“…Generally,t he installationo fah eteroaromatic group on ah eterocyclic ring may change its biological activity dramatically.Acommonly used approach for the preparation of heteroaryl-substituted heterocycles such as 4-heteroaryl-substitutedp yrazoles and isoxazoles,5 -heteroaryl-substituted pyrimidines and 3-heteroaryl-substituted-3H-benzo [b] [1,4]diazepines is the condensation of a-heteroaryl-substitituted 1,3-diketones with additional reagents like hydrazine,h ydroxylamine, guanidine and o-diaminobenzene( Scheme 1, above). The a-furyl-substituted 1,3-diketone is relatively easy to obtain from a1 ,3-diketone and 2,5-dihydro-2,5-dimethoxyfuran (DHDMF), [2] however no convenient method is available for the preparation of a-thienyl, a-benzofuryl and a-pyrrolyl-substituted 1,3-diketones (Scheme 1, middle). Fore xample,o ne method for the synthesis of these compounds is the cross-coupling of heteroaryl-lead triacetate compounds with 1,3-diketones.…”