Juvenile IGF-I: An Early Bio-marker for Feed Efficiency in Pigs

Mauch, Emily; Serão, Nick V. L.; Wolc, Anna; Bunter, Kim L; Dekkers, Jack C. M.

doi:10.31274/ans_air-180814-247

Cited by 1 publication

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“…Even though fluctuations in food availability frequently occur in nature and IGF-1 might facilitate adaptations toward these conditions (O'Sullivan et al, 1989), our knowledge about the role of IGF-1 in shaping responses to such events in wild animals is limited. The majority of literature presents the findings of medical and agricultural sciences, focusing on humans and laboratory or farmed animals (Robinson et al, 2006;Berryman et al, 2008;Valente et al, 2013;Mauch et al, 2016;Rahmani et al, 2019). There are only a few examples from wild, free-living animals, such as a study in Eastern fence lizard (Sceloporus undulatus) which shows that food-restriction decreased plasma IGF-1 levels (Duncan et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Food Restriction Reveals Individual Differences in Insulin-Like Growth Factor-1 Reaction Norms

et al. 2022

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Most organisms have to cope with unpredictable environmental challenges such as fluctuations in nutritional resources. Insulin-like growth factor-1 (IGF-1) is an evolutionarily conserved hormone that is highly sensitive to the individual nutritional status and regulates major life-history traits including lifespan and reproduction across vertebrates. We investigated the role of IGF-1 during periods of food shortages by altering between two feeding regimes (110 and 70% of daily food intake) after a period of ad libitum feeding in captive bearded reedlings (Panurus biarmicus). Each dietary treatment was repeated twice. Birds lost mass under food restriction, but the magnitude of mass change depended on the preceding dietary conditions. Moreover, bearded reedlings showed large, repeatable individual differences in their IGF-1 reaction norms with some individuals increasing IGF-1 levels in response to a restricted diet, whereas others showed no responses or decreased IGF-1 levels. This variation was explained by differences in average body mass: heavier individuals had higher IGF-1 levels during the control treatment and were more likely to decrease IGF-1 levels in response to the dietary restriction than did lighter ones. This result uncovers an individual by environment interaction (I × E) and may have important implications for the evolution of IGF-1 related hormonal phenotypes in this species.

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