K-edge subtraction imaging for iodine and calcium separation at a compact synchrotron x-ray source

Kulpe, Stephanie; Dierolf, Martin; Braig, Eva-Maria; Günther, Benedikt; Achterhold, Klaus; Gleich, Bernhard; Herzen, Julia; Rummeny, Ernst J.; Pfeiffer, Franz; Pfeiffer, Daniela

doi:10.1117/1.jmi.7.2.023504

Cited by 7 publications

(6 citation statements)

References 26 publications

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“…To our knowledge, this is the first time that such a systematic study is carried out. Indeed, other studies aimed at exploring the potential of ICS beams in KES imaging, both in mammography [58] and coronary angiography [37,38], were carried out experimentally at a fixed machine setup. These proof-of-principle studies demonstrate the general feasibility of KES imaging with ICS sources, but they considered only a limited number of configurations and the results regarding the coronary angiography were obtained with very high contrast medium concentrations if compared to the actual ones.…”

Section: Discussionmentioning

confidence: 99%

“…The insertion of a filter containing the same material used as contrast agent absorbs the part of the spectrum above the K-edge and shifts the mean energy of the remaining spectrum to lower energies. A dedicated algorithm of reconstruction is then applied to retrieve the contrast image [37,38].…”

Section: Dual-energy Imaging Implementation With Inverse Compton Scatmentioning

confidence: 99%

“…Experiments on X-ray imaging with ICS sources involving contrast agents with (quasi-) monochromatic beam at an energy above the K-edge were reported [44][45][46][47], as well as, subtraction imaging with quasi-monochromatic beam and subsequent added filtration of the same material used as contrast medium [37,38]. Nonetheless, dual-energy KES experiments with ICS have never been reported so far, due to the lack of an effective implementation of a fast dual-energy switch, which might become possible in the future with newly proposed ICS source facilities [35].…”

Section: K-edge Subtraction Imaging With Inverse Compton Sourcesmentioning

confidence: 99%

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Dual-Energy X-ray Medical Imaging with Inverse Compton Sources: A Simulation Study

et al. 2020

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It has been long recognized that dual-energy imaging could help to enhance the detectability of lesions in diagnostic radiology, by removing the contrast of surrounding tissues. Furthermore, X-ray attenuation is material specific and information about the object constituents can be extracted for tissue characterisation, i.e., to assess whether lesions represent a malignant or benign process. However, a true separation between the low and high energy components is not possible with conventional sources because of their broad X-ray spectrum, and the artifacts produced in the subtracted image can be only partially removed. Finally, dose issues have also prevented so far the application of dual-energy techniques within the clinical context. Very recently, a new intense and monochromatic X-ray source was proposed to fill the gap between a synchrotron radiation facility and the standard X-ray tube. Indeed, inverse Compton scattering (ICS) sources, which are based on the interaction of a powerful laser beam and a bright beam of relativistic electrons, are among the most promising innovative sources of monochromatic X and gamma radiation. In this contribution, we review the main features that allow an ICS source to meet the requirements of a medical imaging application. Specific examples of K-edge subtraction are then provided, to show the potential of ICS in clinical applications that require intravenous injection of a contrast medium.

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Section: Discussionmentioning

confidence: 99%

Section: Dual-energy Imaging Implementation With Inverse Compton Scatmentioning

confidence: 99%

Section: K-edge Subtraction Imaging With Inverse Compton Sourcesmentioning

confidence: 99%

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Dual-Energy X-ray Medical Imaging with Inverse Compton Sources: A Simulation Study

et al. 2020

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“…Another study [64] concentrated on the issue in clinical radiography that iodine contrast agent cannot be distinguished from calcification since the attenuation values of iodine and calcium are usually very similar or even identical. To demonstrate the ability of KES to separate iodine and calcium in projection imaging, both a study with a phantom containing the two materials and a study of a human carotid artery with calcification and a sodium iodide solution were carried out.…”

Section: Kes Applications In Biomedical Research At Inverse Compton X-ray Sourcesmentioning

confidence: 99%

Spectroscopic imaging at compact inverse Compton X-ray sources

et al. 2020

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While K-edge subtraction (KES) imaging is a commonly applied technique at synchrotron sources, the application of this imaging method in clinical imaging is limited although results have shown its superiority to conventional clinical subtraction imaging. Over the past decades, compact synchrotron X-ray sources, based on inverse Compton scattering, have been developed to fill the gap between conventional X-ray tubes and synchrotron facilities. These so called inverse Compton sources (ICSs) provide a tunable, quasi-monochromatic X-ray beam in a laboratory setting with reduced spatial and financial requirements. This allows for the transfer of imaging techniques that have been limited to synchrotrons until now, like KES imaging, into a laboratory environment. This review article presents the first studies that have successfully performed KES at ICSs. These have shown that KES provides improved image quality in comparison to conventional X-ray imaging. The results indicate that medical imaging could benefit from monochromatic imaging and KES techniques. Currently, the clinical application of KES is limited by the low K-edge energy of available iodine contrast agents. However, several ICSs are under development or already in commissioning which will provide monochromatic X-ray beams with higher X-ray energies and will enable KES using high-Z elements as contrast media. With these developments, KES at an ICS has the ability to become an important tool in pre-clinical research and potentially advancing existing clinical imaging techniques.

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“…X-ray imaging tests with ICS sources using contrast agents have been reported with (quasi-)monochromatic beam at a single energy above the K-edge of iodine [16,17], as well as using filtration of the same material used as contrast medium and specific reconstruction algorithms [18,19]. Also, simulations of the application of KES technique with X-ray beams of proposed ICS facilities demonstrated the potential of these sources in the case of coronary angiography and contrast-enhanced dual-energy mammography [20,21].…”

Section: Introductionmentioning

confidence: 99%

A new method for spatial mode shifting of a stabilized optical cavity for the generation of dual-color X-rays

Suerra,

Giannotti,

Canella

et al. 2021

Preprint

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K-edge subtraction imaging for iodine and calcium separation at a compact synchrotron x-ray source

Cited by 7 publications

References 26 publications

Dual-Energy X-ray Medical Imaging with Inverse Compton Sources: A Simulation Study

Dual-Energy X-ray Medical Imaging with Inverse Compton Sources: A Simulation Study

Spectroscopic imaging at compact inverse Compton X-ray sources

A new method for spatial mode shifting of a stabilized optical cavity for the generation of dual-color X-rays

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