Juvenile rheumatoid arthritis of the knee: evaluation with contrast-enhanced color Doppler ultrasound

Doria, A.; Kiss, Mária; Lotito, Ana Paola N.; Molnar, Laszlo J.; Castro, Cláudio Campi de; Medeiros, Carmen; Cerri, Giovanni Guido

doi:10.1007/s002470100474

Cited by 84 publications

(48 citation statements)

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“…They hold potential for detecting changes of low-volume, low-velocity blood flow in small vessels such as those of the synovium in arthritic joints [51].…”

Section: Microbubble Contrast-enhanced Ultrasonographymentioning

confidence: 99%

State‐of‐the‐art imaging techniques for the evaluation of haemophilic arthropathy: present and future

Doria

2010

Haemophilia

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103

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Summary. In spite of the fact that the diagnosis of haemophilia is essentially clinical and laboratorybased, imaging has become an important tool for the evaluation of complications, diagnostic confirmation and/or complementation and therapeutic follow-up in haemophilic arthropathy. Radiography remains the workforce horse in the diagnosis and follow-up of haemophilic arthropathy. The radiographical findings in arthropathy follow an expected sequence of events and are overall similar in different joints. Magnetic resonance imaging (MRI) has advantages over radiography based on its capability of visualizing soft tissue and cartilage changes in haemophilic joints. The recent development and standardization of MRI scoring systems for measuring soft tissue and cartilage abnormalities may enable the comparison of pathological joint findings in clinical trials conducted at different institutions across the world. The implementation of high-frequency transducers and colour/power Doppler capabilities has provided new insights for clinical applications of ultrasonography (US) in haemophilic arthropathy. In spite of the imaging modality's technical challenges such as operator-dependency, US has advantages over MRI. One of these advantages is its ability of differentiating synovium hypertrophy and hemosiderin deposition, which is not possible with MRI given the presence of susceptibility artefacts from extracellular hemosiderin on gradient-echo MR images. In addition to the aforementioned conventional imaging modalities, novel imaging techniques (blood oxygen level dependent, ultrasmall superparamagnetic ironoxide contrast-enhanced, and T1 and T2 mapping MRI, ultrasound biomicroscopy, microbubble contrast-enhanced US and positron emission tomography, among others) hold promise for early assessment of haemophilic arthropathy in the future upon completion of their clinical validation.

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“…They hold potential for detecting changes of low-volume, low-velocity blood flow in small vessels such as those of the synovium in arthritic joints [51].…”

Section: Microbubble Contrast-enhanced Ultrasonographymentioning

confidence: 99%

State‐of‐the‐art imaging techniques for the evaluation of haemophilic arthropathy: present and future

Doria

2010

Haemophilia

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103

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“…Based on their researches on knee joint lesions of RA patients, Schmidt et al [22,23] found that the contrast-enhanced ultrasound could show blood perfusion of the synovium. Through the researches on adolescent RA, Doria et al [12,24] found that the ultrasound contrast can be applied to distinguish between active and non-active synovitis and to assess efficacy of treatment. The blood supply will be reduced after treatment.…”

Section: Discussionmentioning

confidence: 99%

Antigen-induced arthritis in rabbits: a comparative study between high-resolution ultrasound and contrast-enhanced ultrasound and pathologic findings

et al. 2011

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The objective of this study was to explore the feasibility and value of high-resolution ultrasound and contrast-enhanced ultrasound in evaluation of synovitis in rabbit knee joint in antigen-induced arthritis (AIA). Thirty-six rabbits were divided into three groups, each injected with different doses of ovalbumin (OVA) into the right knee joint. On week 1 and 4, 6 randomly selected in each group were killed. Each knee joint undergone the high-resolution ultrasound to measure capsule thickness and contrast-enhanced ultrasound to measure synovium thickness. The results from the ultrasound examinations were compared with those of pathologic examinations. Different OVA doses resulted in different modeling success rate, different pathological synovitis score, and different capsule and synovium thickness measured by ultrasound. The diagnostic accuracy of synovitis by ultrasound was high. The ultrasound measurement revealed that the capsule thickness on week 4 was lessened than that on week 1, while the synovial thickness on week 4 was greater than that on week 1. Both the joint capsule and synovium thickness measured by ultrasound were significantly and positively correlated to the pathologic synovitis score (P < 0.05). The synovial thickness on week 4 is more correlated to the synovitis score than the capsule thickness, rather than that on week 1. Injection of OVA of different doses results in different modeling success rate and synovitis severity. The high-resolution ultrasound and contrast-enhanced ultrasound can be used to determine whether the AIA was made successfully and evaluate the synovitis severity. In chronic inflammatory phase, the contrast-enhanced ultrasound has better effect.

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“…The ability of MRI and ultrasound to detect early, often subclinical disease by directly visualizing synovial inflammation is an advantage with regards to the prompt initiation of disease treatment [2,[9][10][11]. Both CT and fluoroscopy can also be used to guide for therapeutic interventions, as well as diagnostic procedures, such as myelography, providing additional dynamic and functional information.…”

Section: Discussionmentioning

confidence: 99%

Imaging of Juvenile Rheumatoid Arthritis

Sofka

Bogner

2008

HSS Journal®

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Juvenile rheumatoid arthritis of the knee: evaluation with contrast-enhanced color Doppler ultrasound

Abstract: Contrast-enhanced color Doppler imaging holds promise for the detection of active synovial inflammatory disease in subclinical cases of JRA, thereby allowing earlier treatment and improved clinical outcome.

Cited by 84 publications

References 0 publications

State‐of‐the‐art imaging techniques for the evaluation of haemophilic arthropathy: present and future

State‐of‐the‐art imaging techniques for the evaluation of haemophilic arthropathy: present and future

Antigen-induced arthritis in rabbits: a comparative study between high-resolution ultrasound and contrast-enhanced ultrasound and pathologic findings

Imaging of Juvenile Rheumatoid Arthritis

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