Juxtaglomerular cell tumor of the kidney—a new classification scheme

Dong, Dexin; Li, Hanzhong; Yan, Weigang; Xu, Weifeng

doi:10.1016/j.urolonc.2009.08.003

Cited by 37 publications

(31 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Small reninomas may be difficult to see, however, and non-renin-secreting lesions may also be observed and be suspected of being reninomas [10]. Notably in this small series, CT failed to detect the tumour in 2 patients before and 1 patient after contrast, and also reported bilateral lesions in 1 patient.…”

Section: Discussionmentioning

confidence: 87%

Reninoma: The Importance of Renal Vein Renin Ratios for Lateralisation and Diagnosis

Wolley¹,

Gordon²,

Stowasser³

2013

Am J Nephrol

View full text Add to dashboard Cite

Background/Aim: Reninomas are rare juxtaglomerular tumours which can cause severe hypertension and hypokalaemia. Diagnosis can be problematic and these tumours can be difficult to locate on imaging. In this report we aim to demonstrate the value of carefully performed renal vein renin ratios (RVRRs) to assist in locating these tumours. Method/Results: We report on 3 patients diagnosed with reninoma in our unit. The patients were all female, young (17, 16 and 30 years), severely hypertensive and hypokalaemic (2.5, 2.5 and 3.1 mmol/l). Plasma renin activity (PRA) was elevated (31.9, 274 and 175 ng/ml/h), and aldosterone was high-normal (19.9 ng/dl) or elevated (207 and 109.3 ng/dl). Renal artery stenosis was excluded by renal artery Doppler, DTPA scan and angiography. Renal CT detected the lesion in 2 patients, with one lesion visible on pre- and post-contrast CT and the other on post-contrast CT only. RVRRs were performed several weeks after withdrawing interfering medications, maintaining a <40 mmol/day low-sodium diet and maintaining recumbency overnight the night before and during the procedure. Ratios before and after captopril or enalaprilat administration were obtained and lateralised the tumours in all 3 cases (dominant/non-dominant ratios of 2.3, 4.3 and 3.8). All of the patients underwent nephrectomy yielding a typical juxtaglomerular tumour and resulting in cure of hypertension and hypokalaemia. Conclusions: Reninoma should be suspected in young hypertensives (especially females) with significant hypokalaemia and high PRA or direct renin concentration after renovascular hypertension has been excluded. CT imaging and carefully performed RVRRs provide the highest likelihood of locating these tumours.

show abstract

Section: Discussionmentioning

confidence: 87%

Reninoma: The Importance of Renal Vein Renin Ratios for Lateralisation and Diagnosis

Wolley¹,

Gordon²,

Stowasser³

2013

Am J Nephrol

View full text Add to dashboard Cite

show abstract

“…162,163 Reninoma can be divided into typical, atypical, and nonfunctioning types depending on the blood pressure and serum potassium levels. 164 Although ultrasound may in some circumstances be helpful, CT and even MRI remain the most useful imaging modalities to document the presence of a reninoma. It may appear isodense or hypodense as compared with the renal medulla 162,163 ; however, there is no definitive radiologic examination for the diagnosis of reninoma.…”

Section: Ossifying Renal Tumor Of Infancymentioning

confidence: 99%

An Approach to Renal Masses in Pediatrics

Malkan¹,

Loh²,

Bahrami³

et al. 2015

Pediatrics

View full text Add to dashboard Cite

Renal masses in children may be discovered during routine clinical examination or incidentally during the course of diagnostic or therapeutic procedures for other causes. Renal cancers are rare in the pediatric population and include a spectrum of pathologies that may challenge the clinician in choosing the optimal treatment. Correct identification of the lesion may be difficult, and the appropriate surgical procedure is paramount for lesions suspected to be malignant. The purpose of this article is to provide a comprehensive overview regarding the spectrum of renal tumors in the pediatric population, both benign and malignant, and their surgical management.

show abstract

“…The candidates of differential diagnosis are oncocytoma, epithelioid angiomyolipoma, renal cell carcinoma, and mesenchymal tumors such as glomus tumor, solitary fibrous tumor, and hemangiopericytoma. Pathological diagnosis is usually straightforward, because of characteristic clinical presentation [4]. In cases of nonfunctioning JGCT, immunohistochemistry is helpful for differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is quite difficult in cases of asymptomatic nonfunctioning JGCT [3]. Here, we present a case of nonfunctioning JGCT, which is the fourth case reported so far to the best of our knowledge [4–6]. …”

Section: Introductionmentioning

confidence: 93%

Nonfunctioning Juxtaglomerular Cell Tumor

Sakata

Shimoyamada

Yanagisawa

et al. 2013

Case Reports in Pathology

View full text Add to dashboard Cite

The juxtaglomerular cell tumor (JGCT) is a rare renal tumor characterized by excessive renin secretion causing intractable hypertension and hypokalemia. However, asymptomatic nonfunctioning JGCT is extremely rare. Here, we report a case of nonfunctioning JGCT in a 31-year-old woman. The patient presented with a left renal tumor without hypertension or hypokalemia. Under a clinical diagnosis of renal cell carcinoma, radical nephrectomy was performed. The tumor was located in the middle portion adjacent to the renal pelvis, measuring 2 cm in size. Pathologically, the tumor was composed of cuboidal cells forming a solid arrangement, immunohistochemically positive for renin. Based on these findings, the tumor was diagnosed as JGCT. In cases with hyperreninism, preoperative diagnosis of JGCT is straightforward but difficult in nonfunctioning case. Generally, JGCT presents a benign biological behavior. Therefore, we should take nonfunctioning JGCT into the differential diagnoses for renal tumors, especially in younger patients to avoid excessive surgery.

show abstract

Juxtaglomerular cell tumor of the kidney—a new classification scheme

Cited by 37 publications

References 16 publications

Reninoma: The Importance of Renal Vein Renin Ratios for Lateralisation and Diagnosis

Reninoma: The Importance of Renal Vein Renin Ratios for Lateralisation and Diagnosis

An Approach to Renal Masses in Pediatrics

Nonfunctioning Juxtaglomerular Cell Tumor

Contact Info

Product

Resources

About