K antigen and serum sensitivity of rough Escherichia coli

Opal, Steven M.; Cross, Alan S.; Gemski, P.

doi:10.1128/iai.37.3.956-960.1982

Cited by 52 publications

(25 citation statements)

References 21 publications

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“…The results support the importance of 018 structure in protecting bacteria from serum killing [21]. Kl-negative derivatives of serum-resistant rough parental strains are extremely sensitive to serum [19,22,23]. It has been postulated that the amount of capsule would correlate with the level of serum resistance conferred on rough bacteria [24,25].…”

Section: Properties Of the Kl-defective Mutantssupporting

confidence: 62%

A rapid turbidimetric assay for the study of serum sensitivity of Escherichia coli

Pelkonen

1987

FEMS Microbiology Letters

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Section: Properties Of the Kl-defective Mutantssupporting

confidence: 62%

A rapid turbidimetric assay for the study of serum sensitivity of Escherichia coli

Pelkonen

1987

FEMS Microbiology Letters

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“…To date, the exact mechanism underlying bacterial serum resistance is unknown. Aside from various proteins of the outer membrane, such as the TraT lipoprotein or porins (3,155), primarily CPS and O antigens (lipopolysaccharides [LPS]) have been implicated (49,173,194,230,237,246,252). For Klebsiella, two hypotheses have been propounded (145).…”

Section: Serum Resistance and Lipopolysaccharidementioning

confidence: 99%

Klebsiellaspp. as Nosocomial Pathogens: Epidemiology, Taxonomy, Typing Methods, and Pathogenicity Factors

1998

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SUMMARY Bacteria belonging to the genus Klebsiella frequently cause human nosocomial infections. In particular, the medically most important Klebsiella species, Klebsiella pneumoniae, accounts for a significant proportion of hospital-acquired urinary tract infections, pneumonia, septicemias, and soft tissue infections. The principal pathogenic reservoirs for transmission of Klebsiella are the gastrointestinal tract and the hands of hospital personnel. Because of their ability to spread rapidly in the hospital environment, these bacteria tend to cause nosocomial outbreaks. Hospital outbreaks of multidrug-resistant Klebsiella spp., especially those in neonatal wards, are often caused by new types of strains, the so-called extended-spectrum-β-lactamase (ESBL) producers. The incidence of ESBL-producing strains among clinical Klebsiella isolates has been steadily increasing over the past years. The resulting limitations on the therapeutic options demand new measures for the management of Klebsiella hospital infections. While the different typing methods are useful epidemiological tools for infection control, recent findings about Klebsiella virulence factors have provided new insights into the pathogenic strategies of these bacteria. Klebsiella pathogenicity factors such as capsules or lipopolysaccharides are presently considered to be promising candidates for vaccination efforts that may serve as immunological infection control measures.

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“…The K54 antigen has also been implicated in human serum survival (Russo et al, 1993). Not all K antigens confer serum resistance; studies carried out with K27 and K15 found no protective effect (Opal et al, 1982;Schneider et al, 2004). The association of capsule with pathogenesis in the urinary tract and bloodstream makes it an attractive target for novel therapeutics.…”

Section: The Role Of Polysaccharides In Serum Resistancementioning

confidence: 99%

Bacterial self-defence: howEscherichia colievades serum killing

Miajlović

Smith

2014

FEMS Microbiol Lett

119

107

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The ability to survive the bactericidal action of serum is advantageous to extraintestinal pathogenic Escherichia coli that gain access to the bloodstream. Evasion of the innate defences present in serum, including complement and antimicrobial peptides, involves multiple factors. Serum resistance mechanisms utilized by E. coli include the production of protective extracellular polysaccharide capsules and expression of factors that inhibit or interfere with the complement cascade. Recent studies have also highlighted the importance of structural integrity of the cell envelope in serum survival. These survival strategies are outlined in this review with particular attention to novel findings and recent insights into well-established resistance mechanisms.

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K antigen and serum sensitivity of rough Escherichia coli

Cited by 52 publications

References 21 publications

A rapid turbidimetric assay for the study of serum sensitivity of Escherichia coli

A rapid turbidimetric assay for the study of serum sensitivity of Escherichia coli

Klebsiellaspp. as Nosocomial Pathogens: Epidemiology, Taxonomy, Typing Methods, and Pathogenicity Factors

Bacterial self-defence: howEscherichia colievades serum killing

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