Juvenile nasopharyngeal angiofibroma

Singh, Rohan Kumar; Lakhkar, Bhushita; Patwa, Prerna; Mishra, Gaurav Vedprakash

doi:10.1136/bcr-2021-248023

Cited by 3 publications

(6 citation statements)

References 2 publications

(3 reference statements)

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“…Finally, 33 articles with 41 cases describing 44 lesions met the selection criteria for the systematic review (Figure 1). 10,26–57 With 13 additional cases from our institution (Table 1), the final study cohort comprised 54 cases with 57 lesions associated with STAs.…”

Section: Resultsmentioning

confidence: 99%

MRI features of sinonasal tract angiofibroma/juvenile nasopharyngeal angiofibroma: Case series and systematic review

Baba

Kurokawa

et al. 2023

Journal of Neuroimaging

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Background and PurposeTo comprehensively summarize the radiological characteristics of sinonasal tract angiofibroma (STA) (commonly known as juvenile nasopharyngeal angiofibroma).MethodsForty‐four lesions from 41 cases provided by 33 study articles identified through a systematic review and 13 lesions from 13 cases from our institution associated with patients with STA who underwent MRI were included in the review study, carried out by two board‐certified experienced radiologists.ResultsThe study participants were all male patients with a mean age of 15.6 years at the time of diagnosis. All of them presented with nasal cavity lesions (100%), predominantly in the nasopharynx (98.2%). The sphenopalatine foramen/pterygopalatine fossa was involved in 76.0%, and compressive shift of the posterolateral wall of the maxillary sinus was present in more than half (57.9%). T2‐weighted imaging signal intensity was heterogeneous with mixed high and iso intensities as compared to skeletal muscle (100%). T1‐weighted imaging showed partial high signal intensity in 61.1% of the cases. Flow void and intense enhancement were present in almost all cases. Cystic/nonenhancement changes on contrast‐enhanced MRI were relatively common (40.8%). The mean apparent diffusion coefficient value (2.07 × 10−3 mm2/second) and some quantitative dynamic contrast‐enhanced MRI parameters were high. There was a significant difference in the frequency of residual/recurrent lesions based on the presence of MRI findings of skull base invasion (p = .017) and intracranial extension (p = .003).ConclusionsWe summarized the MRI findings of STA that can facilitate timely diagnosis and appropriate management.

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Section: Resultsmentioning

confidence: 99%

MRI features of sinonasal tract angiofibroma/juvenile nasopharyngeal angiofibroma: Case series and systematic review

Baba

Kurokawa

et al. 2023

Journal of Neuroimaging

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“…The gold-standard treatment for JNA is surgical excision of the tumor, 2,7,11,[15][16][17]48 which includes external approaches, such as the transpalatine approach, medial maxillectomy (degloving or lateral rhinotomy), maxillary swing, Le Fort osteotomy, infratemporal fossa approach, and endoscopic techniques. 1,2,5,7,11,14,17,44,48,49 The choice of the approach should be based on the stage, site, extension of the lesion, and surgery experience.…”

Section: Discussionmentioning

confidence: 99%

“…12 Surgery is currently considered the treatment of choice for JNA. [2][3][4]7,8,[11][12][13][14][15][16][17] Although some studies 8,18 mention the use of adjuvant radiotherapy for unresectable tumors, failure to remove the tumor completely, or extensive intracranial extension, its use is controversial. Chemotherapy, hormonal therapy, and, more recently, gamma knife radiosurgery in conjunction with surgical resection have been occasionally proposed, although with limited experience 18,19 and controversial efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…7,9 Preoperative embolization is used in most surgical procedures due to the vascular nature of the tumor, and it is considered an acceptable means of decreasing intraoperative blood loss. 1,6,12,13,15,16,20,21 The present study intends to describe the experience with a series of 96 JNA cases treated in one institution: Instituto Felippu de Otorrinolaringologia (IFO), in São Paulo, Brazil.…”

