Juxtafoveal Choroidal Neovascularization Associated with Retinitis Pigmentosa Treated with Intravitreal Bevacizumab

Parodi, Maurizio Battaglia; Benedetto, Umberto De; Knutsson, Karl Anders; Scotti, Fabrizio; Librando, Aloisa; Bandello, Francesco; Iacono, Pierluigi

doi:10.1089/jop.2011.0140

Cited by 25 publications

(28 citation statements)

References 3 publications

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“…Choroidal neovascular membrane is very rarely associated with RP. To our knowledge, only 8 cases of CNV have been described in the literature [123456]. Seven of them were type 2 CNV, 5 had a subfoveal location, and 2 a juxtafoveal location.…”

Section: Discussionmentioning

confidence: 99%

“…One case of RP with retinal angiomatous proliferation confirmed by indocyanine green angiogram has been reported in a 60-year-old woman [6]. Based on CNV therapies available at the time of their occurrence, CNVs complicating RP have been treated with laser photocoagulation [1], photodynamic therapy [3], and medical therapy [4, 5]. Intravitreal bevacizumab has been reported to be effective for choroidal neovascular membrane stabilization in patients with RP.…”

Section: Discussionmentioning

confidence: 99%

“…Retinitis pigmentosa (RP) has rarely been associated with choroidal neovascularization (CNV) [123456]. Furthermore, its association with type 3 neovascularization is even exceptional, and only 1 case of RP associated with type 3 neovascularization has been reported to date [6].…”

Section: Introductionmentioning

confidence: 99%

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Type 3 Neovascularization Associated with Retinitis Pigmentosa

Sayadi¹,

Mière²,

Souied³

et al. 2017

Case Rep Ophthalmol

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Purpose: To report a case of type 3 neovascular lesion in a patient with retinitis pigmentosa (RP) complicated by macular edema. Case Report: A 78-year-old man with a long follow-up for RP was referred for painless visual acuity decrease in the right eye. Best-corrected visual acuity was 20/125 in the right eye and 20/40 in the left. Fundus examination showed typical RP and macular edema in both eyes. In the right eye, spectral domain optical coherence tomography revealed a marked cystic macular edema associated with disruption of the Bruch membrane/retinal pigment epithelium complex overlying a pigmentary epithelium detachment, with a vascular structure which appeared to originate from the deep capillary plexus and to be connected with the subretinal pigment epithelium space. Optical coherence tomography angiography showed a high-flow vessel infiltrating the outer retinal layers in the deep capillary plexus segmentation, and a tuft-shaped, bright, high-flow network that seemed to be connected with the subretinal pigment epithelium space in the outer retinal layer segmentation. This presentation was consistent with an early type 3 neovascular lesion in the right eye. Conclusion: Type 3 neovascularization may be considered a possible complication of RP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Type 3 Neovascularization Associated with Retinitis Pigmentosa

Sayadi¹,

Mière²,

Souied³

et al. 2017

Case Rep Ophthalmol

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“…CNV - confirmed by fluorescein angiography examination - was evident in 1.7% of RP eyes. The association of RP with CNV is even rarer than other dystrophies, and only 5 cases have been reported to date [31,32,33,34]. Retinal pigment epithelium changes and concomitant photoreceptor cell involvement seem to be regularly present in RP, often being associated with choriocapillaris damage [31,32,33].…”

Section: Discussionmentioning

confidence: 99%

Spectral Domain Optical Coherence Tomography Findings in Patients with Retinitis Pigmentosa

Triolo¹,

Pierro²,

Parodi³

et al. 2013

Ophthalmic Res

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Background: To report the morphological macular findings detected by spectral domain optical coherence tomography (SD-OCT) and to determine their prevalence in patients with retinitis pigmentosa (RP). Methods: SD-OCT scans of 176 eyes from 90 patients affected by RP were reviewed. A careful evaluation was carried out on photoreceptor inner/outer segment (IS/OS) junction, external limiting membrane (ELM), inner limiting membrane thickening (ILMT), epiretinal membranes (ERMs), retinal micropseudocysts (MPCs), cystoid macular edema (CME), macular holes (MHs) and choroidal neovascularization (CNV). Results: The photoreceptor IS/OS junction was absent in the foveal region of 24 eyes (13.6%) and disrupted in 84 eyes (47.7%). The ELM was absent in 24 eyes (13.6%), whereas the ILMT was found in 118 eyes (67%). The presence of an ERM was detected in 48 eyes (27.3%). Some sort of vitreomacular alteration (ILMT and/or ERM) was identifiable in a total of 94.3% of eyes with RP. The presence of MPCs was detected in 32 eyes (18.2%). An evident CME was found in 22 eyes (12.5%). We also found MHs in 8 eyes (4.5%) and CNV in 3 eyes (1.7%). Conclusions: Our data indicate that RP is associated with alterations of many retinal layers. In particular, the vitreoretinal interface is affected in 94% of patients, and MPC can be identified in 18% of eyes. SD-OCT may contribute to the understanding of the pathophysiological mechanism involved in RP.

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“…Choroidal neovascular membranes can influence the central vision in patients with retinal dystrophies [3–8]. Management of those cases involves the use of intravitreal anti-VEGF injections.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of Choroidal Neovascularization in a Patient with Pattern Dystrophy

Anastasakis

Goleni

Livir-Rallatos

et al. 2016

Case Reports in Ophthalmological Medicine

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Purpose. To present a case of a patient with pattern dystrophy (PD) associated choroidal neovascularization (CNV) that resolved spontaneously without treatment. Methods. A 69-year-old male patient was referred to our unit, for evaluation of a recent visual loss (metamorphopsias) in his left eye. Fundus examination, fundus autofluorescence imaging, and fluorescein angiography showed a choroidal neovascular membrane in his left eye. Since visual acuity was satisfactory the patient elected observation. Clinical examination and OCT testing were repeated at 6 and 12 months after presentation. Results. Visual acuity remained stable at the level of 0.9 (baseline BCVA) during the follow-up period (12 months). Repeat OCT testing showed complete spontaneous regression of the choroidal neovascular membrane without evidence of intra- or subretinal fluid in both follow-up visits. Conclusions. Spontaneous regression of choroidal neovascularization can occur in patients with retinal dystrophies and associated choroidal neovascular membranes. The decision to treat or observe these patients relies strongly on the presenting visual acuity, since, in isolated instances, spontaneous resolution of choroidal neovascularization may occur.

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Juxtafoveal Choroidal Neovascularization Associated with Retinitis Pigmentosa Treated with Intravitreal Bevacizumab

Abstract: Intravitreal bevacizumab is effective in producing juxtafoveal CNV stabilization and visual acuity improvement in a patient affected by RP, over a 12-month follow-up. Future studies are required to ascertain the best therapeutic approach for CNV complicating RP.

Cited by 25 publications

References 3 publications

Type 3 Neovascularization Associated with Retinitis Pigmentosa

Type 3 Neovascularization Associated with Retinitis Pigmentosa

Spectral Domain Optical Coherence Tomography Findings in Patients with Retinitis Pigmentosa

Spontaneous Regression of Choroidal Neovascularization in a Patient with Pattern Dystrophy

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