‘K’ is for ketamine: An FMRI study of the neural correlates of a ketamine-induced psychotic state on word generation

Effects of Psychotic State and Task Demand on Prefrontal Function in Schizophrenia: An fMRI Study of Overt Verbal Fluency

“…For example, Sommer et al (36) found a correlation between the severity of auditory hallucinations in schizophrenia and right prefrontal activation during verbal fluency. Moreover, Callicott et al (31) reported greater prefrontal activation in patients with schizophrenia than in comparison subjects during a verbal working memory task, and we have found that healthy volunteers with positive psychotic symptoms induced by ketamine show greater engagement of prefrontal areas during verbal fluency than when performing the task while taking placebo (65). These observations are consistent with the notion that in patients with impaired prefrontal capacity, additional activation may be needed to maintain normal task performance (31).…”