patients but also reducing harmful and toxic effects [ 7 , 8 ]. Kaempferol (KA) is a polyphenolic flavonoid that can be found in multifarious natural substances, such as grapefruit, gingko, tea, propolis, and so on, and displays various medicinal and biological properties [ 9 ]. Numerous studies have suggested that KA has a wealth of health benefits, including antibacterial [ 10 ], anti-asthmatic [ 11 ], anti-inflammatory [ 12 ], stroke prevention [ 13 ], antioxidant [ 14 ], hypoglycemic [ 15 ], and atherosclerosis preventive [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Modified Nanostructured Lipid Carrier for Targeting Delivery of Kaempferol to NSCLC: Preparation, Optimization, Characterization, and Performance Evaluation In Vitro

Liu

Cui

et al. 2022

Molecules

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Lung cancer seriously threatens the health of human beings, with non-small cell lung cancer (NSCLC) accounting for 80%. Nowadays, the potential position of nano-delivery in treating cancer has been the subject of continuous research. The present research aimed to prepare two molecular weight hyaluronic acid (HA)-modified kaempferol (KA)-loaded nanostructured lipid carriers (HA-KA-NLCs) by the method of melting ultrasonic and electrostatic adsorption, and to assess the antitumor effect of the preparations on A549 cells. The characterization and safety evaluation of the preparations illustrated that they are acceptable for drug delivery for cancer. Subsequently, differential scanning calorimetry (DSC) curve and transmission electron microscopy (TEM) images indicated that the drug was adequately incorporated in the carrier, and the particle appeared as a sphere. Moreover, HA-KA-NLC showed predominant in vitro antitumor effects, inhibiting proliferation, migration, and invasion, promoting apoptosis and increasing cellular uptake of A549 cells. Otherwise, the Western blot assay revealed that preparations could activate epithelial-mesenchymal transition (EMT)-related signaling pathways and modulate the expression of E-cadherin, N-cadherin, and Vimentin in A549 cells. Our present findings demonstrated that HA-KA-NLC could be considered as a secure and effective carrier for targeted tumor delivery and may have potential application prospects in future clinic therapy of NSCLC.

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Kaempferol: A flavonoid with wider biological activities and its applications

Cited by 51 publications

References 165 publications

Silver@quercetin Nanoparticles with Aggregation-Induced Emission for Bioimaging In Vitro and In Vivo

Silver@quercetin Nanoparticles with Aggregation-Induced Emission for Bioimaging In Vitro and In Vivo

Kaempferol: A potential agent in the prevention of colorectal cancer

Hyaluronic Acid Modified Nanostructured Lipid Carrier for Targeting Delivery of Kaempferol to NSCLC: Preparation, Optimization, Characterization, and Performance Evaluation In Vitro

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