K₂CO₃-promoted synthesis of amides from 1-aryl-2,2,2-trifluoroethanones and amines under mild conditions

Abstract

A base-promoted amidation of 1-aryl-2,2,2-trifluoroethanones with amines via Haller–Bauer reaction has been developed. This reaction directly transforms aryl trifluoroethanone into amides without the use of stoichiometric chemical oxidants or transition-metal catalysts.

Sulfur-Mediated Decarboxylative Amidation of Cinnamic Acids via C═C Bond Cleavage

“…Among the nonconventional approaches, several protocols for the construction of amides have also been established via C–C bond cleavage using glyoxalic acids, ketones, 2,2,2-trifluoroethyl carbonyls, etc. (Scheme B) . Strategies for the formation of amides via C–C bond cleavage generally require metal catalysts, specific amines, and oxidants.…”