Juxtaglomerular cell tumor: Clinicopathologic evaluation in a large series emphasizing its broad histologic spectrum

Abstract

The juxtaglomerular cell tumor (JCT) is a rare renal tumor. We re‐evaluated the clinicopathologic features of 21 JCTs to summarize their variable morphologies. Immunohistochemical, fluorescent in situ hybridization and periodic acid–Schiff stains were routinely performed, and four JCT cases were detected via transmission electron microscopy. The 21 JCTs involved five males and 16 females, ranging in age from 19 years to 69 years (mean, 36.9 years; median, 34 years). The tumors were composed of large, small, or spindle cells with a round, oval or polygonal shape, arranged in various growth patterns. Both necrosis (1/21) and mitosis (2/21, with 1/50HFP, 8/50HFP) was rarely appreciated. All cases were immunoreactive for renin and CD34 (21/21), and few were positive for α‐SMA (13/21;11/21, focally; 2/21, diffusely,), CD117 (9/21, focally) and synaptophysin (3/21, focally). Ultrastructurally, all four cases exhibited secretory granules in varying sizes in the cytoplasm, two of which exhibited cellular junctions. Almost all cases (20/21) had a favorable prognosis, but one succumbed due to bone and hepatic metastases, which corresponds to malignant JCT. Our study demonstrates that JCTs may have atypical clinical presentations and variable histologic appearances. A familiarity with these features may contribute to a correct diagnosis.

Juxtaglomerular cell tumor with pulmonary metastases: A case report and review of the literature

“…Pathologically, seven of eight showed either vascular invasion or mitotic figures, and among these cases, four had distant metastasis: case 1 demonstrated bilateral lung metastases 6 years after nephrectomy, 4 case 4 demonstrated bilateral lung metastases at initial diagnosis, 9 case 6 demonstrated multicentric synchronous disease in the liver and spleen, 7 and case 8 succumbed to hepatic and bone metastases 10 months after nephrectomy. 3 In our case, complete metastasectomy of the bilateral pulmonary nodules was achieved after nephrectomy.…”

“…Satoru Hamada 1,2 Tokiko Oshiro 1,2 Nobuyuki Hyakuna 1,2 Masaaki Kuda 3 Tomoro Hishiki 4 Hajime Aoyama 5 Naoto Kuroda 6 Kenji Yorita 7 Naoki Wada 8 Takako Yoshioka 9 Yuhki Koga 10 Koichi Nakanishi 1,2 1 Department of Pediatrics, University of the Ryukyus Hospital, Nishihara,…”

Juxtaglomerular cell tumor with pulmonary metastases: A case report and review of the literature

“…Pathologically, seven of eight showed either vascular invasion or mitotic figures, and among these cases, four had distant metastasis: case 1 demonstrated bilateral lung metastases 6 years after nephrectomy, 4 case 4 demonstrated bilateral lung metastases at initial diagnosis, 9 case 6 demonstrated multicentric synchronous disease in the liver and spleen, 7 case 8 succumbed to hepatic and bone metastases 10 months after nephrectomy. 3 In our case, complete metastasectomy of the bilateral pulmonary nodules was achieved after nephrectomy. Thus, he was in remission at 2 years without adjuvant chemotherapy.…”

“…In addition, CD34, CD117, vimentin, and ACTA2 are often positive. 2,3 Although JGT is generally considered benign, eight malignant or pathologically atypical cases have been reported in the literature (Table ). [3][4][5][6][7][8][9][10] Six were adult cases, and one was a pediatric case.…”

“…2,3 Although JGT is generally considered benign, eight malignant or pathologically atypical cases have been reported in the literature (Table ). [3][4][5][6][7][8][9][10] Six were adult cases, and one was a pediatric case. In all cases, the tumor diameter was relatively large (>5 cm).…”