Juvenile Idiopathic Arthritis Associated Uveitis

Carlsson, Emil; Beresford, Michael W.; Ramanan, Athimalaipet V; Dick, Andrew D; Hedrich, Christian M.

doi:10.3390/children8080646

Cited by 18 publications

(11 citation statements)

References 104 publications

(137 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The seven subtypes of Juvenile idiopathic arthritis (JIA) can be divided into JIA with low risk of uveitis (systemic arthritis and other unclassified arthritis), moderate risk (polyarthritis rheumatoid factor, RF, positive) and higher risk of uveitis (oligoarthritis, persistent or extended; polyarthritis RF negative; enthesitis related arthritis or ERA, juvenile psoriatic arthritis or JpSA) ( 73 , 74 ). Chronic silent anterior uveitis is usually non-granulomatous in oligo or polyarticular JIA, as is acute anterior uveitis of ERA.…”

Section: Non-infectious Uveitismentioning

confidence: 99%

Pediatric uveitis: Role of the pediatrician

et al. 2022

View full text Add to dashboard Cite

The challenges of childhood uveitis lie in the varied spectrum of its clinical presentation, the often asymptomatic nature of disease, and the evolving nature of the phenotype alongside normal physiological development. These issues can lead to delayed diagnosis which can cause significant morbidity and severe visual impairment. The most common ocular complications include cataracts, band keratopathy, glaucoma, and macular oedema, and the various associated systemic disorders can also result in extra-ophthalmic morbidity. Pediatricians have an important role to play. Their awareness of the various presentations and etiologies of uveitis in children afford the opportunity of prompt diagnosis before complications arise. Juvenile Idiopathic Arthritis (JIA) is one of the most common associated disorders seen in childhood uveitis, but there is a need to recognize other causes. In this review, different causes of uveitis are explored, including infections, autoimmune and autoinflammatory disease. As treatment is often informed by etiology, pediatricians can ensure early ophthalmological referral for children with inflammatory disease at risk of uveitis and can support management decisions for children with uveitis and possible underling multi-system inflammatory disease, thus reducing the risk of the development of irreversible sequelae.

show abstract

Section: Non-infectious Uveitismentioning

confidence: 99%

Pediatric uveitis: Role of the pediatrician

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Children with JIA seldom have the chorioretinal disease (except macular edema), and therefore, have an unremarkable FA and ICGA. [ 28 ] Patients with OTB and sarcoidosis can have significant retinal vasculitis and optic nerve head inflammation with hyperfluorescence on FA (not reported in BS), active choroiditis (does not occur in BS), and choroidal granulomas which present with hypofluorescence on both FA and ICGA (not reported in BS). [ 28 29 30 ] Concilio et al .…”

Section: Ophthalmic Manifestations Of Bsmentioning

confidence: 99%

“…[ 28 ] Patients with OTB and sarcoidosis can have significant retinal vasculitis and optic nerve head inflammation with hyperfluorescence on FA (not reported in BS), active choroiditis (does not occur in BS), and choroidal granulomas which present with hypofluorescence on both FA and ICGA (not reported in BS). [ 28 29 30 ] Concilio et al . [ 31 ] have recently reported the relevance of anterior segment OCT (AS-OCT) in an 8-year-old girl with bilateral anterior granulomatous uveitis with underlying BS.…”

Section: Ophthalmic Manifestations Of Bsmentioning

confidence: 99%

Blau syndrome: An under-reported condition in India?

Agarwal

Karande

2022

Journal of Postgraduate Medicine

View full text Add to dashboard Cite

“…Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in the pediatric population and uveitis is its commonest extra-articular manifestation [ 2 , 3 ]. While this uveitis has been typically noted to be an asymptomatic chronic anterior uveitis until complications such as band-shaped keratopathy and cataract occur, there is limited literature of the posterior segment manifestations of the disease [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Reactivation of juvenile idiopathic arthritis associated uveitis with posterior segment manifestations following anti-SARS-CoV-2 vaccination

Mahendradas

Mishra

Mangla

et al. 2022

J Ophthal Inflamm Infect

View full text Add to dashboard Cite

Background/purpose Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in the pediatric population and anterior uveitis is its commonest extra-articular manifestation. Typically the uveitis presents as chronic anterior uveitis and there is limited literature of the posterior segment manifestations of the disease. Similar to other vaccines, anti-SARS-CoV-2 vaccination that began as an urgent measure to control the spread of the SARS-CoV-2 pandemic has not been without adverse events. We are reporting a 19-year-old Asian Indian female who was diagnosed and treated for JIA associated anterior uveitis that was unilateral and was under anti-inflammatory control but showed worsening of uveitis with posterior segment inflammation in both eyes following anti-SARS-CoV-2 vaccination. Case report A 19-year-old Asian Indian female with a history of juvenile idiopathic arthritis on treatment with methotrexate, presented with right eye chronic anterior uveitis with peripheral subclinical retinal vasculitis and macular edema which was brought under control following administration of adalimumab. She was inflammation free for 6 months until she received anti-SARS-CoV-2 vaccination and developed new onset floaters in both eyes that were initially noted after the first dose and increased after the second dose. Clinical examination revealed presence of keratic precipitates and grade 1+ anterior chamber inflammation along with vitiritis in both eyes. Fundus fluorescein angiography revealed angiographically active retinal vasculitis without the presence of macular edema in both eyes. This was managed with a short course of topical difluprednate and continuation of systemic immunosuppressive therapy with adalimumab and methotrexate. Conclusion JIA associated uveitis results from an autoimmune process which can be controlled with timely immunosuppressive treatment. It is important to be aware of the potential risk of flare up of uveitis with posterior segment manifestations following anti- SARS-CoV-2 vaccination.

show abstract

Juvenile Idiopathic Arthritis Associated Uveitis

Cited by 18 publications

References 104 publications

Pediatric uveitis: Role of the pediatrician

Pediatric uveitis: Role of the pediatrician

Blau syndrome: An under-reported condition in India?

Reactivation of juvenile idiopathic arthritis associated uveitis with posterior segment manifestations following anti-SARS-CoV-2 vaccination

Contact Info

Product

Resources

About