Justification for exogenous replacement of magnesium deficiency in women planning pregnancy: experienc of using the drug

Abstract

Introduction. During pregnancy, the body’s need for most micronutrients increases, and therefore timely detection and adequate correction of deficient conditions are justified, starting from the stage of pre-gravidar preparation.Objective. The purpose of the study is to present literature data on the role of magnesium in homeostasis and own experience of the effectiveness of the use of magnesium preparation.Materials and methods. A review of the literature for 2021–2023 in the databases was conducted in the databases PubMed (the National Library of Medicine), The Cochrane Library, as well as in scientific citation databases (Scopus, Web of Science) The experience of own application of the preparation containing magnesium lactate dihydrate (470 mg) is also presented + pyridoxine hydrochloride (5 mg).Result and discussion. The intake of magnesium into the human body with food is insufficient. Exogenous magnesium replenishment is clinically justified in isolated or associated with other conditions of established deficiency, primarily with intense emotional and physical exertion, sleep deprivation, as well as with emotional lability, palpitations, muscle fasciculations, with magnesium elimination due to iatrogenic exposure or increased demand, for example, gestational-conditioned. Regular use of Magne B6® has demonstrated its effectiveness in the treatment of symptoms of psychological daily stress (fatigue, irritability, deterioration of sleep quality) in women planning pregnancy.Conclusions. The results obtained appear to be important in terms of reducing the risks of clinical progression of somatic symptoms and potential gestational complications, as well as improving the quality of life of childbearing age women who are actively planning to implement their reproductive function.