Kadsura coccinea: A rich source of structurally diverse and biologically important compounds

Yang, Yupei; Hussain, Nusrat; Zhang, Liu; Jia, Yan-Zhe; Jian, Yuqing; Li, Bin; Choudhary, Muhammad Iqbal; Rahman, Atta-ur; Wang, Wei

doi:10.1016/j.chmed.2020.03.006

Cited by 24 publications

(12 citation statements)

References 41 publications

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“…Modern phytochemical research shows that KC contains a variety of ingredients, with lignans and terpenoids being the main ingredients [ 30 ]. More than 202 compounds have been identified, including dibenzocyclooctadiene lignans, Spirobenzofuranoid dibenzocyclooctadiene lignans, Arylnaphthalene lignans, Kadlongilactone triterpenoids, and sesquiterpenoids [ 31 , 32 ]. The dried roots, stems, and leaves of KC have a broad tradition of use in TDM to treat rheumatoid arthritis, duodenal ulcers, gastrointestinal disorders, and gynecological problems.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study on Photo-Protective and Anti-Melanogenic Properties of Different Kadsura coccinea Extracts

Jeon

Kang

Park

et al. 2021

Plants

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Kadsura coccinea (KC), a beneficial plant for human health, has been used for centuries in China, Thailand, and Korea in folk medicine and food. There is evidence supporting the biological effects of highly bioactive ingredients in KC such as lignans, triterpenoids, flavonoids, phenolic acids, steroids, and amino acids. In this study, we aimed to explore the effects, functions, and mechanisms of the extracts from KC root (KCR), stem (KCS), leaf (KCL), and fruit (KCF) in UVA and UVB-irradiated keratinocytes and α-melanocyte stimulating hormone (α-MSH)-stimulated melanocytes. First, the total polyphenol and flavonoid contents of KCR, KCS, KCL, and KCF and their radical scavenging activities were investigated. These parameters were found to be in the following order: KCL > KCR > KCS > KCF. UVA and UVB-irradiated keratinocytes were treated with KCR, KCS, KCL, and KCF, and keratinocyte viability, LDH release, intracellular ROS production, and apoptosis were examined. Our results demonstrated that KC extracts improved keratinocyte viability and reduced LDH release, intracellular ROS production, and apoptosis in the presence UVA and UVB irradiation. The overall photoprotective activity of the KC extracts was confirmed in the following order: KCL > KCR > KCS > KCF. Moreover, KC extracts significantly decreased the intracellular melanin content and tyrosinase activity in α-MSH-stimulated melanocytes. Mechanistically, KC extracts reduced the protein and mRNA expression levels of tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in α-MSH-stimulated melanocytes. In addition, these extracts markedly downregulated myophthalmosis-related transcription factor expression and cAMP-related binding protein phosphorylation, which is upstream of the regulation of Tyrosinase, TRP-1, and TRP-2. The overall anti-melanogenic activity of the KC extracts was established in the following order. KCL > KCR > KCS > KCF. Overall, the KC extracts exert photoprotective and anti-melanogenic effects, providing a basis for developing potential skin-whitening and photoprotective agents.

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Section: Discussionmentioning

confidence: 99%

A Comparative Study on Photo-Protective and Anti-Melanogenic Properties of Different Kadsura coccinea Extracts

Jeon

Kang

Park

et al. 2021

Plants

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“…Kadsura genus, with extensive uses in traditional medicine (Yang et al, 2020), is known as an abundant source of lignans and terpenoids (Yang et al, 2019b), exhibiting several biological functions with beneficial properties, i.e., anti-tumor (Liu et al, 2014), cytotoxic (Hu et al, 2016), anti-HIV (Gao et al, 2008b), antioxidative (Cao et al, 2019), anti-hepatitis (Kuo et al, 2005) and hepatoprotective effects (Liu et al, 2018a). K. coccinea is an important raw material for traditional Chinese medicine.…”

Section: Introductionmentioning

confidence: 99%

“…K. coccinea is an important raw material for traditional Chinese medicine. Different plant parts of K. coccinea, including rhizomes, bark, stem, and fruit, have been widely used as raw ingredients for the formulation of traditional Chinese medicine (Li et al, 2006;Li et al, 2007;Yang et al, 2020) and subsequently utilized for the treatment of ulcer, acute gastroenteritis, rheumatoid arthritis, bruise, pain, and dysmenorrhea (Wang et al, 2020b). However, there is a lack of studies concerning the different parts of the fruit and their potential utilization as dietary or medicinal sources.…”

