Juvenile Myoclonic Epilepsy: A Study in Saudi Arabia

Obeid, Tahir; Panayiotopoulos, C. P.

doi:10.1111/j.1528-1157.1988.tb03718.x

Cited by 101 publications

(69 citation statements)

References 6 publications

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“…Lancman et al (7) described unilateral polyspike and wave in 7 of 85 patients with JME and asymmetrical polyspike and wave discharges in an additional 7 patients. Focal interictal spikes are also well described in JME (6).…”

Section: Discussionmentioning

confidence: 87%

Idiopathic Generalized Epilepsy Presenting With Hemiconvulsive Seizures

2000

Epilepsia

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Section: Discussionmentioning

confidence: 87%

Idiopathic Generalized Epilepsy Presenting With Hemiconvulsive Seizures

2000

Epilepsia

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“…Idiopathic generalized epilepsies, now called genetic generalized epilepsies (Berg et al. 2010) comprise at least 40% of these epilepsies in the USA and 8% in Central America, including Honduras (Obeid and Panayiotopoulos 1988; Jallon 1997; Nicoletti et al. 1999; Medina et al.…”

Section: Introductionmentioning

confidence: 99%

Chromosome loci vary by juvenile myoclonic epilepsy subsyndromes: linkage and haplotype analysis applied to epilepsy and EEG 3.5–6.0 Hz polyspike waves

Wight

Nguyen

Medina³

et al. 2016

Molec Gen & Gen Med

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Juvenile myoclonic epilepsy (JME), the most common genetic epilepsy, remains enigmatic because it is considered one disease instead of several diseases. We ascertained three large multigenerational/multiplex JME pedigrees from Honduras with differing JME subsyndromes, including Childhood Absence Epilepsy evolving to JME (CAE/JME; pedigree 1), JME with adolescent onset pyknoleptic absence (JME/pA; pedigree 2), and classic JME (cJME; pedigree 3). All phenotypes were validated, including symptomatic persons with various epilepsies, asymptomatic persons with EEG 3.5–6.0 Hz polyspike waves, and asymptomatic persons with normal EEGs. Two‐point parametric linkage analyses were performed with 5185 single‐nucleotide polymorphisms on individual pedigrees and pooled pedigrees using four diagnostic models based on epilepsy/EEG diagnoses. Haplotype analyses of the entire genome were also performed for each individual. In pedigree 1, haplotyping identified a 34 cM region in 2q21.2–q31.1 cosegregating with all affected members, an area close to 2q14.3 identified by linkage (Z max = 1.77; pedigree 1). In pedigree 2, linkage and haplotyping identified a 44 cM cosegregating region in 13q13.3–q31.2 (Z max = 3.50 at 13q31.1; pooled pedigrees). In pedigree 3, haplotyping identified a 6 cM cosegregating region in 17q12. Possible cosegregation was also identified in 13q14.2 and 1q32 in pedigree 3, although this could not be definitively confirmed due to the presence of uninformative markers in key individuals. Differing chromosome regions identified in specific JME subsyndromes may contain separate JME disease‐causing genes, favoring the concept of JME as several distinct diseases. Whole‐exome sequencing will likely identify a CAE/JME gene in 2q21.2–2q31.1, a JME/pA gene in 13q13.3–q31.2, and a cJME gene in 17q12.

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“…Approximately 3% of children and 11% of adolescents and adults with seizures fit the criteria for a diagnosis of juvenile myodonic epilepsy (10,14). Most patients are between the ages of 12 and 18 years at the time of onset, but the condition may persist throughout adulthood.…”

Section: Epilepsy Syndromesmentioning

confidence: 99%

Advances in pharmacotherapy: recent developments in the treatment of epilepsy

Graves

Leppik

1993

J Clin Pharm Ther

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SUMMARY Epilepsy is a disorder of the central nervous system in which the clinical symptoms are recurrent seizures. An increased understanding of the underlying mechanism of seizures and more definitive diagnostic procedures have improved the care of the patient with epilepsy. An improved classification of various seizure types, including specific epilepsy syndromes has helped optimize use of the standard antiepileptic drugs. Research on the mechanism of seizures has led to new antiepileptic drugs. More definitive diagnostic procedures have led to more accurate identification of patients likely to benefit from epilepsy surgery. This review focuses on these areas.

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Juvenile Myoclonic Epilepsy: A Study in Saudi Arabia

Cited by 101 publications

References 6 publications

Idiopathic Generalized Epilepsy Presenting With Hemiconvulsive Seizures

Idiopathic Generalized Epilepsy Presenting With Hemiconvulsive Seizures

Chromosome loci vary by juvenile myoclonic epilepsy subsyndromes: linkage and haplotype analysis applied to epilepsy and EEG 3.5–6.0 Hz polyspike waves

Advances in pharmacotherapy: recent developments in the treatment of epilepsy

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