Juvenile idiopathic arthritis activity and function ability: deleterious effects in periodontal disease?

Pugliese, Camila; Vinne, Roberta T. A. van der; Campos, Lúcia M A; Guardieiro, Priscila R.; Saviolli, Cynthia; Bonfá, Eloísa; Pereira, Rosa Maria Rodrigues; Viana, Vilma Santos Trindade; Borba, Eduardo F.; Silva, Clóvis A.

doi:10.1007/s10067-015-3125-5

Cited by 19 publications

(29 citation statements)

References 41 publications

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“…However, we have not confirmed this association. Our own findings have shown the lack of differences in the occurrence of gingivitis between the JIA children and the control group, similar to other studies [13, 24, 46]. In the present study, a small gingival index seems to be a reflection of good oral hygiene.…”

Section: Discussionsupporting

confidence: 91%

Unstimulated salivary flow, pH, proteins and oral health in patients with Juvenile Idiopathic Arthritis

et al. 2017

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BackgroundThere have been inconsistent conclusions regarding salivary abnormalities and their effect on oral health of Juvenile Idiopathic Arthritis (JIA) patients. The purpose of the study was to evaluate the flow rate and selected biochemical parameters of unstimulated whole saliva in correlation to oral health in JIA children.MethodsThirty-four JIA patients and 34 age- and sex-matched controls not affected by JIA (C) were divided into two groups: with mixed and permanent dentition. DMFT/dmft, gingival and simplified oral hygiene indices were evaluated. Salivary flow rate, pH, lysozyme, lactoferrin, salivary protein concentrations and peroxidase activity were assessed.ResultsThe salivary flow rate was significantly lower in the total JIA group (0.41 ml/min) as compared with the C (0.51 ml/min) and in the permanent dentition of JIA children (0.43 ml/min) as compared with the C (0.61 ml/min). A significantly lower pH was observed in total (6.74), mixed (6.7) and permanent (6.76) dentition of JIA groups in comparison to the C (7.25, 7.21, 7.28 respectively). The specific activity of peroxidase was significantly higher in JIA patients (total 112.72 IU/l, mixed dentition 112.98 IU/l, permanent dentition 112.5 IU/l) than in the C group (total 70.03 IU/l, mixed dentition 71.83 IU/l, permanent dentition 68.61 IU/l). The lysozyme concentration in JIA patients (total and permanent dentition groups) was significantly higher than in the C group. There were no significant differences in lactoferrin and salivary protein concentrations. There were no statistically significant differences in oral status between JIA patients and C, respectively: DMFT = 5.71, dmft = 3.73, OHI-S = 0.95, GI = 0.25 and DMFT 5.71, dmft = 3.73, OHI-S = 0.85, GI = 0.24. The specific activity of peroxidase in the unstimulated whole saliva was inversely correlated with the GI index, whereas the salivary lysozyme concentration was inversely correlated with the dmft index in JIA patients.ConclusionIn the course of JIA occur a reduction of the resting salivary flow rate and a decrease of saliva pH. In spite of this, no differences in the clinical oral status between the JIA children population and the control group were found. The mobilisation of salivary peroxidase and lysozyme contributes to the maintenance of healthy oral tissues.

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Section: Discussionsupporting

confidence: 91%

Unstimulated salivary flow, pH, proteins and oral health in patients with Juvenile Idiopathic Arthritis

et al. 2017

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“…The great advantage of the study was to assess a concomitant evaluation of periodontal and lipid parameters in JDM patients and healthy controls. Tobacco use, alcohol intake, diabetes mellitus and some medications may be related to periodontal disorders and therefore they were considered as exclusion criteria [13]. Moreover, the control group included only JDM siblings or relatives, to minimize risk factors associated with periodontal diseases and dyslipidemia, particularly tooth brushing habits, nutrition and genetic factors.…”

Section: Discussionmentioning

confidence: 99%

“…Periodontitis is a progressive phenomenon, beginning with gingivitis, followed by the destruction of the periodontal ligaments and bone reabsorption and ending in dental attachment loss [4]. Gengivitis and/or periodontitis have been seldom studied in pediatric autoimmune diseases, like juvenile idiopathic arthritis and juvenile systemic lupus erythematosus [10][11][12][13][14][15] Recently the association between periodontal disease and dyslipidemia was reported in healthy adults [16].…”

Section: Introductionmentioning

confidence: 99%

Juvenile dermatomyositis: is periodontal disease associated with dyslipidemia?

