Juvenile chronic arthritis, chronic iridocyclitis, and reactivity to histones.

Leak, A M; Woo, Patricia

doi:10.1136/ard.50.9.653

Cited by 19 publications

(10 citation statements)

References 47 publications

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“…Twenty-eight of 30(93%) of patients with JIA with uveitis had antihistone antibodies while only 30(33%) of 91 patients without uveitis had anti-histone antibodies. This same study also suggests that anti-H3 speci c histone antibodies correlated with uveitis in the JIA population (8,9). More recent studies have also shown higher titer anti-histone antibodies as a risk factor development of uveitis in JIA (10).…”

supporting

confidence: 54%

Antibodies to Histone in the Pediatric Population: A Retrospective Chart Review

Moore

2021

Preprint

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Background:Antibodies to histone have been associated in the adult literature with systemic lupus erythematosus(SLE) and drug induced lupus(DILE). Little data is available regarding the spectrum of pathology that antibodies to histone encompass in the pediatric population. Prior studies suggest an association with SLE, juvenile idiopathic arthritis(JIA), uveitis and linear scleroderma.Methods:Patient charts were reviewed that contained positive anti-histone antibody testing during a consecutive three year period. Patient diagnosis along with the presence of: anti-histone antibody titer, ANA, and the presence of other autoantibodies to SSA, SSB, Sm, RNP, dsDNA and chromatin were obtained. The frequency of SLE, JIA and DILE was further investigated in specific subsets.Results:139 individual charts were reviewed containing 41 different diagnoses. The most common diagnosis was hypermobility arthralgia with 22 patients. The most frequent rheumatologic diagnosis was JIA(non-systemic) with 19. 13 patients in this study were diagnosed with SLE and 2 with DILE. 18 patients had other autoantibody production, of these, 11 had SLE or DILE. Only one of 62 patients with a weak anti-histone antibody titer(1.0-1.5) was diagnosed with SLE. When strong titers are present(>2.5), the anti-histone antibody test was associated with a greater than 50% incidence of an underlying rheumatologic disease and ten times higher incidence of SLE than a weak titer. In regards to the frequency of SLE, there was a statistically significant difference in weak and moderate(1.6-2.5) titers(p-value 0.0113) and weak and strong titers(p-value 0.0053). Conclusion:The presence of anti-histone antibody was observed in a variety of diagnoses in the pediatric population. Overall, the presence of anti-histone antibodies appears to have poor diagnostic utility for any specific condition. However, diagnostic utility for SLE does improve with higher titers, when combined with other autoantibody positivity. Strength of titer did not appear to be a factor for JIA, but was the most frequently observed rheumatologic disease in this study.

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confidence: 54%

Antibodies to Histone in the Pediatric Population: A Retrospective Chart Review

Moore

2021

Preprint

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“…in patients with systemic lupus erythematosus, [16][17][18][19] and is involved in other autoimmune diseases such as multiple sclerosis, diabetes and rheumatoid arthritis. 2, 20,21 Further functions of histones are the stabilization of sea urchin flagellar microtubules, 18 and protection against infection of mice with Leishmania major by histone H1. 3 The binding of lipopolysaccharide, the stimulation of tumour necrosis factor-a (TNF-a), interleukin-6 (IL-6) expression and other inflammatory mediators, [22][23][24][25] confirm the hypothesis that histone has a central role in immune modulation.…”

Section: Introductionmentioning

confidence: 99%

Activity of histone H1.2 in infected burn wounds

Jacobsen

Baraniskin²,

Mertens³

et al. 2005

Journal of Antimicrobial Chemotherapy

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“…Several previous studies have reported association of JRA with different human leukocyte antigen (HLA) class I and class II alleles, which underlines the clinical and immunological heterogeneity of the disease (Leak & Woo, 1991; Southwood & Malleson, 1991; Fernandez‐Vina et al. , 1994; Glass & Giannini, 1999; McCurdy, 1999).…”

Section: Introductionmentioning

confidence: 95%

Prevalence of human leukocyte antigen (HLA) DRB1 alleles in Kuwaiti children with juvenile rheumatoid arthritis

Alsaeid

Haider

Kamal

et al. 2002

European Journal of Immunogenetics

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The prevalence of human leukocyte antigen (HLA) DR alleles has been determined in 69 Kuwaiti Arab children with juvenile rheumatoid arthritis (JRA) and compared to that in 212 ethnically matched normal healthy controls using a PCR-sequence specific primers (PCR-SSP) method. A very high incidence of DR3 was detected in JRA patients compared to the controls (P < 0.0001, RR = 2.235). The high incidence of HLA-DR3 in JRA patients was accounted for mainly by an excess of DRB1*0307 (P < 0.05, RR = 3.072) and DRB1*0308 (P < 0.009, RR = 2.663) compared to the controls. Moreover, DR3 was more prevalent when patients with ANA-positive JRA were analysed separately; 73% compared to 58% for the whole JRA patient group. The frequency of DR1 was also higher in the JRA group compared to controls (P = 0.019, RR = 3.585). Although the incidence of some alleles was higher in the control group (DR13 and DR7), none reached a statistically significant level. All the patients with iridocyclitis had either a DR1 or DR3 allele, except for one child. The frequency of DRB1*03 was found to be much higher in the polyarticular subtype of Kuwaiti JRA cases compared to the oligoarticular subgroup and the controls. Also, a non-significant increase in the frequency of the DRB1*04, *11 and *15 alleles was detected in the polyarticular subtype of the Kuwaiti JRA cases compared to the controls.

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Juvenile chronic arthritis, chronic iridocyclitis, and reactivity to histones.

Cited by 19 publications

References 47 publications

Antibodies to Histone in the Pediatric Population: A Retrospective Chart Review

Antibodies to Histone in the Pediatric Population: A Retrospective Chart Review

Activity of histone H1.2 in infected burn wounds

Prevalence of human leukocyte antigen (HLA) DRB1 alleles in Kuwaiti children with juvenile rheumatoid arthritis

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