Juvenile Xanthogranuloma

Abstract

Juvenile xanthogranuloma, a benign, non-Langerhans histiocytic proliferation, is frequently seen in infants and children. The etiology is unknown, although it may represent a reactive process. A variety of diseases, including neurofibromatosis type 1 and juvenile chronic myelogenous leukemia, may be associated with juvenile xanthogranuloma, and patients with this combination of findings require special management. In children, approximately 5% of juvenile xanthogranulomas involve extracutaneous sites. This case review provides a detailed discussion of the clinical and pathologic features of juvenile xanthogranuloma and its differential diagnosis.

Shapiro xanthogranuloma: An essential diagnosis for dermatologists and dermatopathologists to recognize to avoid misdiagnosis of a hematopoietic malignancy in infants and neonates

“…Juvenile xanthogranuloma (JXG or simply XG) is a benign, non‐Langerhans histiocytosis that classically presents as single or multiple yellow, orange, brown, or skin‐colored nodules, most commonly on the head and neck of children 1 . Recently, XG have been classified under the “C” (“cutaneous”) group of histiocytoses by the International Histiocyte Society working group 2 .…”