et al. 2018

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Background: Association between periodontal disease and dyslipidemia was recently reported in healthy adults. However, a systematic evaluation of concomitant periodontal diseases and lipid profile was not carried out in juvenile dermatomyositis (JDM). A cross-section study was performed in 25 JDM patients and 25 healthy controls, assessing demographic data, periodontal evaluation, fasting lipoproteins and anti-lipoprotein lipase antibodies. Disease parameters, laboratorial tests and treatment were also evaluated in JDM patients. Results: The mean current age was similar in patients and controls (11.5 ± 3.75 vs. 11.2 ± 2.58 years,p = 0.703). Regarding lipid profile, the median triglycerides [80(31-340) vs. 61(19-182)mg/dL,p = 0.011] and vs. 13(4-36)mg/dL,p = 0.020] were significantly higher in JDM patients versus controls. Gingival vasculopathy pattern was significantly higher in the former group (60% vs. 0%,p = 0.0001), as well as the median of gingival bleeding index (GBI) [24.1(4.2-69.4) vs. 11.1(0-66.6)%,p = 0.001] and probing pocket depth (PPD) [1.7(0.6-2.4) vs.1.4(0-2.12) mm,p = 0.006]. Comparison between JDM patients with and without dyslipidemia revealed that the median of dental plaque index (PI) [100(26.7-100) vs. 59(25-100)%,p = 0.022], PPD[1.9(0.6-2.4) vs. 1.4(1.2-1.8)mm,p = 0.024] and clinical attachment level (CAL) [1.31(0.7-1.7) vs. 0.8(0.6-1.7)mm,p = 0.005] were significantly higher in patients with dyslipidemia. Further analysis between JDM patients with and without gingivitis revealed that the median of current age [12.4 (8.3-18.4) vs. 9.2 (5.5-17.5) years, p = 0.034] and disease duration [7.09 ± 3.07 vs. 3.95 ± 2.1 years, p = 0.008] were significantly higher in the former group.Conclusion: Our study showed that gingival inflammation seems to be related to dyslipidemia in JDM patients, suggesting underlying mechanisms for both complications.

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“…Previous studies about JIA patients showed inhomogeneous and controversial results regarding oral diseases [12,13,[16][17][18][19][20][21][22][23][24]. Some studies showed increased dental caries experience [24], gingival inflammation [16,18,19] and dental biofilm accumulation [12,17,19] whereas other studies could not confirm these results [12,13,[16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Assessment of Orofacial Health and Disease Related Parameters in Adolescents with Juvenile Idiopathic Arthritis—A Cross-Sectional Study

Merle

Hoffmann²,

Schmickler

et al. 2020

JCM

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Background: The aim of this cross-sectional study was to investigate oral health and functional status of adolescents with juvenile idiopathic arthritis (JIA) and its possible link to disease specific parameters. Methods: Patients with JIA were recruited (November 2012–October 2014) and disease specific information was extracted from patients’ records. Oral examination included: dental findings (decayed-, missing- and filled-teeth-index (dmf-t/DMF-T)), gingival inflammation (papilla-bleeding-index (PBI)) and periodontal screening index (PSI). Functional examination followed Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Additionally, modified Helkimo’s Clinical Dysfunction Index and radiographic scoring were recorded. Results: 59 JIA patients were included. The mean dmf-t/DMF-T was 2.6. Only one patient showed no signs of gingival inflammation, while 57.6% had a maximum PSI of 2 or less. Positive functional findings were assessed clinically in more than half of the patients. Major diagnosis by RDC/TMD was osteoarthrosis. Patients with at least one positive anamnestic or clinical functional finding revealed significantly higher radiographic scores (CI = 0.440, p = 0.022). Patients with increased c-reactive-protein had a significantly higher PBI (Z = –2.118, p = 0.034) and increased radiographic scores (CI = 0.408, p = 0.043). Conclusions: Adolescents suffering from JIA show high levels of caries experience and gingival inflammation. Temporomandibular joint dysfunction is often seen in JIA patients. Consequently, special dental care programs would be recommendable.

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Juvenile idiopathic arthritis activity and function ability: deleterious effects in periodontal disease?

Cited by 19 publications

References 41 publications

Unstimulated salivary flow, pH, proteins and oral health in patients with Juvenile Idiopathic Arthritis

Unstimulated salivary flow, pH, proteins and oral health in patients with Juvenile Idiopathic Arthritis

Juvenile dermatomyositis: is periodontal disease associated with dyslipidemia?

Comprehensive Assessment of Orofacial Health and Disease Related Parameters in Adolescents with Juvenile Idiopathic Arthritis—A Cross-Sectional Study

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