Juvenile xanthogranuloma of the nose in an adult

Gedela, VR; Roy, Debajyoti; Swift, A. C.

doi:10.12968/hosp.2002.63.9.1958

Cited by 4 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,3,4,5 Gedela et al and Tan et al reported AXG of nasal columella and nasal ala respectively. 2,6 Similar to our case, these patients presented with slow-growing nasal nodule without any history of nasal obstruction or similar lesion elsewhere. Worden et al described AXG involving the pyriform aperture of the nose in a 73-year-old lady who presented with nasal obstruction.…”

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Xanthogranuloma of nose in an adult: an uncommon presentation

Palo

Barsagade

Sikdar

2021

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

<p class="abstract">Xanthogranuloma is a relatively rare histiocytic cutaneous disorder that typically affects the pediatric age group. Its occurrence in adulthood is still rarer with only a handful of cases on the record. The present case report describes a case of adult-onset xanthogranuloma in a 49 years old lady who presented to the otorhinolaryngology clinic with a 6 months history of a nodule on the left side of the columella. There was no history of associated pain or bleeding from the site. Local examination revealed a 0.6×0.6 cm, non-tender, soft-to-firm, pinkish dome-shaped lesion with rounded edges. No similar lesions were found elsewhere. Excisional biopsy of the lesion was performed and microscopy showed a dermal lesion comprising of sheets of histiocytes admixed with lymphoplasmacytic infiltrate, touton giant cells and few spindle cells. A diagnosis of xanthogranuloma was rendered. A number of lympho-histiocytic lesions comes in the differential diagnosis of xanthogranuloma and hence it is important to be aware of such unusual presentations in order to make correct histological diagnosis.</p>

show abstract

Section: Discussionsupporting

confidence: 83%

“…The giant cells are of Touton type, although foreign body type of giant cells may also be present. 2 Early lesions may lack these giant cells. 3 Immunohistochemically, the lesional histocytes are positive for CD68 and negative for S100, CD1a and CD207, thereby differentiating it from Langerhans' cell histiocytosis.…”

Section: Discussionmentioning

confidence: 99%

Xanthogranuloma of nose in an adult: an uncommon presentation

Palo

Barsagade

Sikdar

2021

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…4 The extracutaneous sites frequently involved include the eye (most common), lungs, liver, testes and pericardium, oral cavity, larynx and temporal bone. 2 Histologically, juvenile xanthogranulomas comprise of giant cells, histiocytes, and scarce acute inflammatory cells. Histiocytes, which predominate, commonly contains lipid and grow in solid sheets.…”

Section: Discussionmentioning

confidence: 99%

“…4 Strongly positive immunohistochemical analysis of xanthogranuloma is seen for Factor XIIIa, KP1, KiM1P, HAM 56, HHF 35, and vimentin, whereas S-100 protein, anti-Macrophages antibody (MAC 387), Leu M1, and desmin show a negative result. 2,7 Histiocytosis X has a close resemblance to juvenile xanthogranuloma. It is characterized by the presence of indented nuclei with invasion of the overlying epidermis seen on light microscopy.…”

Section: Discussionmentioning

confidence: 99%

Rare Xanthogranulomatous Inflammation of the Nose

Ganeson

2023

J Clin Pract Res

View full text Add to dashboard Cite

Background: Juvenile xanthogranuloma is an uncommon benign mass that frequently arises among children. Regardless of its juvenile onset, the occurrence among the adult population is usually between the second and third decades of life. Case Report: We would like to present a case of adult xanthogranuloma in a 30-year-old male and a brief literature review of its etiology, histopathology, and management. Conclusion: Juvenile xanthogranuloma is a benign disease that is common in childhood but rare in adults. The diagnosis is confirmed by histological studies. The lesion is generally self-limiting and regresses spontaneously; however, surgical excision can be performed for cosmetic or diagnostic purposes.

show abstract

“…A comprehensive review of the English-language literature revealed only 1 other case with this presentation in an adult. 1 We discuss this interesting case and present a brief review of the disease process.…”

mentioning

confidence: 99%