Juvenile gangrenous vasculitis of the scrotum: an exceptional cause of scrotal ulcers

Pinto-Almeida, Teresa; Rosmaninho, Aristóteles; Lobo, Inês; Alves, Rosário; Selores, Manuela

doi:10.1684/ejd.2012.1804

Cited by 7 publications

(29 citation statements)

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“…Specific drug reactions or contact history were not traceable. Histopathology of the ulcer was rather unspecific, including fibrinoid necrosis of small vessels, perivascular lymphocytic infiltrates, numerous extravasated red cells and abundant neutrophilic infiltrates in the deep dermis, consistent with vasculitis . Self‐limited course with complete resolution within 2–3 weeks but without relapse is the rule.…”

Section: Juvenile Gangrenous Vasculitis Of the Scrotummentioning

confidence: 95%

“…First presented in 1973, then published in 1974, juvenile gangrenous vasculitis of the scrotum is a rare form of acute painful scrotal ulcer of unclear aetiology observed in otherwise healthy young men. Less than 20 cases, including the original report of five cases, are known in the literature, very few in English . The majority of the patients was under 30 years old, the eldest 45 years old, with 1–5 round to polycyclic, sharply demarcated, initially with pruritic and burning sensation and rapidly progressive, painful necrotic ulcers with black eschars on the scrotum, 0.5–2 cm in diameter, the largest reported with 5 cm, preceded 1–3 weeks before by an episode of pharyngitis/tonsillitis with high fever (Fig.…”

Section: Juvenile Gangrenous Vasculitis Of the Scrotummentioning

confidence: 99%

“…Histopathology of the ulcer was rather unspecific, including fibrinoid necrosis of small vessels, perivascular lymphocytic infiltrates, numerous extravasated red cells and abundant neutrophilic infiltrates in the deep dermis, consistent with vasculitis. 33,34 Self-limited course with complete resolution within 2-3 weeks but without relapse is the rule. Therapeutic response to a short course of systemic antibiotics and steroids was reported to be effective in most cases, but a spontaneous healing of the ulcer is likely.…”

Section: Juvenile Gangrenous Vasculitis Of the Scrotummentioning

confidence: 99%

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Lipschütz genital ulcer revisited: is juvenile gangrenous vasculitis of the scrotum the male counterpart?

Chen

Plewig

2019

Acad Dermatol Venereol

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Since its first description as ulcus vulvae acutum by Benjamin Lipschütz in 1912, the etiopathogenesis of this peculiar genital ulcer remains incompletely understood. In his original description, two different types of genital ulcers were observed and proposed, which were not precisely defined and distinguished in most subsequent reports. The first type is characterized by acute excruciating genital ulcers of first‐time onset with self‐limited non‐recurrent course in association with gravely symptomatic systemic infections, in which a primary Epstein–Barr virus (EBV) infection is later identified to be probably the most common aetiology. The second type of ulcer usually refers to little painful ulcers of unknown etiopathogenesis in the absence of fever or chills and with a slow torpid progression and recurrent nature. Differentiation from idiopathic aphthous ulcers is unclear. The changes of the cervicovaginal microbiota and microbiome in diseased state deserve further clarification. Acute genital ulcers associated with primary EBV infection in women have drawn attention since 1970s, while the corresponding penile ulcers in men were already known in 1950s. First presented in 1973, juvenile gangrenous vasculitis of the scrotum with an acute painful scrotal ulcer preceded by symptomatic pharyngeal infections can be considered as the male counterpart of ulcus vulvae acutum, and the future clinical survey should include primary EBV infection.

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Section: Juvenile Gangrenous Vasculitis Of the Scrotummentioning

confidence: 95%

Section: Juvenile Gangrenous Vasculitis Of the Scrotummentioning

confidence: 99%

Section: Juvenile Gangrenous Vasculitis Of the Scrotummentioning

confidence: 99%

See 1 more Smart Citation

Lipschütz genital ulcer revisited: is juvenile gangrenous vasculitis of the scrotum the male counterpart?

Chen

Plewig

2019

Acad Dermatol Venereol

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“…Juvenile gangrenous vasculitis is a syndrome characterized by sudden onset of sharply defined cutaneous ulcerations, affecting exclusively young adults, usually a few days after upper respiratory infection symptoms. [1][2][3][4] The ulcer can be unique or in small numbers (usually < 5). Scrotal itching, stinging or burning may precede or accompany the skin lesions.…”

Section: Case Reportmentioning

confidence: 99%

“…Juvenile gangrenous vasculitis of the scrotum (JGV) is a particular form of scrotal gangrene of unknown origin that has been rarely reported since its first description in 1973 by Piñol et al 1 This entity affects adolescents and young adults (between 13 and 45 years old), [1][2][3][4] and it is characterized by an acute onset of skin ulcers in the scrotum after an upper respiratory infection. The ulcers heal with proper therapy or even spontaneously, with no relapses.…”

Section: Introductionmentioning

confidence: 99%

Juvenile gangrenous vasculitis of the scrotum: A rare cause of genital ulcer

et al. 2020

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Juvenile gangrenous vasculitis of the scrotum is a rare entity of unknown aetiology which should be considered in the differential diagnosis of genital ulcers, mainly with those caused by sexually transmitted infections. The authors report a case of a 23year-old patient who presented a single painful scrotal ulcer developing shortly after an episode of pharyngotonsillitis. The ulcer was treated with oral corticosteroids with total healing and no relapse in over two years of follow-up.

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