K Antigens of Escherichia Coli and Renal Involvement in Urinary-Tract Infections

Glynn, A. A.; Brumfitt, W.; Howard, C.J.

doi:10.1016/s0140-6736(71)91123-8

Cited by 92 publications

(33 citation statements)

References 13 publications

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“…The most frequently found types are KI, K2, K3, K5, K12 and K13 (Mabeck, 0rskov & 0rskov, 1971a;0rskov et al 1982a). Glynn & Howard (1970) and McCabe et al (1975) demonstrated that the K antigen was present in larger quantities in urinary strains than in strains from faeces; strains from the upper urinary tract were particularly rich in K antigen (Glynn, Brumfitt & Howard, 1971;Brooks et al 1980). The K antigens were not serologically typed.…”

Section: Urinary Tract Infections (Uti)mentioning

confidence: 99%

Escherichia coliin extra-intestinal infections

Ørskov

1985

J. Hyg.

220

162

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When Theodor Escherich (1885a, b) first describedEscherichia colihe looked on it as a saprophytic organism. Soon several investigators found that colibacteria could be isolated from intestinal infections and from many infections outside the intestine, like urinary tract infections (UTI), cholecystitis, wound infections, meningitis, septicaemia, pulmonary infections, and many more. Uhlenhuth (1897) showed that coli strains from pathological processes were more pathogenic in animal experiments than strains isolated from the normal intestine. Smith (1927), who examined strains from white scours in calves, showed that spontaneous acapsular mutants could be obtained from certain colibacteria, and that such mutants were less virulent when injected intra-peritoneally into guinea-pigs.

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Section: Urinary Tract Infections (Uti)mentioning

confidence: 99%

Escherichia coliin extra-intestinal infections

Ørskov

1985

J. Hyg.

220

162

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“…Association between pathogenicity and capsule size has been studied in several other bacterial species, e.g., Escherichia coli (Glynn et d., 1971;McCabe et al, 1975;Verweij-van Vught et al, 1983), pneumococcus (MacLeod and Krauss, 1950) and Staphylococcus aureus (Melly et al, 1974). One mechanism whereby the increased virulence of encapsulated bacteria might be explained is the ability of the capsule or K antigen to prevent the killing of bacteria by serum and their phagocytosis by polymorphonuclear leukocytes (PMNL) as has been shown in particular for E. coli (Howard and Glynn, 1971;Rottini et al, 1975;Van Dijk et al, 1979;Verweij-van Vught et al, 1984). Although the Received 10 May 1985;accepted 25 Jun.…”

Section: Introductionmentioning

confidence: 99%

The role of K antigens as virulence factors in Klebsiella

Simoons-Smit

Vught

Maclaren

1986

Journal of Medical Microbiology

124

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Summary. The importance of K antigen of Klebsiella as a virulence factor was studied in nine pairs of K + and K-strains, each pair isogenic apart from the.presence of K antigen. Loss of K antigen by nine K + strains resulted in the reduced virulence of their K-variants in a mouse-skin model. This reduced virulence of K-strains for mice may be explained in all strains by a higher degree of phagocytosis as measured by chemiluminescence response of human polymorphonuclear leukocytes (PMNL) and in most strains by enhanced killing by either human PMNL or human serum or both. Although the protective role of the K antigen in serum-induced killing and killing by PMNL was generally evident, our results also suggested that other virulence factors were sometimes involved.

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“…The prevalence theory holds that the E. coli strains causing infection are those predominant in the faeces (Turck, Petersdorf & Fournier, 1962; Griineburg, Leigh & Brumfitt, 1968 hand, many investigators have suggested that the infecting E. coli strains are a select group with properties which especially enable them to infect the urinary tract: special pathogenicity theory. The properties that have been related to nephropathogenicity include 0 antigen (Griuneberg, Leigh & Brumfitt, 1968;Mabeck, Orskov & 0rskov, 1971;Dootson, MacLaren & Titcombe, 1973), K antigen (Glynn, Brumfitt & Howard, 1971;Kaijser, 1973;Kalmanson et al 1975;Brooks et al 1980Brooks et al , 1981, haemolysin production (Vahlne, 1945;Cooke & Ewins, 1975;Minshew et al 1978;Brooks et al 1980Brooks et al , 1981 and adhesive capacity (Svanborg Eden, 1978;Varian & Cooke, 1980;Hagberg et al 1981).…”

Section: Introductionmentioning

confidence: 99%

Virulence of urinary and faecalEscherichia coliin relation to serotype, haemolysis and haemagglutination

Bosch

Postma

Koopman

et al. 1982

J. Hyg.

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SUMMARYThe virulence offaecal and urinary Escherichia coli strains was studied in relation to serotype, haemolysin production and haemagglutination pattern. By means of an experimental mouse model E. coli strains can be divided into avirulent (I), mouse nephropathogenic (II), and generally virulent (III) strains. Virulent group II and group III strains were more often haemolytic and haemagglutinating than avirulent group I strains. Presence of K antigen could not be associated with virulence. Discriminant analysis for qualitative variables revealed that no combination of the investigated properties contributed more to a strain's virulence level than did one single property. It is concluded that other virulence factors, apart from haemolysin production in group II strains and haemagglutinins in group III strains, must be involved in the determination of a strain's virulence level.All 02, 06 and 018 ac strains tested were virulent, and by far the most 075 strains were avirulent, whereas other 0 groups were more variable with regard to virulence. Pyelonephritis strains were more often mannose-resistant haemagglutinating than faecal and other urinary isolates, indicating that mannoseresistant adhesins may be important in the pathogenesis of pyelonephritis.

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K Antigens of Escherichia Coli and Renal Involvement in Urinary-Tract Infections

Cited by 92 publications

References 13 publications

Escherichia coliin extra-intestinal infections

Escherichia coliin extra-intestinal infections

The role of K antigens as virulence factors in Klebsiella

Virulence of urinary and faecalEscherichia coliin relation to serotype, haemolysis and haemagglutination

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