K-edge subtraction synchrotron X-ray imaging in bio-medical research

Thomlinson, W.; Elleaume, Hélène; Porra, Liisa; Suortti, P.

doi:10.1016/j.ejmp.2018.04.389

Cited by 46 publications

(40 citation statements)

References 103 publications

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“…Although the sample size is restricted by the third crystal area, simultaneous KES-CT is possible by rotating the sample on one vertical axis. This is an advantage of the PXR-based KES compared to the simultaneous KES conducted using a bent-crystal system, referred to as spectral-KES at some SR facilities [26][27][28].…”

Section: Simultaneous Kes Imagingmentioning

confidence: 99%

Performance of K -edge subtraction tomography as an application of parametric x-ray radiation

Hayakawa

Nogami

et al. 2019

Phys. Rev. Accel. Beams

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We developed a novel method for element detection utilizing an x-ray source based on parametric x-ray radiation (PXR), an accelerator-based light source at the Laboratory for Electron Beam Research and Application (LEBRA), Nihon University. The method is a type of K-edge subtraction (KES) imaging that uses the drastic change of x-ray absorption around the K-shell absorption edge of the target element. Using the properties of PXR, simultaneous KES imaging is possible, and can easily be applied to 3-dimensional (3D) computed tomography (CT). We demonstrated the feasibility of simultaneous KES-CT in our previous work. In this study, we investigate the quantitative performance of simultaneous KES imaging for a sample containing the element strontium (Sr) for which the K-edge energy is 16.1 keV. Results of a simultaneous KES-CT experiment employing the LEBRA-PXR source confirm that the imaging method can provide a 3D distribution of the element with a value proportional to the Sr concentration. Concerning sensitivity to element concentration, at least in the region of 0.5%-concentration, the sample was successfully distinguished from the region without Sr in the 3D tomographic image obtained using the element-imaging technique.

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Section: Simultaneous Kes Imagingmentioning

confidence: 99%

Performance of K -edge subtraction tomography as an application of parametric x-ray radiation

Hayakawa

Nogami

et al. 2019

Phys. Rev. Accel. Beams

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“…The success of microCT at synchrotron radiation facilities relies on the specific properties of the X-ray beams delivered by third-generation sources: (a) the possibility of generating beams with a high degree of spatial and temporal coherence allows one to apply phase-contrast imaging techniques; image contrast is originated by phase variations within the sample in addition to the absorption (Bravin et al, 2013); (b) the laminar geometry of the beam, combined with a suitable detector shape and sample-todetector distance, opens the possibility of obtaining almost scatter-free images; and (c) the high flux over a wide energy spectrum allows monochromatizing the beam whenever necessary (Als-Nielsen & McMorrow, 2011). The use of monochromatic radiation has several advantages in imaging: (i) it allows choosing the most suitable energy for a given sample size and composition, thus optimizing the image contrast and/or minimizing the deposited dose; (ii) it permits avoiding the beam-hardening artifacts often arising in images acquired using polychromatic laboratory sources; and (iii) it allows the application, using optimized parameters, of the dual energy imaging technique using X-ray beam sets of energies bracketing the absorption edge of high-atomic-number elements present in the sample (Thomlinson et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Multiscale pink-beam microCT imaging at the ESRF-ID17 biomedical beamline

Mittone

Fardin

Lillo

et al. 2020

J Synchrotron Radiat

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Recent trends in hard X-ray micro-computed tomography (microCT) aim at increasing both spatial and temporal resolutions. These challenges require intense photon beams. Filtered synchrotron radiation beams, also referred to as `pink beams', which are emitted by wigglers or bending magnets, meet this need, owing to their broad energy range. In this work, the new microCT station installed at the biomedical beamline ID17 of the European Synchrotron is described and an overview of the preliminary results obtained for different biomedical-imaging applications is given. This new instrument expands the capabilities of the beamline towards sub-micrometre voxel size scale and simultaneous multi-resolution imaging. The current setup allows the acquisition of tomographic datasets more than one order of magnitude faster than with a monochromatic beam configuration.

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“…Although many of these techniques, e.g. K-edge subtraction imaging (Thomlinson et al, 2018) or phase-contrast imaging (Endrizzi, 2018), provide benefits for medical X-ray imaging, most of them have not been implemented in clinical routines yet. This is mostly because they rely on X-ray properties which are -in contrast to conventional X-ray tubes -only provided by synchrotron radiation like (partial) coherence and/or high brilliance.…”

Section: Introductionmentioning

confidence: 99%

The versatile X-ray beamline of the Munich Compact Light Source: design, instrumentation and applications

et al. 2020

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Inverse Compton scattering provides means to generate low-divergence partially coherent quasi-monochromatic, i.e. synchrotron-like, X-ray radiation on a laboratory scale. This enables the transfer of synchrotron techniques into university or industrial environments. Here, the Munich Compact Light Source is presented, which is such a compact synchrotron radiation facility based on an inverse Compton X-ray source (ICS). The recent improvements of the ICS are reported first and then the various experimental techniques which are most suited to the ICS installed at the Technical University of Munich are reviewed. For the latter, a multipurpose X-ray application beamline with two end-stations was designed. The beamline's design and geometry are presented in detail including the different set-ups as well as the available detector options. Application examples of the classes of experiments that can be performed are summarized afterwards. Among them are dynamic in vivo respiratory imaging, propagation-based phase-contrast imaging, grating-based phase-contrast imaging, X-ray microtomography, K-edge subtraction imaging and X-ray spectroscopy. Finally, plans to upgrade the beamline in order to enhance its capabilities are discussed.

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K-edge subtraction synchrotron X-ray imaging in bio-medical research

Cited by 46 publications

References 103 publications

Performance of K -edge subtraction tomography as an application of parametric x-ray radiation

Performance of K -edge subtraction tomography as an application of parametric x-ray radiation

Multiscale pink-beam microCT imaging at the ESRF-ID17 biomedical beamline

The versatile X-ray beamline of the Munich Compact Light Source: design, instrumentation and applications

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