Juvenile onset systemic lupus erythematosus thyroid dysfunction: A subgroup with mild disease?

Costa, Luciana Parente; Bonfá, Eloísa; Martinago, Cikro D.; Oliveira, Ricardo Manoel de; Carvalho, Jozélio Freire de; Pereira, Rosa Maria Rodrigues

doi:10.1016/j.jaut.2009.04.001

Cited by 15 publications

(9 citation statements)

References 33 publications

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“…Till now there is no available studies explain the association between increasing the SLE disease activity scores and increasing the thyroid antibodies. Our data agrees with Parente et al 23 , who found that higher levels of thyroid antibodies as well as hypothyroid function tests in his SLE schoolchildren patients with higher disease activity assessed by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI).…”

Section: Discussionsupporting

confidence: 93%

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Thyroid Dysfunction in Patients with Systemic Lupus Erythematosus, Correlation with Disease Activity

Salama

Mohsen

Mohammed

et al. 2014

Egypt J of Rheumatol & Clinical Immunol

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Background: The relationship between autoimmune thyroid disease and systemic lupus erythematosus (SLE) has been revealed but the prevalence of thyroid disease in lupus patients is controversial. The aim of this study is to assess thyroid dysfunction and the presence of anti-thyroid antibodies in patients with SLE, and its association with disease characteristics and disease activity. Methods: Sixty patients with SLE ≥ 18 years who satisfied the American College of Rheumatology (ACR) criteria and thirty age and sex matched normal volunteer were included, all underwent laboratory evaluation for serum free T3, free T4, TSH, Antithyroglobulin antibody (Ab TG) and Antithyroid peroxidase antibody (Ab TPO). Clinical and serological characteristics and disease activity of SLE were assessed; correlation with thyroid dysfunction was studied. Results: 2(3.33%) patients had subclinical hyperthyroidism, 24 (40%) were euthyroid, 12 (21.67%) had subclinical hypothyroidism and 22 (35%) had overt hypothyroidism. All the control group was euthyroid. The patients with thyroid dysfunction had more arthralgias, arthritis, changes of voice, bowel habits and weight, irregular menstruation, sleep disturbance, nervousness and tremors than the euthyroid lupus patients (p<0.05). The lupus patients with subclinical and overt hypothyroidism had statistically significant higher Ab TG than the euthyroid patients and patients with subclinical hyperthyroidism and control group (p<0.05) but no statistically significant difference between all groups as regard Ab TPO. SLE patients with subclinical & overt hypothyroidism had statistically significant higher ESR and SLAM score than the euthyroid patients and patients with subclinical hyperthyroidism (p<0.05). There was a positive correlation between Ab TG levels and body mass index BMI, ESR and disease activity measures by SLAM score (p<0.05). Conclusion: The thyroid dysfunction is more frequent in SLE patients than control group. Subclinical and overt hypothyroidism are more likely to occur in SLE patients. There are a positive correlation between Ab TG level and disease activity and negative correlation with free T3 & free T4.

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Section: Discussionsupporting

confidence: 93%

“…Also Weetman & Walport 9 , Vianna et al 16 and Park et al 22 studies also reported that thyroid dysfunction more common in older age. But, Parente et al study 23 had found that in SLE schoolchildren patients had higher hypothyroid function tests.…”

Section: Discussionmentioning

confidence: 91%

Thyroid Dysfunction in Patients with Systemic Lupus Erythematosus, Correlation with Disease Activity

Salama

Mohsen

Mohammed

et al. 2014

Egypt J of Rheumatol & Clinical Immunol

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“…In addition to the use of immune system TSHβv in response to infection and for bone remodeling, a number of human conditions tied to thyroid dysregulation, many of which are associated with inflammation or autoimmunity, have yet to be fully understood. These include Graves' disease and Hashimoto's thyroiditis (64–66), Graves' Ophthalmopathy (67, 68), Pendred's Syndrome (69), Lyme disease (70), inflammatory bowel disease (71), rheumatoid arthritis (72), systemic lupus erythematosus (73, 74), psoriasis (75), asthma (76), and sepsis (77, 78). Of particular interest, patients with Hashimoto's thyroiditis (HT) were found to have elevated transcript levels of TSHβv in PB compared to normal controls (24).…”

Section: The Tshβ Splice Variant (Tshβv)mentioning

confidence: 99%

Novel Splicing of Immune System Thyroid Stimulating Hormone β-Subunit—Genetic Regulation and Biological Importance

Klein

2019

Front. Endocrinol.

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Thyroid stimulating hormone (TSH), a glycoprotein hormone produced by the anterior pituitary, controls the production of thyroxine (T4) and triiodothyronine (T3) in the thyroid. TSH is also known to be produced by the cells of the immune system; however, the physiological importance of that to the organism is unclear. We identified an alternatively-spliced form of TSHβ that is present in both humans and mice. The TSHβ splice variant (TSHβv), although produced at low levels by the pituitary, is the primary form made by hematopoietic cells in the bone marrow, and by peripheral leukocytes. Recent studies have linked TSHβv functionally to a number of health-related conditions, including enhanced host responses to infection and protection against osteoporosis. However, TSHβv also has been associated with autoimmune thyroiditis in humans. Yet to be identified is the process by which the TSHβv isoform is produced. Here, a set of genetic steps is laid out through which human TSHβv is generated using splicing events that result in a novel transcript in which exon 2 is deleted, exon 3 is retained, and the 3′ end of intron 2 codes for a signal peptide of the TSHβv polypeptide.

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“…These include Graves’ disease and Hashimoto’s thyroiditis (22), Graves’ ophthalmopathy (23, 24), Pendred’s syndrome (25), Lyme disease (26), inflammatory bowel disease (27), rheumatoid arthritis (28), systemic lupus erythematosus (29, 30), psoriasis (31), asthma (32), sepsis (33, 34), and hypothyroidism that may accompany type I interferon therapy (35–37). …”

Section: Role Of the Tshβv In Health And Diseasementioning

confidence: 99%

Biological Impact of the TSHÎ² Splice Variant in Health and Disease

Klein

2014

Front. Immunol.

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Thyroid stimulating hormone (TSH), a glycoprotein hormone composed of α and β chains, is produced by thyrotrope cells of the anterior pituitary. Within the conventional endocrine loop, pituitary-derived TSH binds to receptors in the thyroid, resulting in the release of the thyroid hormones thyroxine (T4) and triiodothyronine (T3). T4 and T3 in turn regulate nearly every aspect of mammalian physiology, including basal metabolism, growth and development, and mood and cognition. Although TSHβ has been known for years to be produced by cells of the immune system, the significance of that has remained largely unclear. Recently, a splice variant of TSHβ (TSHβv), which consists of a truncated but biologically functional portion of the native form of TSHβ, was shown to be produced by bone marrow cells and peripheral blood leukocytes, particularly cells of the myeloid/monocyte lineage. In contrast, full-length native TSHβ is minimally produced by cells of the immune system. The present article will describe the discovery of the TSHβv and will discuss its potential role in immunity and autoimmunity, inflammation, and bone remodeling.

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Juvenile onset systemic lupus erythematosus thyroid dysfunction: A subgroup with mild disease?

Cited by 15 publications

References 33 publications

Thyroid Dysfunction in Patients with Systemic Lupus Erythematosus, Correlation with Disease Activity

Thyroid Dysfunction in Patients with Systemic Lupus Erythematosus, Correlation with Disease Activity

Novel Splicing of Immune System Thyroid Stimulating Hormone β-Subunit—Genetic Regulation and Biological Importance

Biological Impact of the TSHÎ² Splice Variant in Health and Disease

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