Just When We Thought We Knew Everything We Needed To Know about Zn Acquisition and Bacterial Pathogenesis

Roop, R. Martin

doi:10.1128/jb.00694-17

Cited by 1 publication

(1 citation statement)

References 19 publications

(22 reference statements)

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“…Interestingly, the mechanism of zinc acquisition is different between environmental and virulent species in Francisella . ZupT is the primary zinc acquisition transporter in environmental Francisella , however, it is not zupT but ZnuA that plays a crucial role in zinc uptake in virulent Francisella [ 34 ]. These data highlight the large and intricate arsenal of zinc import systems used by bacteria.…”

Section: Discussionmentioning

confidence: 99%

Zinc uptake system ZnuACB is essential for maintaining pathogenic phenotype of F4ac+ enterotoxigenic E. coli (ETEC) under a zinc restricted environment

Quan

Xia

Lian

et al. 2020

Vet Res

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Zinc is the second trace element of living organisms after iron. Given its crucial importance, mammalian hosts restrict the bioavailability of Zinc ions (Zn2+) to bacterial pathogens. As a countermeasure, pathogens utilize high affinity Zn2+ transporters, such as ZnuACB to compete with the host for zinc. It is essential for bacteria to maintain zinc homeostasis and thus maintain their physiology and pathogenesis. In an attempt to uncover the zinc transporter in F4+ enterotoxigenic E. coli (ETEC) C83902, we analyzed two RNA-seq data sets of bacteria samples when different zinc treatments (restriction or abundance) were applied. Considering data revealing that the high affinity zinc uptake system ZnuACB acts as the main transporter in ETEC C83902 to resist zinc deficiency, we deleted znuACB genes to study the role of them in ETEC C83902. The deletion of znuACB genes results in growth perturbation and a sharp decrease in the ability of biofilm formation and adhesion of bacteria in vitro. Taking the data together, this study demonstrates that the ZnuACB system is required for ETEC C83902 to acquire zinc, which highly contributes to ETEC pathogenicity as well.

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Section: Discussionmentioning

confidence: 99%

Zinc uptake system ZnuACB is essential for maintaining pathogenic phenotype of F4ac+ enterotoxigenic E. coli (ETEC) under a zinc restricted environment

Quan

Xia

Lian

et al. 2020

Vet Res

View full text Add to dashboard Cite

show abstract

Just When We Thought We Knew Everything We Needed To Know about Zn Acquisition and Bacterial Pathogenesis

Abstract: It is well established that high-affinity zinc importers play essential roles in bacterial virulence, but the studies described by Moreau et al. in

Cited by 1 publication

References 19 publications

Zinc uptake system ZnuACB is essential for maintaining pathogenic phenotype of F4ac+ enterotoxigenic E. coli (ETEC) under a zinc restricted environment

Zinc uptake system ZnuACB is essential for maintaining pathogenic phenotype of F4ac+ enterotoxigenic E. coli (ETEC) under a zinc restricted environment

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