Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis

Mouri, Akihiro; Ukai, Makoto; Uchida, Masahiko; Hasegawa, Sho; Taniguchi, Masayuki; Ito, Takahiro; Hida, Hirotake; Yoshimi, Akira; Yamada, Kiyofumi; Kunimoto, Shohko; Ozaki, Norio; Nabeshima, Toshitaka; Noda, Yukihiro

doi:10.1016/j.neuropharm.2018.01.016

Cited by 52 publications

(85 citation statements)

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“…Submissive posture was defined as standing upright with the belly exposed to the aggressor. The duration of defensive behaviors was recorded according to our previous report (Mouri et al, 2018). After 10 minutes, an aggressive mouse was separated from the defeated mouse to avoid habituation to the defeated mouse and placed in its group-housed home cage for the next 24 hours.…”

Section: Methodsmentioning

confidence: 99%

“…We previously found that mice exposed to a nonaggressive ICR mouse (undefeated mice) as well as an empty cage (control mice) for 10 consecutive days showed significantly increased duration at the interaction zone in the second session compared with that in the first session (Mouri et al, 2018). Thus, it is unlikely that defeated mice were habituated to expose ICR mouse during social defeat stress and did not approach familiar target ICR mouse.…”

Section: Methodsmentioning

confidence: 99%

“…The social interaction test was performed from 10:00 am to 5:00 pm in a sound-attenuated room, as described in our previous report (Mouri et al, 2018). The apparatus consisted of an open gray nonreflecting acrylic box (W42×D42×H30 cm) and the transparent Plexiglas enclosure (W10×D6.5×H30 cm) with 30 holes (10 mm in diameter).…”

Section: Methodsmentioning

confidence: 99%

“…The social interaction test consisted of 2 sessions: in the first session, the mouse was allowed to freely explore and habituate to the test environment for 30 minutes in the absence of an unfamiliar target ICR mouse, in consistent with a previous report (Mouri et al, 2018). This was done to reduce the time spent in the interaction zone by exploring the apparatus itself during the second session.…”

Section: Methodsmentioning

confidence: 99%

“…These findings suggest that brain monoaminergic neuronal systems are involved in the impairment of social behaviors induced by social defeat stress exposure. We previously found that juvenile mice were more vulnerable to the impairment of social behaviors induced by social defeat stress exposure than adult mice (Mouri et al, 2018). However, the role of monoaminergic neuronal systems in the impairment of social behaviors induced by social defeat stress exposure as juveniles remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Dysfunction of Serotonergic and Dopaminergic Neuronal Systems in the Antidepressant-Resistant Impairment of Social Behaviors Induced by Social Defeat Stress Exposure as Juveniles

Hasegawa

Miyake

Yoshimi

et al. 2018

International Journal of Neuropsychopharmacology

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BackgroundExtensive studies have been performed on the role of monoaminergic neuronal systems in rodents exposed to social defeat stress as adults. In the present study, we investigated the role of monoaminergic neuronal systems in the impairment of social behaviors induced by social defeat stress exposure as juveniles.MethodsJuvenile, male C57BL/6J mice were exposed to social defeat stress for 10 consecutive days. From 1 day after the last stress exposure, desipramine, sertraline, and aripiprazole were administered for 15 days. Social behaviors were assessed at 1 and 15 days after the last stress exposure. Monoamine turnover was determined in specific regions of the brain in the mice exposed to the stress.ResultsStress exposure as juveniles induced the impairment of social behaviors in adolescent mice. In mice that showed impairment of social behaviors, turnover of serotonin and dopamine, but not noradrenaline, was decreased in specific brain regions. Acute and repeated administration of desipramine, sertraline, and aripiprazole failed to attenuate the impairment of social behaviors, whereas repeated administration of a combination of sertraline and aripiprazole showed additive attenuating effects.ConclusionsThese findings suggest that social defeat stress exposure as juveniles induces the treatment-resistant impairment of social behaviors in adolescents through dysfunction in the serotonergic and dopaminergic neuronal systems. The combination of sertraline and aripiprazole may be used as a new treatment strategy for treatment-resistant stress-related psychiatric disorders in adolescents with adverse juvenile experiences.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dysfunction of Serotonergic and Dopaminergic Neuronal Systems in the Antidepressant-Resistant Impairment of Social Behaviors Induced by Social Defeat Stress Exposure as Juveniles

Hasegawa

Miyake

Yoshimi

et al. 2018

International Journal of Neuropsychopharmacology

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Molecular and neurocircuitry mechanisms of social avoidance

Gellner

Voelter

Schmidt

et al. 2020

Cell. Mol. Life Sci.

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Humans and animals live in social relationships shaped by actions of approach and avoidance. Both are crucial for normal physical and mental development, survival, and well-being. Active withdrawal from social interaction is often induced by the perception of threat or unpleasant social experience and relies on adaptive mechanisms within neuronal networks associated with social behavior. In case of confrontation with overly strong or persistent stressors and/or dispositions of the affected individual, maladaptive processes in the neuronal circuitries and its associated transmitters and modulators lead to pathological social avoidance. This review focuses on active, fear-driven social avoidance, affected circuits within the mesocorticolimbic system and associated regions and a selection of molecular modulators that promise translational potential. A comprehensive review of human research in this field is followed by a reflection on animal studies that offer a broader and often more detailed range of analytical methodologies. Finally, we take a critical look at challenges that could be addressed in future translational research on fear-driven social avoidance.

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Features of the Social Behavior of Mice after Prolonged Exposure to Psychoemotional and Infective Factors

Августинович

Bondar

2021

Neurosci Behav Physi

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Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis

Cited by 52 publications

References 53 publications

Dysfunction of Serotonergic and Dopaminergic Neuronal Systems in the Antidepressant-Resistant Impairment of Social Behaviors Induced by Social Defeat Stress Exposure as Juveniles

Dysfunction of Serotonergic and Dopaminergic Neuronal Systems in the Antidepressant-Resistant Impairment of Social Behaviors Induced by Social Defeat Stress Exposure as Juveniles

Molecular and neurocircuitry mechanisms of social avoidance

Features of the Social Behavior of Mice after Prolonged Exposure to Psychoemotional and Infective Factors

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