Kadsuralignans H−K from Kadsura coccinea and Their Nitric Oxide Production Inhibitory Effects

Abstract

One new arylnaphthalene lignan named kadsuralignan H ( 1) and three new dibenzocyclooctadiene lignans, named kadsuralignans I ( 2), J ( 3), and K ( 4), respectively, were isolated from an EtOAc fraction of the 80% acetone extract of Kadsura coccinea. The structures were elucidated on the basis of spectroscopic evidence. Compound 1 is the second arylnaphthalene lignan isolated from the Kadsura genus. Compounds 1 and 3 showed inhibitory activity on nitric oxide (NO) production by the murine macrophage-like cell RAW264.7, which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (INF-gamma).

Lignans from the roots of Kadsura coccinea and their inhibitory activities on LPS-induced NO production

“…The roots of K. coccinea have been an ethnomedicine used for the treatment of cancer, dermatosis, gastroenteric disorders, rheumatoid arthritis and relieving pain (Hu et al, 1999). Previous phytochemical investigations on K. coccinea revealed the main presence of lignans (Hu et al, 2012;Gao et al, 2012;Li et al, 2006Li et al, , 2007 and triterpenoids (Gao et al, 2008a;Li et al, 2008;Liang et al, 2012;Song et al, 2010;Wang et al, 2008Wang et al, , 2012 in this plant, which showed the antiproliferative , anti-hepatitis (Ban et al, 2009) and NO inhibitory activities (Li et al, 2007(Li et al, , 2006. In our continuous survey on the chemical composition of Chinese folk medicines and medicinal plants (Xu et al, 2012;Wang et al, 2013), three new lignans, 14-O-demethyl polysperlignan D (1), kadsurindutin E (16), coccilignan A (17), and fifteen known lignan compounds (2-15 and 18) (Fig.…”

Raman Laser Switching Induced by Cascaded Light Scattering

“…Stimulated light scattering, such as stimulated Raman scattering (SRS) and stimulated Brillouin scattering (SBS), can lead to the generation of coherent photons in different materials and geometries. [1,2] Unlike conventional inversion lasers, the emissions from stimulated-scattering lasers are not limited to specific wavebands since no real energy levels are required; this provides unique advantages in many applications, for example, arbitrary wavelength conversion, [3][4][5] high-quality microwave generation, [6] gyroscopes, [7] sensing, [8][9][10][11][12][13] mode control, [14,15] etc. Considering DOI: 10.1002/lpor.201900138 that the stimulated gain arises from coherent coupling between a pump field and a Stokes field mediated by another field, for example, a phonon field, the newly generated Stokes field may also act as a pump for the generation of further Stokes fields-an effect known as cascaded light scattering (CLS), resulting in cascaded Raman and Brillouin lasers.…”

Microwave‐assisted chemical synthesis of conducting polyindole: Study of electrical property using Schottky junction

“…In this way, a precise nonthermal effects of microwave irradiation can be magnified in controlled way. 6,7 Nowadays researchers have started microwave-assisted synthesis approach for the preparation of various compounds viz. spiroorthoester, phenyl oxazoline, polymers (poly 9,9-dihexylfluorene, polyesters), and polymer composites/copolymers.…”