Section: Introductionmentioning

confidence: 99%

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Juvenile Nasopharyngeal Angiofibroma: A Series of 96 Surgical Cases

Felippu,

Fontes,

Felippu

et al. 2024

Int Arch Otorhinolaryngol

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Introduction Juvenile nasopharyngeal angiofibroma (JNA) is a benign vascularized tumor that affects almost exclusively male adolescents. Surgery is the treatment of choice for JNA. Objectives The present study is a 42-year retrospective review of a series of JNA cases treated surgically without previous embolization. Methods The present is a retrospective, descriptive study based on medical records of 96 patients with JNA who underwent microscopic or endoscopic excision without previous embolization from 1978 to 2020 in a single institution. The patients were categorized according to the Andrews et al. stage, and data were collected on age, gender, tumor staging, surgical approach, affected side, and outcome. Results All patients were male, with an average age of 17 years. The predominant tumor stage consisted of type II, with 52.1%. A total of 33.3% of the patients were submitted to the microscopic technique and 66.7%, to the endonasal technique. The rate of intraoperative blood transfusion was of 17.7%. Conclusion The present study reinforces that resection of JNA in various stages is viable without previous artery embolization.

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“…The Juvenile Nasopharyngeal Angiofibroma (JNA) is a benign tumour whose main origin is in the posterior part of the nasal cavity. It is a vascular lesion frequently derived from the internal maxillary and ascending pharyngeal artery; the growth of these lesions tends to erode bony structures at the base of the skull, with the capacity to extend towards the nose, paranasal sinuses, orbit and intracranial region [1]. It has an incidence of 0.05% -0.5% and it is most frequently found in males between 10 and 25 years of age [2].…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Conformal and Intensity Modulated Dynamic Radiotherapy in Juvenile Nasopharyngeal Angiofibroma

Chilaca-Rosas,

Salazar-Calderon,

Contreras-Aguilar

et al. 2023

IJOHNS

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Objective: Juvenile Nasopharyngeal Angiofibroma (JNA) is a benign neoplasm with a high vascularity component, greater craniofacial involvement in adolescent patients, and aggressive local behaviour. In unresectable patients, radiotherapy is a therapeutic option for local control. Our aim in this study was to analyze the clinical benefit and local control provided by two modalities of radiotherapy: the Three-Dimensional Conformal (3DC) technique and volumetric modulated arc therapy (VMAT), applied to pediatric patients with JNA considered unresectable and non-recurrent. Methods: In retrospective study, the information was recorded from pediatric patients with a diagnosis of non-recurrent and unresectable JNA treated with radiotherapy at the Oncology Hospital of the National Medical Center SXXI of Mexico City, from March 2010 to March 2021. Radiotherapy management and its association with clinical outcomes of tumour control, and symptoms were assessed. In addition, an evaluation of acute and chronic toxicity was performed. Results: It was found that the median age was 14 years. 9 patients (37.5%) underwent 3DC and 15 (62.5%) VMAT. In terms of local control, and progression-free survival, we did not find significant difference between radiotherapy modalities (p ≤ 0.57). Acute toxicity for both modalities presented statistical differences for radio epithelitis (p = 0.03). Only Grade I and II radiation-induced acute toxicity was observed. Regarding chronic toxicity, statistical significance was observed for craniofacial hypoplasia,

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Juvenile nasopharyngeal angiofibroma

Cited by 3 publications

References 2 publications

MRI features of sinonasal tract angiofibroma/juvenile nasopharyngeal angiofibroma: Case series and systematic review

MRI features of sinonasal tract angiofibroma/juvenile nasopharyngeal angiofibroma: Case series and systematic review

Juvenile Nasopharyngeal Angiofibroma: A Series of 96 Surgical Cases

Three-Dimensional Conformal and Intensity Modulated Dynamic Radiotherapy in Juvenile Nasopharyngeal Angiofibroma

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