Section: Introductionmentioning

confidence: 99%

Differential metabolome landscape of Kadsura coccinea fruit tissues and potential valorization of the peel and seed tissues

Gao¹,

Xiong²,

Li³

et al. 2022

Biocell

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Kadsura coccinea (Lem.) is a woody wine plant with a peculiar fruit enriched in important health-promoting compounds. The non-editable part of the fruit, i.e., the seed and peel, represents more than 60% of the fruit and is considered a biowaste. This significantly restricts the development of the K. coccinea fruit industry. Clarifying the metabolic components of the different fruit parts can help to improve the utilization rate and valorization of K. coccinea. Herein, we evaluated K. coccinea fruit peel, pulp, and seed using widely-targeted metabolomics and quantified a set of 736 bioactive compounds from 11 major metabolite classes. The most prominent metabolite classes included lipids, amino acids, flavonoids, and lignans. Furthermore, our results emphasized a significant accumulation of flavonoids in pulp tissues, while alkaloids and lignans were abundant in peel and seed tissues, respectively. A total of 183 metabolites were differentially accumulated among the three tissues. Procyanidin C2, rutinoside, 2-hydroxyoleanolic acid, 5-hydroxymethyluracil, nootkatol, isoquercitrin, isohyperoside, quercetin-7-O-glucoside, hyperin, and rutin showed elevated accumulation in the peel. In the seed, kadsuralignan G, kadcoccilactone A, kadsuralignan H, lysoPE 20:5, iso-schisandrin ethyl alcohol, and kadangustin were significantly enriched. Our results highlight the diverse metabolome composition of K. coccinea fruit parts, which can be further exploited for its valorization in various industries.

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“…So far 202 different compounds have been isolated from this plant. The chemical constituents of this plant have been reported with several different bioactivities, including anti-HIV, anti-tumour, cytotoxic, anti-inflammatory, anti-hepatitis, nitric oxide inhibitory, anti-platelet aggregation, and neuroprotective effects [1,3]. K. coccinea is a rich source of lignans and its derivatives.…”

Section: Introduction *mentioning

confidence: 99%

“…K. coccinea is a rich source of lignans and its derivatives. According to skeleton types, K. coccinea lignans can be divided into four categories, including dibenzoclooctadiene, spirobenzofuranoid dibenzocyclooctadienes, diarylbutanes and arylnaphthalene lignans with 79 compounds [3].…”

Section: Introduction *mentioning

confidence: 99%

Untitled

2022

JST: ETSD

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Natural products and their derivatives represent more than 50% of all the drugs in modern therapeutics. Flavonoids and lignans are a large group of naturally occurring and play a variety of biological activities in plants. Schisandraceae family includes 2 genera, Schisandra and Kadsura with about 39 species of plants. The Kadsura coccinea, belonging to Schisandraceae family, is mainly distributed in the tropical and subtropical regions of South and Southeast Asia. The aim of this study is the isolation and structural elucidation of compounds isolated from the leaves of Kadsura coccinea. For this purpose, five known flavonoid compounds, (+) gallocatechin ( 1), catechin ( 2), (-) epicatechin ( 3), phloretin-2-O-glucoside (4), phloretin-4-O-glucoside ( 5) together with 2-hydroxy-5-methoxyphenyl-O-β-D-glucopyranoside ( 6) and icariside E3 (7) were isolated. Their structures are elucidated by NMR spectroscopic analysis as well as compared with the literature. Especially, compound 6 is the first isolated from this plant.

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Kadsura coccinea: A rich source of structurally diverse and biologically important compounds

Cited by 24 publications

References 41 publications

A Comparative Study on Photo-Protective and Anti-Melanogenic Properties of Different Kadsura coccinea Extracts

A Comparative Study on Photo-Protective and Anti-Melanogenic Properties of Different Kadsura coccinea Extracts

Differential metabolome landscape of Kadsura coccinea fruit tissues and potential valorization of the peel and seed tissues

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