Juxtaposition between two cell types is necessary for dorsal appendage tube formation

Ward, Ellen J.; Berg, Celeste A.

doi:10.1016/j.mod.2004.10.006

Cited by 65 publications

(113 citation statements)

References 53 publications

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“…In fact, ectopic expression of rhomboid throughout the follicular epithelium can result in dorsalized eggs (Ruohola-Baker et al, 1993). However, follicle cell clones ectopically expressing rhomboid have a nonautonomous effect on cell fate (Ward and Berg, 2005), consistent with the production of a diffusible molecule like Spi, and therefore differ markedly from cic mutant clones, suggesting that rhomboid is not a Cic target.…”

Section: Research Articlementioning

confidence: 99%

Capicua regulates follicle cell fate in theDrosophilaovary through repression ofmirror

et al. 2006

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The dorsoventral axis of the Drosophila egg is established by dorsally localized activation of the epidermal growth factor receptor (Egfr)in the ovarian follicular epithelium. Subsequent positive- and negative-feedback regulation generates two dorsolateral follicle cell primordia that will produce the eggshell appendages. A dorsal midline domain of low Egfr activity between the appendage primordia defines their dorsal boundary, but little is known about the mechanisms that establish their ventral limit. We demonstrate that the transcriptional repressor Capicua is required cell autonomously in ventral and lateral follicle cells to repress dorsal fates, and functions in this process through the repression of mirror. Interestingly, ectopic expression of mirror in the absence of capicua is observed only in the anterior half of the epithelium. We propose that Capicua regulates the pattern of follicle cell fates along the dorsoventral axis by blocking the induction of appendage determinants, such as mirror, by anterior positional cues.

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Section: Research Articlementioning

confidence: 99%

Capicua regulates follicle cell fate in theDrosophilaovary through repression ofmirror

et al. 2006

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“…As mentioned in the previous section, one of the main regulators of rho is BR, which represses rho in cells that form the upper part of the future dorsal appendages (11,43). At this point of oogenesis, br is regulated by the brL enhancer.…”

Section: From D Melanogaster To Other Speciesmentioning

confidence: 89%

“…Indeed, the wild-type expression of rho in both species can be predicted by the expression pattern of br. In both species, rho is expressed at the anterior border of the br domain (11,21,30,43). If this is correct, then the regulatory region of brL should be changed in a way that alters the lateral extent of its activity.…”

Section: From D Melanogaster To Other Speciesmentioning

confidence: 99%

“…2). Most importantly, it was established that each of the two dorsal appendages is derived from a 2D primordium comprising a patch of cells expressing the Zn-finger transcription factor Broad (BR) and an adjacent L-shaped stripe of cells that express rhomboid (RHO), which encodes a ligand-processing enzyme in the Drosophila EGFR pathway (11). Cells that express BR and RHO form the top and bottom parts of the future dorsal appendages, respectively (Fig.…”

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confidence: 99%

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Gene regulation during Drosophila eggshell patterning

Pyrowolakis

Veikkolainen

Yakoby

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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A common path to the formation of complex 3D structures starts with an epithelial sheet that is patterned by inductive cues that control the spatiotemporal activities of transcription factors. These activities are then interpreted by the cis-regulatory regions of the genes involved in cell differentiation and tissue morphogenesis. Although this general strategy has been documented in multiple developmental contexts, the range of experimental models in which each of the steps can be examined in detail and evaluated in its effect on the final structure remains very limited. Studies of the Drosophila eggshell patterning provide unique insights into the multiscale mechanisms that connect gene regulation and 3D epithelial morphogenesis. Here we review the current understanding of this system, emphasizing how the recent identification of cis-regulatory regions of genes within the eggshell patterning network enables mechanistic analysis of its spatiotemporal dynamics and evolutionary diversification. It appears that cis-regulatory changes can account for only some aspects of the morphological diversity of Drosophila eggshells, such as the prominent differences in the number of the respiratory dorsal appendages. Other changes, such as the appearance of the respiratory eggshell ridges, are caused by changes in the spatial distribution of inductive signals. Both types of mechanisms are at play in this rapidly evolving system, which provides an excellent model of developmental patterning and morphogenesis.enhancer | network | evolution | signal | dynamics

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“…The elaborate signaling mechanisms that govern follicle cell migration, particularly of the border cells and those secreting dorsal appendages, have been studied in some detail (Dorman et al, 2004;Starz-Gaiano and Montell, 2004;Berg, 2005;Ward and Berg, 2005). Mutations causing defects in the integrity or epithelial polarity of the follicle cells frequently lead to over-proliferation, as well as disorganized, multilayered growth and subsequent degeneration of the egg chamber during mid-oogenesis (reviewed by Mü ller, 2000;Tepass et al, 2001;Bilder, 2004;Horne-Badovinac and Bilder, 2005).…”

Section: Introductionmentioning

confidence: 99%

Expression of 18‐wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila

Kleve

Siler

Syed

et al. 2006

Developmental Dynamics

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The Drosophila ovary is a model system for examining the genetic control of epithelial morphogenesis. The somatic follicle cells form a polarized epithelium surrounding the 16-cell germ line cyst. The integrity of this epithelium is essential for the successful completion of oogenesis. Reciprocal signaling between germ line and somatic cells establishes embryonic and eggshell polarity. The follicle cells are responsible for shaping the egg and secreting the eggshell. Follicle cells at the boundary between the nurse cells and the oocyte migrate centripetally to cover the anterior end of the oocyte and secrete the operculum. Dorsal anterior main body follicle cells undergo elaborate patterning to produce the dorsal appendages. We have examined the expression of the Toll-like receptor, 18-wheeler (18w), in the ovary and find it to be restricted to subpopulations of follicle cells. Females carrying loss-of-function 18w mutant clones in their ovaries show delayed follicle cell migrations. The eggs laid by such females also show morphological defects in egg shape and dorsal appendage morphology. We propose that the 18W protein plays an adhesive or signaling role in regions of the epithelium engaged in cell migration.

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Juxtaposition between two cell types is necessary for dorsal appendage tube formation

Cited by 65 publications

References 53 publications

Capicua regulates follicle cell fate in theDrosophilaovary through repression ofmirror

Capicua regulates follicle cell fate in theDrosophilaovary through repression ofmirror

Gene regulation during Drosophila eggshell patterning

Expression of 18‐wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila

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